Now showing items 1-20 of 30

    • Bet-hedging, seasons and the evolution of behavioral diversity in Drosophila 

      Kain, Jamey; Zhang, Sarah; Klein, Mason Joseph; Samuel, Aravinthan DT; de Bivort, Benjamin Lovegren (2015)
      Organisms use various strategies to cope with fluctuating environmental conditions. In diversified bet-hedging, a single genotype exhibits phenotypic heterogeneity with the expectation that some individuals will survive ...
    • Bidirectional thermotaxis in Caenorhabditis elegans is mediated by distinct sensorimotor strategies driven by the AFD thermosensory neurons 

      Luo, Linjiao; Cook, N.; Venkatachalam, Vivek; Martinez-Velazquez, L. A.; Zhang, Xiaosong; Calvo, A. C.; Hawk, J.; Macinnis, Bronwyn Lee; Frank, Michelle Murrah; Ng, J. H. R.; Klein, Mason Joseph; Gershow, M; Hammarlund, M.; Goodman, M. B.; Colon-Ramos, D. A.; Zhang, Y.; Samuel, Aravinthan DT (Proceedings of the National Academy of Sciences, 2014)
      The nematode Caenorhabditis elegans navigates toward a preferred temperature setpoint (Ts) determined by long-term temperature exposure. During thermotaxis, the worm migrates down temperature gradients at temperatures above ...
    • Biomechanical Analysis Of Gait Adaptation In The Nematode Caenorhabditis elegans 

      Fang-Yen, Christopher; Wyart, Matthieu; Xie, Julie; Kawai, Risa; Kodger, Thomas Edward; Chen, Sway; Wen, Quan; Samuel, Aravinthan DT (National Academy of Sciences, 2010)
      To navigate different environments, an animal must be able to adapt its locomotory gait to its physical surroundings. The nematode Caenorhabditis elegans, between swimming in water and crawling on surfaces, adapts its ...
    • Contrasting responses within a single neuron class enable sex-specific attraction in Caenorhabditis elegans 

      Narayan, Anusha; Venkatachalam, Vivek; Durak, Omer; Reilly, Douglas K.; Bose, Neelanjan; Schroeder, Frank C.; Samuel, Aravinthan DT; Srinivasan, Jagan; Sternberg, Paul W. (Proceedings of the National Academy of Sciences, 2016)
      Animals find mates and food, and avoid predators, by navigating to regions within a favorable range of available sensory cues. How are these ranges set and recognized? Here we show that male Caenorhabditis elegans exhibit ...
    • Controlling Airborne Cues to Study Small Animal Navigation 

      Gershow, Marc; Berck, Matthew E; Mathew, Dennis; Luo, Linjiao; Kane, Elizabeth Anne; Carlson, John R; Samuel, Aravinthan DT (Nature Publishing Group, 2012)
      Small animals such as nematodes and insects analyze airborne chemical cues to infer the direction of favorable and noxious locations. In these animals, the study of navigational behavior evoked by airborne cues has been ...
    • The Core Apoptotic Executioner Proteins CED-3 and CED-4 Promote Initiation of Neuronal Regeneration in Caenorhabditis elegans 

      Pinan-Lucarre, Berangere; Gabel, Christopher V.; Reina, Christopher P.; Hulme, S. Elizabeth; Shevkoplyas, Sergey S.; Slone, R. Daniel; Xue, Jian; Qiao, Yujie; Weisberg, Sarah; Roodhouse, Kevin; Whitesides, George M.; Samuel, Aravinthan DT; Driscoll, Monica (Public Library of Science, 2012)
      A critical accomplishment in the rapidly developing field of regenerative medicine will be the ability to foster repair of neurons severed by injury, disease, or microsurgery. In C. elegans, individual visualized axons ...
    • The Core Apoptotic Executioner Proteins CED-3 and CED-4 Promote Neuronal Regeneration in Caenorhabditis Elegans 

      Pinan-Lucarre, Berangere; Gabel, Christopher V.; Reina, Christopher P.; Hulme, S. Elizabeth; Shevkopylas, Sergey S.; Slone, R. Daniel; Xue, Jian; Qiao, Yujie; Weisberg, Sarah; Roodhouse, Kevin; Sun, Lin; Whitesides, George M.; Samuel, Aravinthan DT; Drisocll, Monica (Public Library of Science, 2012)
      A critical accomplishment in the rapidly developing field of regenerative medicine will be the ability to foster repair of neurons severed by injury, disease, or microsurgery. In C. elegans, individual visualized axons can ...
    • Dopamine Signaling Is Essential for Precise Rates of Locomotion by C. elegans 

      Omura, Daniel T.; Clark, Damon A.; Samuel, Aravinthan DT; Horvitz, H. Robert (Public Library of Science, 2012)
      Dopamine is an important neuromodulator in both vertebrates and invertebrates. We have found that reduced dopamine signaling can cause a distinct abnormality in the behavior of the nematode C. elegans, which has only eight ...
    • Envelope Structure of Synechococcus sp. WH8113, A Nonflagellated Swimming Cyanobacterium 

      Samuel, Aravinthan DT; Petersen, Jennifer D; Reese, Thomas S (BioMed Central, 2001)
      Background: Many bacteria swim by rotating helical flagellar filaments [1]. Waterbury et al. [15] discovered an exception, strains of the cyanobacterium Synechococcus that swim without flagella or visible changes in shape. ...
    • Functional diversity among sensory receptors in a Drosophila olfactory circuit 

      Mathew, Dennis; Martelli, Carlotta; Kelley-Swift, Elizabeth; Brusalis, Christopher; Gershow, Marc; Samuel, Aravinthan DT; Emonet, Thierry; Carlson, John R. (Proceedings of the National Academy of Sciences, 2013)
      The ability of an animal to detect, discriminate, and respond to odors depends on the function of its olfactory receptor neurons (ORNs), which in turn depends ultimately on odorant receptors. To understand the diverse ...
    • Functional Organization of a Neural Network for Aversive Olfactory Learning in Caenorhabditis elegans 

      Ha, Heon-ick; Hendricks, Michael Shelton; Shen, Yu Serena; Gabel, Christopher V.; Fang-Yen, Christopher M.; Qin, Yuqi; Shen, Kang; Zhang, Yun; Samuel, Aravinthan D. T.; Colón-Ramos, Daniel (Elsevier, 2010)
      Many animals use their olfactory systems to learn to avoid dangers, but how neural circuits encode naive and learned olfactory preferences, and switch between those preferences, is poorly understood. Here, we map an olfactory ...
    • Inexpensive Microscopy for Introductory Laboratory Courses 

      Peidle, Joseph D.; Stokes, Chris; Hart, Robert M; Franklin, Melissa; Newburgh, Ronald; Pahk, Joon; Rueckner, Wolfgang H. E.; Samuel, Aravinthan DT (American Association of Physics Teachers, 2009)
      We present an inexpensive apparatus for bright field and fluorescence microscopy with video capture, suitable for introductory laboratory courses. Experiments on Brownian motion and the Boltzmann distribution of suspended ...
    • Monoaminergic Orchestration of Motor Programs in a Complex C. elegans Behavior 

      Donnelly, Jamie L.; Clark, Christopher M.; Leifer, Andrew M.; Pirri, Jennifer K.; Haburcak, Marian; Francis, Michael M.; Samuel, Aravinthan DT; Alkema, Mark J. (Public Library of Science, 2013)
      Monoamines provide chemical codes of behavioral states. However, the neural mechanisms of monoaminergic orchestration of behavior are poorly understood. Touch elicits an escape response in Caenorhabditis elegans where the ...
    • Multimodal stimulus coding by a gustatory sensory neuron in Drosophila larvae 

      van Giesen, Lena; Hernandez-Nunez, Luis; Delasoie-Baranek, Sophie; Colombo, Martino; Renaud, Philippe; Bruggmann, Rémy; Benton, Richard; Samuel, Aravinthan D. T.; Sprecher, Simon G. (Nature Publishing Group, 2016)
      Accurate perception of taste information is crucial for animal survival. In adult Drosophila, gustatory receptor neurons (GRNs) perceive chemical stimuli of one specific gustatory modality associated with a stereotyped ...
    • Navigational Decision Making in Drosophila Thermotaxis 

      Luo, Linjiao; Gershow, Marc Herman; Rosenzweig, Mark; Kang, Kyeonglin; Fang-Yen, Christopher M.; Garrity, Paul A,; Samuel, Aravinthan DT (Society for Neuroscience, 2010)
      A mechanistic understanding of animal navigation requires quantitative assessment of the sensorimotor strategies used during navigation and quantitative assessment of how these strategies are regulated by cellular sensors. ...
    • Optogenetic Manipulation Of Neural Activity In Freely Moving Caenorhabditis elegans 

      Leifer, Andrew M.; Fang-Yen, Christopher; Gershow, Marc; Alkema, Mark; Samuel, Aravinthan DT (Nature Publishing Group, 2011)
      We present an optogenetic illumination system that is capable of real-time light delivery with high spatial resolution to specified cellular targets in freely moving C. elegans. In our system, a tracking microscope and ...
    • Pan-neuronal imaging in roaming Caenorhabditis elegans 

      Venkatachalam, Vivek; Ji, Ni; Wang, Xian-Ling; Clark, Christopher Luce; Mitchell, James Kameron; Klein, Mason Joseph; Tabone, Christopher; Florman, Jeremy; Ji, Hongfei; Greenwood, Joel S.f.; Chisholm, Andrew; Srinivasan, Jagan; Alkema, Mark; Zhen, Mei; Samuel, Aravinthan DT (Proceedings of the National Academy of Sciences, 2015)
      We present an imaging system for pan-neuronal recording in crawling Caenorhabditis elegans. A spinning disk confocal microscope, modified for automated tracking of the C. elegans head ganglia, simultaneously records the ...
    • Pathogen Avoidance by Caenorhabditis Elegans Is a Pheromone-Mediated Collective Behavior 

      Nowojewski, Andrzej Kazimierz (2015-01-12)
      A model organism Caenorhabditis elegans is a free-living nematode that feeds on bacteria in the wild. To survive, it has to be able to distinguish between benign and pathogenic microorganisms. Thanks to its simple neural ...
    • Proprioceptive Coupling within Motor Neurons Drives C. Elegans Forward Locomotion 

      Wen, Quan; Po, Michelle D.; Hulme, Elizabeth; Chen, Sway; Liu, Xinyu; Kwok, Sen Wai; Gershow, Marc; Leifer, Andrew M.; Butler, Victoria; Fang-Yen, Christopher; Kawano, Taizo; Schafer, William R.; Whitesides, George M.; Wyart, Matthieu; Chklovskii, Dmitri B.; Zhen, Mei; Samuel, Aravinthan DT (Elsevier BV, 2012)
      Locomotion requires coordinated motor activity throughout an animal’s body. In both vertebrates and invertebrates, chains of coupled central pattern generators (CPGs) are commonly evoked to explain local rhythmic behaviors. ...
    • Rapid and Permanent Neuronal Inactivation In Vivo via Subcellular Generation of Reactive Oxygen with the Use of KillerRed 

      Williams, Daniel C.; El Bejjani, Rachid; Ramirez, Paula Mugno; Coakley, Sean; Kim, Shin Ae; Lee, Hyewon; Wen, Quan; Samuel, Aravinthan DT; Lu, Hang; Hilliard, Massimo A.; Hammarlund, Marc (Elsevier BV, 2013)
      Inactivation of selected neurons in vivo can define their contribution to specific developmental outcomes, circuit functions, and behaviors. Here, we show that the optogenetic tool KillerRed selectively, rapidly, and ...