Now showing items 1-13 of 13

    • Cherubism: Best Clinical Practice 

      Papadaki, Maria E; Lietman, Steven A; Levine, Michael A.; Olsen, Bjorn Reino; Kaban, Leonard B.; Reichenberger, Ernst J (BioMed Central, 2012)
      Cherubism is a skeletal dysplasia characterized by bilateral and symmetric fibro-osseous lesions limited to the mandible and maxilla. In most patients, cherubism is due to dominant mutations in the SH3BP2 gene on chromosome ...
    • Critical Endothelial Regulation by LRP5 during Retinal Vascular Development 

      Huang, Wei; Li, Qing; Amiry-Moghaddam, Mahmood; Hokama, Madoka; Sardi, Sylvia H.; Nagao, Masashi; Warman, Matthew L.; Olsen, Bjorn R. (Public Library of Science, 2016)
      Vascular abnormalities in the eye are the leading cause of many forms of inherited and acquired human blindness. Loss-of-function mutations in the Wnt-binding co-receptor LRP5 leads to aberrant ocular vascularization and ...
    • Ecto-protein kinases and phosphatases: an emerging field for translational medicine 

      Yalak, Garif; Ehrlich, Yigal H; Olsen, Bjorn R (BioMed Central, 2014)
      Progress in translational research has led to effective new treatments of a large number of diseases. Despite this progress, diseases including cancer and cardiovascular disorders still are at the top in death statistics ...
    • An Evolutionarily Conserved Enhancer Regulates Bmp4 Expression in Developing Incisor and Limb Bud 

      Lachke, Salil A.; O’Connell, Daniel J.; Aboukhalil, Anton; Choe, Sung E.; Turbe-Doan, Annick; Robertson, Erin A.; Amendt, Brad A.; Jumlongras, Dolrudee; Li, Xiao; Ho, Joshua Wing Kei; Olsen, Bjorn Reino; Bulyk, Martha Leonia; Maas, Richard Louis (Public Library of Science, 2012)
      To elucidate the transcriptional regulation of Bmp4 expression during organogenesis, we used phylogenetic footprinting and transgenic reporter analyses to identify Bmp4 cis-regulatory modules (CRMs). These analyses identified ...
    • Polycystin-1 and Bone Mechanotransduction 

      Huang, Wei (2013-02-19)
      Bone mechanotransduction is a fundamental process underlying the remarkable ability of bones to perceive surrounding physical cues and adapt their mass, structure and overall strength to their mechanical environment. ...
    • Presphenoidal synchondrosis fusion in DBA/2J mice 

      Adams, Allysa Claire; McBratney-Owen, Brandeis; Newby, Brittany; Bowen, Margot Elizabeth; Olsen, Bjorn Reino; Warman, Matthew L. (Springer-Verlag, 2012)
      Cranial base growth plates are important centers of longitudinal growth in the skull and are responsible for the proper anterior placement of the face and the stimulation of normal cranial vault development. We report that ...
    • Proteomic database mining opens up avenues utilizing extracellular protein phosphorylation for novel therapeutic applications 

      Yalak, Garif; Olsen, Bjorn R (BioMed Central, 2015)
      Summary Recent advances in extracellular signaling suggest that extracellular protein phosphorylation is a regulatory mechanism outside the cell. The list of reported active extracellular protein kinases and phosphatases ...
    • Rapamycin Inhibits Proliferation of Hemangioma Endothelial Cells by Reducing HIF-1-Dependent Expression of VEGF 

      Medici, Damian; Olsen, Bjorn Reino (Public Library of Science, 2012)
      Hemangiomas are tumors formed by hyper-proliferation of vascular endothelial cells. This is caused by elevated vascular endothelial growth factor (VEGF) signaling through VEGF receptor 2 (VEGFR2). Here we show that elevated ...
    • Regulatory mechanisms of anthrax toxin receptor 1-dependent vascular and connective tissue homeostasis 

      Besschetnova, Tatiana Y.; Ichimura, Takaharu; Katebi, Negin; St. Croix, Brad; Bonventre, Joseph V.; Olsen, Bjorn R. (2015)
      It is well known that angiogenesis is linked to fibrotic processes in fibroproliferative diseases, but insights into pathophysiological processes are limited, due to lack of understanding of molecular mechanisms controlling ...
    • The Role of SH3BP2 in the Pathophysiology of Cherubism 

      Reichenberger, Ernst J; Levine, Michael A.; Olsen, Bjorn Reino; Papadaki, Maria E; Lietman, Steven A (BioMed Central, 2012)
      Cherubism is a rare bone dysplasia that is characterized by symmetrical bone resorption limited to the jaws. Bone lesions are filled with soft fibrous giant cell-rich tissue that can expand and cause severe facial deformity. ...
    • Skeletal defects in VEGF120/120 mice reveal multiple roles for VEGF in skeletogenesis 

      Zelzer, Elazar; McLean, William; Ng, Yin-Shan; Fukai, Naomi; Reginato, Anthony; Lovejoy, Stephanie; D'Amore, Patricia Ann; Olsen, Bjorn Reino (The Company of Biologists, 2002)
      Angiogenesis is an essential component of skeletal development and VEGF signaling plays an important if not pivotal role in this process. Previous attempts to examine the roles of VEGF in vivo have been largely unsuccessful ...
    • Thanks to all those who reviewed for Journal of Negative Results in Biomedicine in 2014 

      Olsen, Bjorn R; Brachvogel, Bent (BioMed Central, 2015)
      Contributing reviewers A peer-reviewed journal would not survive without the generous time and insightful comments of the reviewers, whose efforts often go unrecognized. Although final decisions are always editorial, they ...
    • Thanks to all those who reviewed for Journal of Negative Results in BioMedicine in 2015 

      Olsen, Bjorn R.; Mielenz, Dirk (BioMed Central, 2016)
      Contributing reviewers A peer-reviewed journal would not survive without the generous time and insightful comments of the reviewers, whose efforts often go unrecognized. Although final decisions are always editorial, they ...