Now showing items 1-2 of 2

    • Global Epigenetic Regulation of MicroRNAs in Multiple Myeloma 

      Zhang, Wenjing; Wang, Yaoyu E.; Zhang, Yu; Leleu, Xavier; Reagan, Michaela; Zhang, Yong; Mishima, Yuji; Glavey, Siobhan; Manier, Salomon; Sacco, Antonio; Jiang, Bo; Roccaro, Aldo M.; Ghobrial, Irene M. (Public Library of Science, 2014)
      Epigenetic changes frequently occur during tumorigenesis and DNA hypermethylation may account for the inactivation of tumor suppressor genes in cancer cells. Studies in Multiple Myeloma (MM) have shown variable DNA methylation ...
    • Stem Cell Implants for Cancer Therapy: TRAIL-Expressing Mesenchymal Stem Cells Target Cancer Cells In Situ 

      Reagan, Michaela Ruth; Seib, F. Philipp; McMillin, Douglas William; Sage, Elizabeth K.; Mitsiades, Constantine S.; Janes, Sam M.; Ghobrial, Irene; Kaplan, David L. (Korean Breast Cancer Society, 2012)
      Purpose Tumor-specific delivery of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), an apoptosis-inducing peptide, at effective doses remains challenging. Herein we demonstrate the utility of a scaffold-based ...