Browsing by Author "Wong, Andrew M S"

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    • Behavioral deficits, early gliosis, dysmyelination and synaptic dysfunction in a mouse model of mucolipidosis IV 

      Grishchuk, Yulia; Sri, Sarmi; Rudinskiy, Nikita; Ma, Weiyuan; Stember, Katherine G; Cottle, Matthew W; Sapp, Ellen; Difiglia, Marian; Muzikansky, Alona; Betensky, Rebecca A; Wong, Andrew M S; Bacskai, Brian J; Hyman, Bradley T; Kelleher, Raymond J; Cooper, Jonathan D; Slaugenhaupt, Susan A (BioMed Central, 2014)
      Mucolipidosis IV (MLIV) is caused by mutations in the gene MCOLN1. Patients with MLIV have severe neurologic deficits and very little is known about the brain pathology in this lysosomal disease. Using an accurate mouse ...