Now showing items 1-20 of 34

    • Age-dependent postoperative cognitive impairment and Alzheimer-related neuropathology in mice 

      Xu, Zhipeng; Dong, Yuanlin; Wang, Hui; Culley, Deborah J.; Marcantonio, Edward R.; Crosby, Gregory; Tanzi, Rudolph E.; Zhang, Yiying; Xie, Zhongcong (Nature Publishing Group, 2014)
      Post-operative cognitive dysfunction (POCD) is associated with increased cost of care, morbidity, and mortality. However, its pathogenesis remains largely to be determined. Specifically, it is unknown why elderly patients ...
    • Aging, brain disease, and reserve: Implications for delirium 

      Jones, Richard Norman; Fong, Tamara G; Metzger, Eran Daniel; Tulebaev, Samir Raisovich; Yang, Frances Margaret; Alsop, David C.; Marcantonio, Edward Ralph; Cupples, L; Gottlieb, Gary L.; Inouye, Sharon (2010)
      Cognitive and brain reserve are well studied in the context of age-associated cognitive impairment and dementia. However, there is a paucity of research that examines the role of cognitive or brain reserve in delirium. ...
    • Battery of behavioral tests in mice to study postoperative delirium 

      Peng, Mian; Zhang, Ce; Dong, Yuanlin; Zhang, Yiying; Nakazawa, Harumasa; Kaneki, Masao; Zheng, Hui; Shen, Yuan; Marcantonio, Edward R.; Xie, Zhongcong (Nature Publishing Group, 2016)
      Postoperative delirium is associated with increased morbidity, mortality and cost. However, its neuropathogenesis remains largely unknown, partially owing to lack of animal model(s). We therefore set out to employ a battery ...
    • The CAM-S: Development and Validation of a New Scoring System for Delirium Severity in 2 Cohorts 

      Inouye, Sharon; Kosar, Cyrus M.; Tommet, Douglas; Schmitt, Eva M.; Puelle, Margaret R.; Saczynski, Jane S.; Marcantonio, Edward Ralph; Jones, Richard Norman (American College of Physicians, 2014)
    • Cholinergic Deficiency Hypothesis in Delirium: A Synthesis of Current Evidence 

      Hshieh, Tammy Ting; Fong, Tamara G; Marcantonio, Edward Ralph; Inouye, Sharon (Oxford University Press (OUP), 2008)
      Deficits in cholinergic function have been postulated to cause delirium and cognitive decline. This review examines current understanding of the cholinergic deficiency hypothesis in delirium by synthesizing evidence on ...
    • Cognitive and Physical Demands of Activities of Daily Living In Older Adults: Validation of Expert Panel Ratings: The SAGES Functional Measures Working Group 

      Fong, Tamara G.; Gleason, Lauren J.; Wong, Bonnie; Habtemariam, Daniel; Jones, Richard N.; Schmitt, Eva M.; de Rooij, Sophia E.; Saczynski, Jane S.; Gross, Alden L.; Bean, Jonathan F.; Brown, Cynthia J.; Fick, Donna M.; Gruber-Baldini, Ann L.; O’Connor, Margaret; Tabloski, Patrica A.; Marcantonio, Edward R.; Inouye, Sharon K. (2015)
      Background: Difficulties with performance of functional activities may result from cognitive and/or physical impairments. To date, there has not been a clear delineation of the physical and cognitive demands of activities ...
    • Cognitive Trajectories after Postoperative Delirium 

      Saczynski, Jane S.; Marcantonio, Edward Ralph; Quach, Lien; Fong, Tamara G; Gross, Alden; Inouye, Sharon; Jones, Richard Norman (New England Journal of Medicine (NEJM/MMS), 2012)
      Background Delirium is common after cardiac surgery and may be associated with long-term changes in cognitive function. We examined postoperative delirium and the cognitive trajectory during the first year after cardiac ...
    • Delirium is associated with early postoperative cognitive dysfunction 

      Rudolph, James; Marcantonio, Edward Ralph; Culley, Deborah Jean; Silverstein, J. H.; Rasmussen, L. S.; Crosby, Gregory; Inouye, Sharon (Wiley-Blackwell, 2008)
      The purpose of this analysis was to determine if postoperative delirium was associated with early postoperative cognitive dysfunction (at 7 days) and long-term postoperative cognitive dysfunction (at 3 months). The ...
    • Delirium Severity Post-Surgery and its Relationship with Long-Term Cognitive Decline in a Cohort of Patients without Dementia 

      Vasunilashorn, Sarinnapha; Fong, Tamara G; Albuquerque, Asha; Marcantonio, Edward Ralph; Schmitt, Eva M.; Tommet, Douglas; Gou, Yun; Travison, Thomas G; Jones, Richard N.; Inouye, Sharon K. (IOS Press, 2017)
      Background: Delirium has been associated with more rapid cognitive decline. However, it is unknown whether increased delirium severity is associated with a higher rate of long-term cognitive decline. Objective: To evaluate ...
    • Delirium: An Independent Predictor of Functional Decline After Cardiac Surgery 

      Rudolph, James; Inouye, Sharon; Jones, Richard N.; Yang, Frances Margaret; Fong, Tamara G; Levkoff, Sue E.; Marcantonio, Edward Ralph (Wiley-Blackwell, 2010)
      OBJECTIVES: To determine whether patients who developed delirium after cardiac surgery were at risk of functional decline. DESIGN: Prospective cohort study. SETTING: Two academic hospitals and a Veterans Affairs ...
    • Derivation and Validation of a Preoperative Prediction Rule for Delirium After Cardiac Surgery 

      Rudolph, James; Jones, Richard Norman; Levkoff, Sue E.; Rockett, C.; Inouye, Sharon; Sellke, F. W.; Khuri, S. F.; Lipsitz, Lewis Arnold; Ramlawi, B.; Levitsky, Sidney; Marcantonio, Edward Ralph (Ovid Technologies (Wolters Kluwer Health), 2008)
      Background— Delirium is a common outcome after cardiac surgery. Delirium prediction rules identify patients at risk for delirium who may benefit from targeted prevention strategies, early identification, and treatment of ...
    • Development of a unidimensional composite measure of neuropsychological functioning in older cardiac surgery patients with good measurement precision 

      Jones, Richard Norman; Rudolph, James; Inouye, Sharon; Yang, Frances Margaret; Fong, Tamara G; Milberg, William Paul; Tommet, Douglas; Metzger, Eran Daniel; Cupples, L. Adrienne; Marcantonio, Edward Ralph (Informa UK Limited, 2010)
      The objective of this analysis was to develop a measure of neuropsychological performance for cardiac surgery and to assess its psychometric properties. Older patients (n = 210) underwent a neuropsychological battery using ...
    • Different MMSE Score Is Associated with Postoperative Delirium in Young-Old and Old-Old Adults 

      Wu, Yujie; Shi, Zhongyong; Wang, Meijuan; Zhu, Yingbo; Li, Cheng; Li, Guodong; Marcantonio, Edward R.; Xie, Zhongcong; Shen, Yuan (Public Library of Science, 2015)
      Background: Postoperative delirium is one of the most common postoperative complications in geriatric patients. Mini-mental state examination (MMSE) assesses cognitive function in patients and is associated with postoperative ...
    • Factors Influencing Elderly Women's Mammography Screening Decisions: Implications for Counseling 

      Schonberg, Mara Ann; McCarthy, Ellen Patricia; York, Meghan; Davis, Roger B.; Marcantonio, Edward Ralph (BioMed Central, 2007)
      Background: Although guidelines recommend that clinicians consider life expectancy before screening older women for breast cancer, many older women with limited life expectancies are screened. We aimed to identify factors ...
    • Identifying Indicators of Important Diagnostic Features of Delirium 

      Huang, Li-Wen; Inouye, Sharon; Jones, Richard Norman; Fong, Tamara G; Rudolph, James; O, Margaret G.; Metzger, Eran Daniel; Crane, Paul K.; Marcantonio, Edward Ralph (Wiley-Blackwell, 2012)
      OBJECTIVES: To use an expert consensus process to identify indicators of delirium features to help enhance bedside recognition of delirium. DESIGN: Modified Delphi consensus process to assign existing cognitive and ...
    • Independent Vascular and Cognitive Risk Factors for Postoperative Delirium 

      Rudolph, James; Jones, Richard Norman; Rasmussen, Lars S.; Silverstein, Jeffrey H.; Inouye, Sharon; Marcantonio, Edward Ralph (Elsevier BV, 2007)
    • The Language of Delirium: Keywords for Identifying Delirium from Medical Records 

      Puelle, Margaret R.; Kosar, Cyrus M.; Xu, Guoquan; Schmitt, Eva; Jones, Richard N.; Marcantonio, Edward Ralph; Cooper, Zara R; Inouye, Sharon K.; Saczynski, Jane S. (SLACK, Inc., 2015)
      Electronic medical records (EMRs) offer the opportunity to streamline the search for patients with possible delirium. The purpose of the current study was to identify words and phrases commonly noted in charts of patients ...
    • Maximizing Clinical Research Participation in Vulnerable Older Persons: Identification of Barriers and Motivators 

      Marcantonio, Edward Ralph; Aneja, Jasneet; Jones, Richard Norman; Alsop, David C.; Fong, Tamara G; Crosby, Gregory; Culley, Deborah Jean; Cupples, L. Adrienne; Inouye, Sharon (Wiley-Blackwell, 2008)
      OBJECTIVES: To identify barriers and motivators to participation in long-term clinical research by high-risk elderly people and to develop procedures to maximize recruitment and retention. DESIGN: Quantitative and ...
    • Novel Risk Markers and Long-Term Outcomes of Delirium: The Successful Aging after Elective Surgery (SAGES) Study Design and Methods 

      Schmitt, Eva M.; Marcantonio, Edward Ralph; Alsop, David C.; Jones, Richard Norman; Rogers, Selwyn O.; Fong, Tamara G; Metzger, Eran Daniel; Inouye, Sharon (Elsevier BV, 2012)
      Objectives: Delirium, a costly, life-threatening, and potentially preventable condition, is a common complication for older adults following major surgery. Although the basic epidemiology of delirium after surgery has been ...
    • One-Year Health Care Costs Associated With Delirium in the Elderly Population 

      Leslie, Douglas L.; Marcantonio, Edward Ralph; Zhang, Ying; Leo-Summers, Linda; Inouye, Sharon (American Medical Association (AMA), 2008)