Now showing items 1-20 of 44

    • Age-dependent postoperative cognitive impairment and Alzheimer-related neuropathology in mice 

      Xu, Zhipeng; Dong, Yuanlin; Wang, Hui; Culley, Deborah J.; Marcantonio, Edward R.; Crosby, Gregory; Tanzi, Rudolph E.; Zhang, Yiying; Xie, Zhongcong (Nature Publishing Group, 2014)
      Post-operative cognitive dysfunction (POCD) is associated with increased cost of care, morbidity, and mortality. However, its pathogenesis remains largely to be determined. Specifically, it is unknown why elderly patients ...
    • Aging, brain disease, and reserve: Implications for delirium 

      Jones, Richard Norman; Fong, Tamara G; Metzger, Eran Daniel; Tulebaev, Samir Raisovich; Yang, Frances Margaret; Alsop, David C.; Marcantonio, Edward Ralph; Cupples, L; Gottlieb, Gary L.; Inouye, Sharon (2010)
      Cognitive and brain reserve are well studied in the context of age-associated cognitive impairment and dementia. However, there is a paucity of research that examines the role of cognitive or brain reserve in delirium. ...
    • Aging, Brain Disease, and Reserve: Implications for Delirium 

      Jones, Richard; Fong, Tamara; Metzger, Eran; Tulebaev, Samir; Yang, Frances; Alsop, David; Marcantonio, Edward; Cupples, L Adrienne; Gottlieb, Gary; Inouye, Sharon (Elsevier BV, 2010-02)
      Cognitive and brain reserve are well studied in the context of age-associated cognitive impairment and dementia. However, there is a paucity of research that examines the role of cognitive or brain reserve in delirium. ...
    • Alzheimer's-Related Cortical Atrophy Is Associated With Postoperative Delirium Severity in Persons Without Dementia 

      Racine, Annie M.; Fong, Tamara; Travison, Thomas; Jones, Richard N.; Gou, Yun; Vasunilashorn, Sarinnapha; Marcantonio, Edward; Alsop, David; Inouye, Sharon; Dickerson, Bradford (Elsevier BV, 2017-11)
      Patients with dementia due to Alzheimer’s disease (AD) have increased risk of developing delirium. This study investigated the relationship between a magnetic resonance imaging (MRI)-derived biomarker associated with ...
    • Association Between Hospital Readmission and Acute and Sustained Delays in Functional Recovery During 18 Months After Elective Surgery: The Successful Aging after Elective Surgery Study 

      Pisani, Margaret A.; Albuquerque, Asha; Marcantonio, Edward; Jones, Richard N.; Gou, Ray Yun; Fong, Tamara; Schmitt, Eva M.; Tommet, Douglas; Isaza Aizpurua, Ilean I.; Alsop, David; Inouye, Sharon; Travison, Thomas (Wiley, 2017-01)
      Objectives: To examine the effect of hospital readmission on functional recovery after elective surgery in older adults. Design: Prospective cohort of individuals aged 70 and older undergoing elective surgery, enrolled ...
    • Battery of behavioral tests in mice to study postoperative delirium 

      Peng, Mian; Zhang, Ce; Dong, Yuanlin; Zhang, Yiying; Nakazawa, Harumasa; Kaneki, Masao; Zheng, Hui; Shen, Yuan; Marcantonio, Edward R.; Xie, Zhongcong (Nature Publishing Group, 2016)
      Postoperative delirium is associated with increased morbidity, mortality and cost. However, its neuropathogenesis remains largely unknown, partially owing to lack of animal model(s). We therefore set out to employ a battery ...
    • The CAM-S: Development and Validation of a New Scoring System for Delirium Severity in 2 Cohorts 

      Inouye, Sharon; Kosar, Cyrus M.; Tommet, Douglas; Schmitt, Eva M.; Puelle, Margaret R.; Saczynski, Jane S.; Marcantonio, Edward Ralph; Jones, Richard Norman (American College of Physicians, 2014)
    • Cholinergic Deficiency Hypothesis in Delirium: A Synthesis of Current Evidence 

      Hshieh, Tammy Ting; Fong, Tamara G; Marcantonio, Edward Ralph; Inouye, Sharon (Oxford University Press (OUP), 2008)
      Deficits in cholinergic function have been postulated to cause delirium and cognitive decline. This review examines current understanding of the cholinergic deficiency hypothesis in delirium by synthesizing evidence on ...
    • Cognitive and Brain Reserve and the Risk of Postoperative Delirium in Older Patients: Analysis of Data From a Prospective Observational Study 

      Saczynski, Jane; Inouye, Sharon; Kosar, Cyrus; Tommet, Doug; Marcantonio, Edward; Fong, Tamara; Hshieh, Tammy; Vasunilashorn, Sarinnapha; Metzger, Eran; Schmitt, Eva; Alsop, David; Jones, Richard N (Elsevier BV, 2014-11-01)
      Background Cognitive and brain reserve theories suggest that aspects of neural architecture or cognitive processes modify the impact of neuropathological processes on cognitive outcomes. While frequently studied in the ...
    • Cognitive and Physical Demands of Activities of Daily Living In Older Adults: Validation of Expert Panel Ratings: The SAGES Functional Measures Working Group 

      Fong, Tamara G.; Gleason, Lauren J.; Wong, Bonnie; Habtemariam, Daniel; Jones, Richard N.; Schmitt, Eva M.; de Rooij, Sophia E.; Saczynski, Jane S.; Gross, Alden L.; Bean, Jonathan F.; Brown, Cynthia J.; Fick, Donna M.; Gruber-Baldini, Ann L.; O’Connor, Margaret; Tabloski, Patrica A.; Marcantonio, Edward R.; Inouye, Sharon K. (2015)
      Background: Difficulties with performance of functional activities may result from cognitive and/or physical impairments. To date, there has not been a clear delineation of the physical and cognitive demands of activities ...
    • Cognitive Trajectories after Postoperative Delirium 

      Saczynski, Jane S.; Marcantonio, Edward Ralph; Quach, Lien; Fong, Tamara G; Gross, Alden; Inouye, Sharon; Jones, Richard Norman (New England Journal of Medicine (NEJM/MMS), 2012)
      Background Delirium is common after cardiac surgery and may be associated with long-term changes in cognitive function. We examined postoperative delirium and the cognitive trajectory during the first year after cardiac ...
    • Delirium Burden in Patients and Family Caregivers: Development and Testing of New Instruments 

      Racine, Anne; D’Aquila, Madeline; Schmitt, Eva M.; Gallagher, Jacqueline; Marcantonio, Edward; Jones, Richard N; Inouye, Sharon; Schulman-Green, Dena (Oxford University Press (OUP), 2018-05-08)
      BACKGROUND AND OBJECTIVES: Delirium creates distinct emotional distress in patients and family caregivers, yet there are limited tools to assess the experience. Our objective was to develop separate patient and family ...
    • Delirium is associated with early postoperative cognitive dysfunction 

      Rudolph, James; Marcantonio, Edward Ralph; Culley, Deborah Jean; Silverstein, J. H.; Rasmussen, L. S.; Crosby, Gregory; Inouye, Sharon (Wiley-Blackwell, 2008)
      The purpose of this analysis was to determine if postoperative delirium was associated with early postoperative cognitive dysfunction (at 7 days) and long-term postoperative cognitive dysfunction (at 3 months). The ...
    • Delirium Severity Post-Surgery and its Relationship with Long-Term Cognitive Decline in a Cohort of Patients without Dementia 

      Vasunilashorn, Sarinnapha; Fong, Tamara G; Albuquerque, Asha; Marcantonio, Edward Ralph; Schmitt, Eva M.; Tommet, Douglas; Gou, Yun; Travison, Thomas G; Jones, Richard N.; Inouye, Sharon K. (IOS Press, 2017)
      Background: Delirium has been associated with more rapid cognitive decline. However, it is unknown whether increased delirium severity is associated with a higher rate of long-term cognitive decline. Objective: To evaluate ...
    • Delirium: An Independent Predictor of Functional Decline After Cardiac Surgery 

      Rudolph, James; Inouye, Sharon; Jones, Richard N.; Yang, Frances Margaret; Fong, Tamara G; Levkoff, Sue E.; Marcantonio, Edward Ralph (Wiley-Blackwell, 2010)
      OBJECTIVES: To determine whether patients who developed delirium after cardiac surgery were at risk of functional decline. DESIGN: Prospective cohort study. SETTING: Two academic hospitals and a Veterans Affairs ...
    • Derivation and Validation of a Preoperative Prediction Rule for Delirium After Cardiac Surgery 

      Rudolph, James; Jones, Richard Norman; Levkoff, Sue E.; Rockett, C.; Inouye, Sharon; Sellke, F. W.; Khuri, S. F.; Lipsitz, Lewis Arnold; Ramlawi, B.; Levitsky, Sidney; Marcantonio, Edward Ralph (Ovid Technologies (Wolters Kluwer Health), 2008)
      Background— Delirium is a common outcome after cardiac surgery. Delirium prediction rules identify patients at risk for delirium who may benefit from targeted prevention strategies, early identification, and treatment of ...
    • Development of a unidimensional composite measure of neuropsychological functioning in older cardiac surgery patients with good measurement precision 

      Jones, Richard Norman; Rudolph, James; Inouye, Sharon; Yang, Frances Margaret; Fong, Tamara G; Milberg, William Paul; Tommet, Douglas; Metzger, Eran Daniel; Cupples, L. Adrienne; Marcantonio, Edward Ralph (Informa UK Limited, 2010)
      The objective of this analysis was to develop a measure of neuropsychological performance for cardiac surgery and to assess its psychometric properties. Older patients (n = 210) underwent a neuropsychological battery using ...
    • Different MMSE Score Is Associated with Postoperative Delirium in Young-Old and Old-Old Adults 

      Wu, Yujie; Shi, Zhongyong; Wang, Meijuan; Zhu, Yingbo; Li, Cheng; Li, Guodong; Marcantonio, Edward R.; Xie, Zhongcong; Shen, Yuan (Public Library of Science, 2015)
      Background: Postoperative delirium is one of the most common postoperative complications in geriatric patients. Mini-mental state examination (MMSE) assesses cognitive function in patients and is associated with postoperative ...
    • Effects of Arterial Transit Delay on Cerebral Blood Flow Quantification Using Arterial Spin Labeling in an Elderly Cohort 

      Dai, Weiying; Fong, Tamara; Jones, Richard N.; Marcantonio, Edward; Schmitt, Eva; Inouye, Sharon; Alsop, David (Wiley, 2017-02)
      Purpose This study is to investigate whether measurement of arterial transit time (ATT) can improve the accuracy of Arterial Spin Labeling (ASL) cerebral blood flow (CBF) quantification in an elderly cohort due to the ...
    • Factors Influencing Elderly Women's Mammography Screening Decisions: Implications for Counseling 

      Schonberg, Mara Ann; McCarthy, Ellen Patricia; York, Meghan; Davis, Roger B.; Marcantonio, Edward Ralph (BioMed Central, 2007)
      Background: Although guidelines recommend that clinicians consider life expectancy before screening older women for breast cancer, many older women with limited life expectancies are screened. We aimed to identify factors ...