Now showing items 1-5 of 5

    • Cancer nanotechnology: The impact of passive and active targeting in the era of modern cancer biology 

      Bertrand, Nicolas; Wu, Jun; Xu, Xiaoyang; Kamaly, Nazila; Farokhzad, Omid Cameron (Elsevier BV, 2014)
      Cancer nanotherapeutics are progressing at a steady rate; research and development in the field has experienced an exponential growth since early 2000’s. The path to the commercialization of oncology drugs is long and ...
    • Development of Multinuclear Polymeric Nanoparticles as Robust Protein Nanocarriers 

      Wu, Jun; Kamaly, Nazila; Shi, Jinjun; Zhao, Lili; Xiao, Zeyu; Hollett, Geoffrey; John, Rohit; Ray, Shaunak; Xu, Xiaoyang; Zhang, Xueqing; Kantoff, Philip Wayne; Farokhzad, Omid Cameron (Wiley-Blackwell, 2014)
      One limitation of current biodegradable polymeric nanoparticles is their inability to effectively encapsulate and sustainably release proteins while maintaining protein bioactivity. Here we report the engineering of a ...
    • Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits 

      Speliotes, Elizabeth K.; Yerges-Armstrong, Laura M.; Hernaez, Ruben; Gudnason, Vilmundur; Eiriksdottir, Gudny; Garcia, Melissa E.; Launer, Lenore J.; Nalls, Michael A.; Clark, Jeanne M.; Mitchell, Braxton D.; Shuldiner, Alan R.; Butler, Johannah L.; Tomas, Marta; Hwang, Shih-Jen; Massaro, Joseph M.; Salomaa, Veikko; Schadt, Eric E.; Schwartz, Stephen M.; Siscovick, David S.; Voight, Benjamin F.; Feitosa, Mary F.; Harris, Tamara B.; Smith, Albert V.; Borecki, Ingrid B.; Wu, Jun; Kim, Lauren J.; Palmer, Cameron D.; Hoffmann, Udo; Sahani, Dushyant V.; Carr, J. Jeffrey; Fox, Caroline; Kao, W. H. Linda; Hirschhorn, Joel Naom; O'Donnell, Christopher Joseph; NASH CRN; GIANT Consortium; MAGIC Investigators (Public Library of Science, 2011)
      Nonalcoholic fatty liver disease (NAFLD) clusters in families, but the only known common genetic variants influencing risk are near PNPLA3. We sought to identify additional genetic variants influencing NAFLD using genome-wide ...
    • Hybrid lipid–polymer nanoparticles for sustained siRNA delivery and gene silencing 

      Shi, Jinjun; Xu, Yingjie; Xu, Xiaoyang; Zhu, Xi; Pridgen, Eric; Wu, Jun; Votruba, Alexander R.; Swami, Archana; Zetter, Bruce Robert; Farokhzad, Omid Cameron (Elsevier BV, 2014)
      The development of controlled-release nanoparticle (NP) technologies has great potential to further improve the therapeutic efficacy of RNA interference (RNAi), by prolonging the release of small interfering RNA (siRNA) ...
    • A PGC1-\(\alpha\)-dependent Myokine that Drives Brown-fat-like Development of White Fat and Thermogenesis 

      Boström, Pontus; Wu, Jun; Jedrychowski, Mark P.; Korde, Anisha; Ye, Li; Lo, James C; Rasbach, Kyle A.; Boström, Elisabeth Almer; Choi, Jang Hyun; Long, Jonathan Zhong; Kajimura, Shingo; Zingaretti, Maria Cristina; Vind, Birgitte F.; Tu, Hua; Cinti, Saverio; Højlund, Kurt; Gygi, Steven P.; Spiegelman, Bruce Michael (Nature Publishing Group, 2012)
      Exercise benefits a variety of organ systems in mammals, and some of the best-recognized effects of exercise on muscle are mediated by the transcriptional co-activator PPAR-γ co-activator-1 α (PGC1-α). Here we show in mouse ...