Browsing by Author "Chan, Jennifer"

Now showing items 1-4 of 4

    • Analysis of the 10q11 Cancer Risk Locus Implicates MSMB and NCOA4 in Human Prostate Tumorigenesis 

      Chanock, Stephen J.; Schafer, Eric J.; Tabernero, Josep; Baselga, José; Oh, William K.; Pomerantz, Mark M; Shrestha, Yashaswi; Flavin, Richard John; Regan, Meredith Margaret; Penney, Kathryn Lee; Mucci, Lorelei Ann; Stampfer, Meir; Hunter, David J.; Chan, Jennifer Ang; Richardson, Andrea Lynn; Loda, Massimo; Kantoff, Philip Wayne; Hahn, William C.; Freedman, Matthew Lawrence (Public Library of Science, 2010)
      Genome-wide association studies (GWAS) have established a variant, rs10993994, on chromosome 10q11 as being associated with prostate cancer risk. Since the variant is located outside of a protein-coding region, the target ...

    • Ataxia, Dementia, and Hypogonadotropism Caused by Disordered Ubiquitination 

      Margolin, David H.; Kousi, Maria; Chan, Yee-Ming; Lim, Elaine T.; Schmahmann, Jeremy Dan; Hadjivassiliou, Marios; Hall, Janet E.; Adam, Ibrahim; Dwyer, Andrew; Plummer, Lacey; Aldrin, Stephanie V.; O, Julia; Kirby, Andrew; Lage, Kasper; Milunsky, Aubrey; Milunsky, Jeff M.; Chan, Jennifer Ang; Hedley-Whyte, E. Tessa; Daly, Mark Joseph; Katsanis, Nicholas; Seminara, Stephanie Beth (New England Journal of Medicine (NEJM/MMS), 2013)
      In recent years, we have seen great advances in the elucidation of genetic causes of cerebellar ataxia, with newly identified genes regulating a wide spectrum of cellular functions, including intracellular signaling, tau ...

    • CDK8 Is a Colorectal Cancer Oncogene That Regulates β-Catenin Activity 

      Firestein, Ron; Bass, Adam; Kim, So Young; Dunn, Ian Frederick; Silver, Serena J.; Guney, Isil; Freed, Ellen; Ligon, Azra Hadi; Vena, Natalie; Ogino, Shuji; Chheda, Milan; Tamayo, Pablo; Finn, Stephen; Shrestha, Yashaswi; Boehm, Jesse S.; Jain, Supriya Rani; Bojarski, Emeric; Mermel, Craig; Barretina, Jordi; Chan, Jennifer Ang; Baselga, Jose; Tabernero, Josep; Root, David E.; Fuchs, Charles Stewart; Loda, Massimo; Shivdasani, Ramesh Arjun; Meyerson, Matthew Langer; Hahn, William Chun (Springer Nature, 2008)
      Aberrant activation of the canonical Wnt/β-catenin pathway occurs in almost all colorectal cancers and contributes to their growth, invasion and survival. Although dysregulated β-catenin activity drives colon tumorigenesis, ...

    • Profiling Critical Cancer Gene Mutations in Clinical Tumor Samples 

      Campbell, Catarina D.; Kehoe, Sarah M.; Hatton, Charles; Niu, Lili; Yao, Keluo; Hanna, Megan; Mondal, Chandrani; Luongo, Lauren; Baker, Alissa C.; Philips, Juliet; Goff, Deborah J.; Rubin, Mark A.; Corso, Gianni; Roviello, Franco; MacConaill, Laura Eleanor; Bass, Adam Joel; Davis, Matthew J; Emery, Caroline Margaret; Fiorentino, Michelangelo; Polyak, Kornelia; Chan, Jennifer Ang; Wang, Yufang; Fletcher, Jonathan A.; Santagata, Sandro; Shivdasani, Ramesh Arjun; Kieran, Mark W.; Ligon, Keith Lloyd; Stiles, Charles Dean; Hahn, William C.; Meyerson, Matthew Langer; Garraway, Levi Alexander; Jones, Chris (Public Library of Science, 2009)
      Background: Detection of critical cancer gene mutations in clinical tumor specimens may predict patient outcomes and inform treatment options; however, high-throughput mutation profiling remains underdeveloped as a diagnostic ...