Now showing items 1-20 of 25

    • Arithmetic and local circuitry underlying dopamine prediction errors 

      Eshel, Neir (2014-10-21)
      Predictions help guide learning. As we encounter objects in our environment, we make predictions about their value. When outcomes match our predictions, learning is not required. When outcomes are unexpected, however, we ...
    • Bilingual neurons release glutamate and GABA 

      Uchida, Naoshige (Nature Publishing Group, 2014)
      A study finds evidence supporting co-release of glutamate and GABA, excitatory and inhibitory fast neurotransmitters, from a single axon terminal in neurons of the ventral tegmental area that project to the lateral habenula.
    • Coding and Transformations in the Olfactory System 

      Uchida, Naoshige; Poo, Cindy; Haddad, Rafi (Annual Reviews, 2014)
      How is sensory information represented in the brain? A long-standing debate in neural coding is whether and how timing of spikes conveys information to downstream neurons. Although we know that neurons in the olfactory ...
    • A defined network of fast-spiking interneurons in orbitofrontal cortex: responses to behavioral contingencies and ketamine administration 

      Quirk, Michael C.; Sosulski, Dara L.; Feierstein, Claudia E.; Uchida, Naoshige; Mainen, Zachary F. (Frontiers Media SA, 2009)
      Orbitofrontal cortex (OFC) is a region of prefrontal cortex implicated in the motivational control of behavior and in related abnormalities seen in psychosis and depression. It has been hypothesized that a critical mechanism ...
    • Dopamine neurons projecting to the posterior striatum form an anatomically distinct subclass 

      Menegas, William; Bergan, Joseph F; Ogawa, Sachie K; Isogai, Yoh; Umadevi Venkataraju, Kannan; Osten, Pavel; Uchida, Naoshige; Watabe-Uchida, Mitsuko (eLife Sciences Publications, Ltd, 2015)
      Combining rabies-virus tracing, optical clearing (CLARITY), and whole-brain light-sheet imaging, we mapped the monosynaptic inputs to midbrain dopamine neurons projecting to different targets (different parts of the striatum, ...
    • Dopamine neurons projecting to the posterior striatum form an anatomically distinct subclass 

      Menegas, William; Bergan, Joseph F; Ogawa, Sachie K; Isogai, Yoh; Umadevi Venkataraju, Kannan; Osten, Pavel; Uchida, Naoshige; Watabe-Uchida, Mitsuko (eLife Sciences Publications, Ltd, 2015)
      Combining rabies-virus tracing, optical clearing (CLARITY), and whole-brain light-sheet imaging, we mapped the monosynaptic inputs to midbrain dopamine neurons projecting to different targets (different parts of the striatum, ...
    • Dopamine neurons share common response function for reward prediction error 

      Eshel, Neir; Tian, Ju; Bukwich, Michael Anthony; Uchida, Naoshige (Springer Nature, 2016)
      Dopamine neurons are thought to signal reward prediction error, or the difference between actual and predicted reward. How dopamine neurons jointly encode this information, however, remains unclear. One possibility is that ...
    • The dorsomedial striatum encodes net expected return, critical for energizing performance vigor 

      Wang, Alice Y.; Miura, Keiji; Uchida, Naoshige (2013)
      Decision making requires an actor to not only steer behavior towards specific goals, but also determine the optimal vigor of performance. Current research and models have largely focused on the former problem of how actions ...
    • Illuminating Vertebrate Olfactory Processing 

      Spors, Hartwig; Albeanu, Dinu Florin; Murthy, Venkatesh N.; Rinberg, Dmitry; Uchida, Naoshige; Wachowiak, Matt; Friedrich, Rainer W. (Society for Neuroscience, 2012)
      The olfactory system encodes information about molecules by spatiotemporal patterns of activity across distributed populations of neurons and extracts information from these patterns to control specific behaviors. Recent ...
    • Midbrain dopamine neurons signal aversion in a reward-context-dependent manner 

      Matsumoto, Hideyuki; Tian, Ju; Uchida, Naoshige; Watabe-Uchida, Mitsuko (eLife Sciences Publications, Ltd, 2016)
      Dopamine is thought to regulate learning from appetitive and aversive events. Here we examined how optogenetically-identified dopamine neurons in the lateral ventral tegmental area of mice respond to aversive events in ...
    • Motion Processing in the Larval Zebrafish Tectum 

      Grama, Abhinav Satish (2015-05-14)
      Larval zebrafish are highly visual animals that display a diverse repertoire of visually guided behaviors. Five days after their birth, they start tracking and hunting moving prey, a behavior that likely requires underlying ...
    • Neural Correlates, Computation and Behavioural Impact of Decision Confidence 

      Kepecs, Adam; Uchida, Naoshige; Zariwala, Hatim A.; Mainen, Zachary F. (Nature Publishing Group, 2008)
      Humans and other animals must often make decisions on the basis of imperfect evidence. Statisticians use measures such as P values to assign degrees of confidence to propositions, but little is known about how the brain ...
    • Neural Substrates of Choosing Actions and Motivational Drive, a Role for the Striatum 

      Wang, Alice (2012-11-01)
      Optimal decision making requires one to determine the best action among available alternatives as well as the most appropriate level of engagement for performance. While current research and models of decision making have ...
    • Neuron-Type-Specific Signals for Reward and Punishment in the Ventral Tegmental Area 

      Cohen, Jeremiah Yaacov; Haesler, Sebastian; Vong, Linh; Lowell, Bradford Barr; Uchida, Naoshige (Nature Publishing Group, 2012)
      Dopamine has a central role in motivation and reward. Dopaminergic neurons in the ventral tegmental area (VTA) signal the discrepancy between expected and actual rewards (that is, reward prediction error)1–3, but how they ...
    • A Novel Excitatory Paraventricular Nucleus to AgRP Neuron Circuit that Drives Hunger 

      Krashes, Michael J.; Shah, Bhavik P.; Madara, Joseph C.; Olson, David P.; Strochlic, David E.; Garfield, Alastair S.; Vong, Linh; Pei, Hongjuan; Watabe-Uchida, Mitsuko; Uchida, Naoshige; Liberles, Stephen D.; Lowel, Bradford B. (2014)
      Summary Hunger is a hard-wired motivational state essential for survival. Agouti-related peptide (AgRP)-expressing neurons in the arcuate nucleus (ARC) at the base of the hypothalamus are crucial to its control. They are ...
    • Odor concentration invariance by chemical ratio coding 

      Uchida, Naoshige; Mainen, Zachary F. (Frontiers Media S.A., 2008)
      Many animal species rely on chemical signals to extract ecologically important information from the environment. Yet in natural conditions chemical signals will frequently undergo concentration changes that produce differences ...
    • Odor Representations in Olfactory Cortex: Distributed Rate Coding and Decorrelated Population Activity 

      Miura, Keiji; Mainen, Zachary F.; Uchida, Naoshige (Elsevier BV, 2012)
      How information encoded in neuronal spike trains is used to guide sensory decisions is a fundamental question. In olfaction, a single sniff is sufficient for fine odor discrimination but the neural representations on which ...
    • Olfactory cortical neurons read out a relative time code in the olfactory bulb 

      Haddad, Rafi; Lanjuin, Anne; Madisen, Linda; Zeng, Hongkui; Murthy, Venkatesh N.; Uchida, Naoshige (2013)
      Odor stimulation evokes complex spatiotemporal activity in the olfactory bulb, suggesting that the identity of activated neurons as well as the timing of their activity convey information about odors. However, whether and ...
    • Opposite initialization to novel cues in dopamine signaling in ventral and posterior striatum in mice 

      Menegas, William; Babayan, Benedicte M; Uchida, Naoshige; Watabe-Uchida, Mitsuko (eLife Sciences Publications, Ltd, 2017)
      Dopamine neurons are thought to encode novelty in addition to reward prediction error (the discrepancy between actual and predicted values). In this study, we compared dopamine activity across the striatum using fiber ...
    • Organization of Monosynaptic Inputs to the Serotonin and Dopamine Neuromodulatory Systems 

      Ogawa, Sachie K.; Cohen, Jeremiah Y.; Hwang, Dabin; Uchida, Naoshige; Watabe-Uchida, Mitsuko (Elsevier BV, 2014)
      Serotonin and dopamine are major neuromodulators. Here, we used a modified rabies virus to identify monosynaptic inputs to serotonin neurons in the dorsal and median raphe (DR and MR). We found that inputs to DR and MR ...