Browsing by Author "Rosenzweig, Anthony"
Now showing items 1-6 of 6
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Ablation of SGK1 Impairs Endothelial Cell Migration and Tube Formation Leading to Decreased Neo-Angiogenesis Following Myocardial Infarction
Zarrinpashneh, Elham; Poggioli, Tommaso; Sarathchandra, Padmini; Lexow, Jonas; Monassier, Laurent; Terracciano, Cesare; Lang, Florian; Damilano, Federico; Zhou, Jessica Q.; Rosenzweig, Anthony; Rosenthal, Nadia; Santini, Maria Paola (Public Library of Science, 2013)Serum and glucocorticoid inducible kinase 1 (SGK1) plays a pivotal role in early angiogenesis during embryonic development. In this study, we sought to define the SGK1 downstream signalling pathways in the adult heart and ... -
IKK\(\beta\) Regulates Essential Functions of the Vascular Endothelium Through Kinase-Dependent and -Independent Pathways
Ashida, Noboru; SenBanerjee, Sucharita B.; Kodama, Shohta; Foo, Shi Yin; Coggins, Matthew Peter; Spencer, Joel A.; Zamiri, Parisa; Shen, Dongxiao; Li, Ling; Sciuto, Tracey; Dvorak, Ann Marie; Gerszten, Robert Edgardo; Lin, Charles P.; Karin, Michael; Rosenzweig, Anthony (Nature Publishing Group, 2011)Vascular endothelium provides a selective barrier between the blood and tissues, participates in wound healing and angiogenesis, and regulates tissue recruitment of inflammatory cells. Nuclear factor (NF)- \(\kappa\)B ... -
Phenotypic Spectrum Caused by Transgenic Overexpression of Activated Akt in the Heart
Matsui, Takashi; Li, Ling; Wu, Justina C.; Cook, Stuart; Nagoshi, Tomohisa; Picard, Michael Howard; Liao, Ronglih; Rosenzweig, Anthony (American Society for Biochemistry & Molecular Biology (ASBMB), 2002)The serine-threonine kinase, Akt, inhibits cardiomyocyte apoptosis acutely both in vitro and in vivo. However, the effects of chronic Akt activation in the heart are unknown. To address this issue, we generated transgenic ... -
Regulation of cardiac hypertrophy in vivo by the stress-activated protein kinases/c-Jun NH2-terminal kinases
Choukroun, Gabriel; Hajjar, Roger; Fry, Stefanie; Del Monte, Federica; Haq, Syed; Guerrero, J. Luis; Picard, Michael Howard; Rosenzweig, Anthony; Force, Thomas (American Society for Clinical Investigation, 1999)Cardiac hypertrophy often presages the development of heart failure. Numerous cytosolic signaling pathways have been implicated in the hypertrophic response in cardiomyocytes in culture, but their roles in the hypertrophic ... -
Three‐dimensional myocardial scarring along myofibers after coronary ischemia–reperfusion revealed by computerized images of histological assays
Katz, Monica Y.; Kusakari, Yoichiro; Aoyagi, Hiroko; Higa, Jason K.; Xiao, Chun‐Yang; Abdelkarim, Ahmed Z.; Marh, Karra; Aoyagi, Toshinori; Rosenzweig, Anthony; Lozanoff, Scott; Matsui, Takashi (Wiley Periodicals, Inc., 2014)Abstract Adverse left ventricular (LV) remodeling after acute myocardial infarction is characterized by LV dilatation and development of a fibrotic scar, and is a critical factor for the prognosis of subsequent development ... -
Traditional Chinese Medication Qiliqiangxin attenuates cardiac remodeling after acute myocardial infarction in mice
Tao, Lichan; Shen, Sutong; Fu, Siyi; Fang, Hongyi; Wang, Xiuzhi; Das, Saumya; Sluijter, Joost P. G.; Rosenzweig, Anthony; Zhou, Yonglan; Kong, Xiangqing; Xiao, Junjie; Li, Xinli (Nature Publishing Group, 2015)In a multicenter randomized double-blind study we demonstrated that Qiliqiangxin (QLQX), a traditional Chinese medicine, had a protective effect in heart failure patients. However, whether and via which mechanism QLQX ...