Browsing by Author "Lembo, Anthony"
Now showing items 1-11 of 11
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A 12-Week, Randomized, Controlled Trial with a 4-Week Randomized Withdrawal Period to Evaluate the Efficacy and Safety of Linaclotide in Irritable Bowel Syndrome with Constipation
Rao, Satish; Shiff, Steven J; Lavins, Bernard J; Jia, Xinwei D; Shi, Kelvin; MacDougall, James E; Shao, James Z; Eng, Paul; Fox, Susan M; Schneier, Harvey A; Kurtz, Caroline B; Johnston, Jeffrey M; Lembo, Anthony J.; Currie, Mark G. (Nature Publishing Group, 2012)Objectives: Linaclotide is a minimally absorbed guanylate cyclase-C agonist. The objective of this trial was to determine the efficacy and safety of linaclotide in patients with irritable bowel syndrome with constipation ... -
Adequate Relief in a Treatment Trial With IBS Patients: A Prospective Assessment
Passos, Maria C F; Lembo, Anthony J.; Conboy, Lisa Ann; Kaptchuk, Ted Jack; Kelly, John M; Quilty, Mary T; Kerr, Catherine; Jacobson, Eric Emil; Hu, Rong; Friedlander, Elizabeth; Drossman, Douglas A (Nature Publishing Group, 2009)Background: Adequate relief of IBS symptoms (IBS-AR) has been used as a primary endpoint in many randomized controlled trials of IBS and is considered by the Rome III Committee to be an acceptable primary endpoint. However, ... -
Catechol-O-Methyltransferase val158met Polymorphism Predicts Placebo Effect in Irritable Bowel Syndrome
Hall, Kathryn Tayo; Lembo, Anthony J.; Kirsch, Irving; Ziogas, Dimitrios C.; Douaiher, Jeffrey; Jensen, Karin; Conboy, Lisa Ann; Kelley, John Michael; Kokkotou, Efi G.; Kaptchuk, Ted Jack (Public Library of Science, 2012)Identifying patients who are potential placebo responders has major implications for clinical practice and trial design. Catechol-O-methyltransferase (COMT), an important enzyme in dopamine catabolism plays a key role in ... -
Conscientiousness is modified by genetic variation in catechol-O-methyltransferase to reduce symptom complaints in IBS patients
Hall, Kathryn T; Tolkin, Benjamin R; Chinn, Garrett M; Kirsch, Irving; Kelley, John M; Lembo, Anthony J; Kaptchuk, Ted J; Kokkotou, Efi; Davis, Roger B; Conboy, Lisa A (BlackWell Publishing Ltd, 2014)Background: Attention to and perception of physical sensations and somatic states can significantly influence reporting of complaints and symptoms in the context of clinical care and randomized trials. Although anxiety and ... -
“Maybe I Made Up the Whole Thing”: Placebos and Patients’ Experiences in a Randomized Controlled Trial
Kaptchuk, Ted Jack; Shaw, Jessica; Kerr, Catherine; Conboy, Lisa Ann; Kelley, John Michael; Csordas, Thomas J.; Lembo, Anthony J.; Jacobson, Eric Emil (Springer Verlag, 2009)Patients in the placebo arms of randomized controlled trials (RCT) often experience positive changes from baseline. While multiple theories concerning such “placebo effects” exist, peculiarly, none has been informed by ... -
Patient and Practitioner Influences on the Placebo Effect in Irritable Bowel Syndrome
Kelley, John Michael; Lembo, Anthony J.; Ablon, John Stuart; Villanueva, Joel J.; Conboy, Lisa Ann; Levy, Raymond Arthur; Marci, Carl David; Kerr, Catherine; Kirsch, Irving; Jacobson, Eric Emil; Riess, Helen; Kaptchuk, Ted Jack (Ovid Technologies (Wolters Kluwer Health), 2009)Objective: To determine whether placebo responses can be explained by characteristics of the patient, the practitioner, or their interpersonal interaction. Methods: We performed an analysis of videotape and psychometric ... -
Patient-Provider Interactions Affect Symptoms in Gastroesophageal Reflux Disease: A Pilot Randomized, Double-Blind, Placebo-Controlled Trial
Dossett, Michelle L.; Mu, Lin; Davis, Roger B.; Bell, Iris R.; Lembo, Anthony J.; Kaptchuk, Ted J.; Yeh, Gloria Y. (Public Library of Science, 2015)Background: It is unclear whether the benefits that some patients derive from complementary and integrative medicine (CIM) are related to the therapies recommended or to the consultation process as some CIM provider visits ... -
Placebos without Deception: A Randomized Controlled Trial in Irritable Bowel Syndrome
Kaptchuk, Ted Jack; Friedlander, Elizabeth; Kelley, John Michael; Sanchez, M. Norma; Kokkotou, Efi G.; Singer, Joyce P.; Kowalczykowski, Magda; Miller, Franklin G.; Kirsch, Irving; Lembo, Anthony J. (Public Library of Science, 2010)Background: Placebo treatment can significantly influence subjective symptoms. However, it is widely believed that response to placebo requires concealment or deception. We tested whether open-label placebo (non-deceptive ... -
Randomised clinical trial: alosetron improves quality of life and reduces restriction of daily activities in women with severe diarrhoea-predominant IBS
Cremonini, F; Nicandro, J P; Atkinson, V; Shringarpure, R; Chuang, E; Lembo, Anthony J. (Blackwell Publishing Ltd, 2012)Background: Patients with irritable bowel syndrome with diarrhoea (IBS-D) experience restriction in daily activities and decreased health-related quality of life (QOL). Aim To investigate effects of alosetron on ... -
A Treatment Trial of Acupuncture in IBS Patients
Lembo, Anthony J.; Conboy, Lisa Ann; Kelley, John Michael; Schnyer, Rosa S; McManus, Claire A; Quilty, Mary T; Kerr, Catherine; Drossman, Doug; Jacobson, Eric Emil; Davis, Roger B.; Kaptchuk, Ted Jack (Nature Publishing Group, 2009)Objective: To compare the effects of true and sham acupuncture in relieving symptoms of IBS. Methods: A total of 230 adult IBS patients (75% females, average age 38.4 yrs) were randomly assigned to 3 weeks of true or sham ... -
The Zelnorm Epidemiologic Study (ZEST): A Cohort Study Evaluating Incidence of Abdominal and Pelvic Surgery Related to Tegaserod Treatment
Seeger, John; Quinn, Sherry; Earnest, David L; Lembo, Anthony J.; Kuo, Braden; Rivero, Elena; Walker, Alexander M. (BioMed Central, 2012)Background: Pre-marketing clinical studies of tegaserod suggested an increased risk of abdominal surgery, particularly cholecystectomy. We sought to quantify the association between tegaserod use and the occurrence of ...