Browsing by Author "Glicksman, Marcie A."
Now showing items 1-6 of 6
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Characterization of Novel Src Family Kinase Inhibitors to Attenuate Microgliosis
Manocha, Gunjan D.; Puig, Kendra L.; Austin, Susan A.; Seyb, Kathleen; Glicksman, Marcie A.; Combs, Colin K. (Public Library of Science, 2015)Microgliosis is a major hallmark of Alzheimer’s disease (AD) brain pathology. Aβ peptide is hypothesized to act as a stimulus for microglia leading to activation of non-receptor tyrosine kinases and subsequent secretion ... -
Development of a Fluorescent Quenching Based High Throughput Assay to Screen for Calcineurin Inhibitors
Mukherjee, Abhisek; Syeb, Kathleen; Concannon, John; Callegari, Keri; Soto, Claudio; Glicksman, Marcie A. (Public Library of Science, 2015)Currently there is no effective treatment available for major neurodegenerative disorders associated to protein misfolding, including Alzheimer’s and Parkinson's disease. One of most promising therapeutic approaches under ... -
Enhancement of SMN protein levels in a mouse model of spinal muscular atrophy using novel drug-like compounds
Cherry, Jonathan J; Osman, Erkan Y; Evans, Matthew C; Choi, Sungwoon; Xing, Xuechao; Cuny, Gregory D; Glicksman, Marcie A; Lorson, Christian L; Androphy, Elliot J (Blackwell Publishing Ltd, 2013)Spinal muscular atrophy (SMA) is a neurodegenerative disease that causes progressive muscle weakness, which primarily targets proximal muscles. About 95% of SMA cases are caused by the loss of both copies of the SMN1 gene. ... -
A New Means To Identify Type 3 Secreted Effectors: Functionally Interchangeable Class IB Chaperones Recognize a Conserved Sequence
Costa, Sonia; Schmitz, Alexa M.; Jahufar, Fathima F.; Boyd, Justin D.; Cho, Min Y.; Glicksman, Marcie Ann; Lesser, Cammie (American Society of Microbiology, 2012)Many Gram-negative bacteria utilize specialized secretion systems to inject proteins (effectors) directly into host cells. Little is known regarding how bacteria ensure that only small subsets of the thousands of proteins ... -
Restored glial glutamate transporter EAAT2 function as a potential therapeutic approach for Alzheimer’s disease
Takahashi, Kou; Kong, Qiongman; Lin, Yuchen; Stouffer, Nathan; Schulte, Delanie A.; Lai, Liching; Liu, Qibing; Chang, Ling-Chu; Dominguez, Sky; Xing, Xuechao; Cuny, Gregory D.; Hodgetts, Kevin J.; Glicksman, Marcie A.; Lin, Chien-Liang Glenn (The Rockefeller University Press, 2015)Glutamatergic systems play a critical role in cognitive functions and are known to be defective in Alzheimer’s disease (AD) patients. Previous literature has indicated that glial glutamate transporter EAAT2 plays an essential ... -
Tetrandrine identified in a small molecule screen to activate mesenchymal stem cells for enhanced immunomodulation
Yang, Zijiang; Concannon, John; Ng, Kelvin S.; Seyb, Kathleen; Mortensen, Luke J.; Ranganath, Sudhir; Gu, Fangqi; Levy, Oren; Tong, Zhixiang; Martyn, Keir; Zhao, Weian; Lin, Charles P.; Glicksman, Marcie A.; Karp, Jeffrey M. (Nature Publishing Group, 2016)Pre-treatment or priming of mesenchymal stem cells (MSC) prior to transplantation can significantly augment the immunosuppressive effect of MSC-based therapies. In this study, we screened a library of 1402 FDA-approved ...