Browsing by Author "Dumelin, Christoph"
Now showing items 1-3 of 3
-
Discovery and biological characterization of geranylated RNA in bacteria
Dumelin, Christoph; Chen, Yiyun; Leconte, Aaron M; Chen, Y Grace; Liu, David Ruchien (Nature Publishing Group, 2012)A general mass spectrometry-based screen for unusually hydrophobic cellular small-molecule RNA conjugates revealed geranylated RNA in E. coli, Enterobacter aerogenes, Pseudomonas aeruginosa, and Salmonella thyphimurium. ... -
In Vitro Selection of a DNA-Templated Small-Molecule Library Reveals a Class of Macrocyclic Kinase Inhibitors
Kleiner, Ralph Elliot; Dumelin, Christoph; Tiu, Gerald C.; Sakurai, Kaori; Liu, David Ruchien (American Chemical Society, 2010)DNA-templated organic synthesis enables the translation of DNA sequences into synthetic small-molecule libraries suitable for in vitro selection. Previously, we described the DNA-templated multistep synthesis of a ... -
Interaction-Dependent PCR: Identification of Ligand−Target Pairs from Libraries of Ligands and Libraries of Targets in a Single Solution-Phase Experiment
McGregor, Lynn Marie; Gorin, David Joel; Dumelin, Christoph; Liu, David Ruchien (American Chemical Society, 2010)Interaction-dependent PCR (IDPCR) is a solution-phase method to identify binding partners from combined libraries of small-molecule ligands and targets in a single experiment. Binding between DNA-linked targets and DNA-linked ...