Now showing items 1-5 of 5

    • Blocking the formation of radiation–induced breast cancer stem cells 

      Wang, Yangyang; Li, Wende; Patel, Shalin S.; Cong, Juan; Zhang, Nan; Sabbatino, Francesco; Liu, Xiaoyan; Qi, Yuan; Huang, Peigen; Lee, Hang; Taghian, Alphonse; Li, Jian-Jian; DeLeo, Albert B.; Ferrone, Soldano; Epperly, Michael W.; Ferrone, Cristina R.; Ly, Amy; Brachtel, Elena F.; Wang, Xinhui (Impact Journals LLC, 2014)
      The goal of adjuvant (post-surgery) radiation therapy (RT) for breast cancer (BC) is to eliminate residual cancer cells, leading to better local tumor control and thus improving patient survival. However, radioresistance ...
    • Computational Pathology to Discriminate Benign from Malignant Intraductal Proliferations of the Breast 

      Dong, Fei; Irshad, Humayun; Oh, Eun-Yeong; Lerwill, Melinda F.; Brachtel, Elena F.; Jones, Nicholas C.; Knoblauch, Nicholas W.; Montaser-Kouhsari, Laleh; Johnson, Nicole B.; Rao, Luigi K. F.; Faulkner-Jones, Beverly; Wilbur, David C.; Schnitt, Stuart J.; Beck, Andrew H. (Public Library of Science, 2014)
      The categorization of intraductal proliferative lesions of the breast based on routine light microscopic examination of histopathologic sections is in many cases challenging, even for experienced pathologists. The development ...
    • Mitotic Figure Recognition: Agreement among Pathologists and Computerized Detector 

      Malon, Christopher; Brachtel, Elena; Cosatto, Eric; Graf, Hans Peter; Kurata, Atsushi; Kuroda, Masahiko; Meyer, John S.; Saito, Akira; Wu, Shulin; Yagi, Yukako (IOS Press, 2012)
      Despite the prognostic importance of mitotic count as one of the components of the Bloom – Richardson grade [3], several studies ([2, 9, 10]) have found that pathologists’ agreement on the mitotic grade is fairly modest. ...
    • Origins of lymphatic and distant metastases in human colorectal cancer 

      Naxerova, Kamila; Reiter, Johannes; Brachtel, Elena F.; Lennerz, Jochen Klaus Maria; van de Wetering, Marc; Rowan, Andrew; Cai, Tianxi; Clevers, Hans; Swanton, Charles; Nowak, Martin A.; Elledge, Stephen J.; Jain, Rakesh K. (American Association for the Advancement of Science (AAAS), 2017)
      The spread of cancer cells from primary tumors to regional lymph nodes is often associated with reduced survival. One prevailing model to explain this association posits that fatal, distant metastases are seeded by lymph ...
    • Prediction of primary breast cancer size and T-stage using micro-computed tomography in lumpectomy specimens 

      Sarraj, WafaM; Tang, Rong; Najjar, Anas L; Griffin, Molly; Bui, Anthony H; Zambeli-Ljepovic, Alan; Senter-Zapata, Mike; Lewin-Berlin, Maya; Fernandez, Leopoldo; Buckley, Juliette; Ly, Amy; Brachtel, Elena F.; Aftreth, Owen; Gilbertson, John R; Yagi, Yukako; Gadd, Michele Annette; Hughes, Kevin S.; Smith, BarbaraL; Michaelson, JamesS (Medknow, 2015)
      Background: Histopathology is the only accepted method to measure and stage the breast tumor size. However, there is a need to find another method to measure and stage the tumor size when the pathological assessment is not ...