Browsing by Author "Medvetz, Douglas A"
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Folliculin regulates cell–cell adhesion, AMPK, and mTORC1 in a cell‐type‐specific manner in lung‐derived cells
Khabibullin, Damir; Medvetz, Douglas A.; Pinilla, Miguel; Hariharan, Venkatesh; Li, Chenggang; Hergrueter, Anja; Laucho Contreras, Maria; Zhang, Erik; Parkhitko, Andrey; Yu, Jane J.; Owen, Caroline A.; Huang, Hayden; Baron, Rebecca M.; Henske, Elizabeth P. (Wiley Periodicals, Inc., 2014)Abstract Germline loss‐of‐function BHD mutations cause cystic lung disease and hereditary pneumothorax, yet little is known about the impact of BHD mutations in the lung. Folliculin (FLCN), the product of the Birt–Hogg–Dube ... -
Folliculin, the Product of the Birt-Hogg-Dube Tumor Suppressor Gene, Interacts with the Adherens Junction Protein p0071 to Regulate Cell-Cell Adhesion
Medvetz, Douglas A; Khabibullin, Damir; Hariharan, Venkatesh; Ongusaha, Pat P.; Goncharova, Elena A.; Schlechter, Tanja; Darling, Thomas N.; Hofmann, Ilse; Krymskaya, Vera P.; Liao, James K.; Huang, Hayden; Henske, Elizabeth Petri (Public Library of Science, 2012)Birt-Hogg-Dube (BHD) is a tumor suppressor gene syndrome associated with fibrofolliculomas, cystic lung disease, and chromophobe renal cell carcinoma. In seeking to elucidate the pathogenesis of BHD, we discovered a physical ... -
MicroRNA-21 is Induced by Rapamycin in a Model of Tuberous Sclerosis (TSC) and Lymphangioleiomyomatosis (LAM)
Trindade, Anil Julius; Medvetz, Douglas A; Neuman, Nicole A.; Myachina, Faina; Yu, Jane J; Priolo, Carmen; Henske, Elizabeth Petri (Public Library of Science, 2013)Lymphangioleiomyomatosis (LAM), a multisystem disease of women, is manifest by the proliferation of smooth muscle-like cells in the lung resulting in cystic lung destruction. Women with LAM can also develop renal ...