Browsing by Author "Corfas, Gabriel"
Now showing items 1-6 of 6
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The adhesion G protein-coupled receptor GPR56 is a cell-autonomous regulator of oligodendrocyte development
Giera, Stefanie; Deng, Yiyu; Luo, Rong; Ackerman, Sarah D.; Mogha, Amit; Monk, Kelly R.; Ying, Yanqin; Jeong, Sung-Jin; Makinodan, Manabu; Bialas, Allison R.; Chang, Bernard S.; Stevens, Beth; Corfas, Gabriel; Piao, Xianhua (Nature Pub. Group, 2015)Mutations in GPR56, a member of the adhesion G protein-coupled receptor family, cause a human brain malformation called bilateral frontoparietal polymicrogyria (BFPP). Magnetic resonance imaging (MRI) of BFPP brains reveals ... -
Astrocyte-Specific Disruption of SynCAM1 Signaling Results in ADHD-Like Behavioral Manifestations
Sandau, Ursula S.; Alderman, Zefora; Corfas, Gabriel; Ojeda, Sergio R.; Raber, Jacob (Public Library of Science, 2012)SynCAM1 is an adhesion molecule involved in synaptic differentiation and organization. SynCAM1 is also expressed in astroglial cells where it mediates astrocyte-to astrocyte and glial-neuronal adhesive communication. In ... -
Identification of Novel Glial Genes by Single-Cell Transcriptional Profiling of Bergmann Glial Cells from Mouse Cerebellum
Koirala, Samir; Corfas, Gabriel (Public Library of Science, 2010)Bergmann glial cells play critical roles in the structure and function of the cerebellum. During development, their radial processes serve as guides for migrating granule neurons and their terminal endfeet tile to form the ... -
Neurotrophin-3 regulates ribbon synapse density in the cochlea and induces synapse regeneration after acoustic trauma
Wan, Guoqiang; Gómez-Casati, Maria E; Gigliello, Angelica R; Liberman, M Charles; Corfas, Gabriel (eLife Sciences Publications, Ltd, 2014)Neurotrophin-3 (Ntf3) and brain derived neurotrophic factor (Bdnf) are critical for sensory neuron survival and establishment of neuronal projections to sensory epithelia in the embryonic inner ear, but their postnatal ... -
Tetrodotoxin-Bupivacaine-Epinephrine Combinations for Prolonged Local Anesthesia
Berde, Charles Benjamin; Athiraman, Umeshkumar; Yahalom, Barak; Zurakowski, David; Corfas, Gabriel; Bognet, Christina (Molecular Diversity Preservation International (MDPI), 2011)Currently available local anesthetics have analgesic durations in humans generally less than 12 hours. Prolonged-duration local anesthetics will be useful for postoperative analgesia. Previous studies showed that in rats, ... -
Two Stories of Neurodevelopment: Exosome-Mediated Secretion of Sonic Hedgehog and Somatic Mutation in Disorders of DNA Damage Repair
Coulter, Michael (2016-09-06)Human genetics of neonatal brain malformations has identified dozens of genes required for brain development that regulate diverse cellular processes. Recent evidence shows that somatic mutations, mutations that are only ...