Now showing items 1-17 of 17

    • Balancing the benefits of n-3 polyunsaturated fatty acids and the risks of methylmercury exposure from fish consumption 

      Mahaffey, Kathryn R; Sunderland, Elynor M; Chan, Hing Man; Choi, Anna; Grandjean, Philippe; Mariën, Koenraad; Oken, Emily; Sakamoto, Mineshi; Schoeny, Rita; Weihe, Pál; Yan, Chong-Huai; Yasutake, Akira (Oxford University Press (OUP), 2011)
      Fish and shellfish are widely available foods that provide important nutrients, particularly n-3 polyunsaturated fatty acids (n-3 PUFAs), to many populations globally. These nutrients, especially docosahexaenoic acid, ...
    • Developmental Fluoride Neurotoxicity: A Systematic Review and Meta-Analysis 

      Choi, Anna L.; Sun, Guifan; Zhang, Ying; Grandjean, Philippe (National Institute of Environmental Health Sciences, 2012)
      Background: Although fluoride may cause neurotoxicity in animal models and acute fluoride poisoning causes neurotoxicity in adults, very little is known of its effects on children’s neurodevelopment. Objective: We performed ...
    • Developmental Fluoride Neurotoxicity: Choi et al. Respond 

      Choi, Anna Lai; Grandjean, Philippe; Sun, Guifan; Zhang, Ying (Environmental Health Perspectives, 2013)
    • Does Living Near a Superfund Site Contribute to Higher Polychlorinated Biphenyl (PCB) Exposure? 

      Tolbert, Paige E.; Choi, Anna L; Choi, Anna Lai; Levy, Jonathan Ian; Dockery, Douglas W.; Ryan, Louise Marie; Altshul, Larisa; Korrick, Susan Abigail (National Institute of Environmental Health Sciences, 2006)
      We assessed determinants of cord serum polychlorinated biphenyl (PCB) levels among 720 infants born between 1993 and 1998 to mothers living near a PCB-contaminated Superfund site in Massachusetts, measuring the sum of 51 ...
    • Effect of seafood mediated PCB exposure on desaturase activity and PUFA profile in Faroese septuagenarians 

      Tøttenborg, Sandra Søgaard; Choi, Anna; Bjerve, Kristian S.; Weihe, Pal; Grandjean, Philippe (Elsevier BV, 2015)
      Polychlorinated biphenyl (PCB) exposure may affect serum concentrations of polyunsaturated fatty acids (PUFAs) by inhibiting desaturases Δ5 and Δ6 that drive their synthesis from precursor fatty acids. Such changes in the ...
    • Evidence on the Human Health Effects of Low Level Methylmercury Exposure 

      Karagas, Margaret R.; Choi, Anna Lai; Oken, Emily; Horvat, Milena; Schoeny, Rita; Kamai, Elizabeth; Cowell, Whitney J; Grandjean, Philippe; Korrick, Susan Abigail (2012)
      Background: Methylmercury (MeHg) is a known neurotoxicant. Emerging evidence indicates it may have adverse effects on the neurologic and other body systems at common low levels of exposure. Impacts of MeHg exposure could ...
    • Evidence on the Human Health Effects of Low-Level Methylmercury Exposure 

      Karagas, Margaret R.; Choi, Anna Lai; Oken, Emily; Horvat, Milena; Schoeny, Rita; Kamai, Elizabeth; Cowell, Whitney; Grandjean, Philippe; Korrick, Susan Abigail (National Institute of Environmental Health Sciences, 2012)
      Background: Methylmercury (MeHg) is a known neuro-toxicant. Emerging evidence indicates it may have adverse effects on the neurologic and other body systems at common low levels of exposure. Impacts of MeHg exposure could ...
    • Marine Food Pollutants as a Risk Factor for Hypoinsulinemia and Type 2 Diabetes 

      Grandjean, Philippe; Henriksen, Jan Erik; Choi, Anna Lai; Petersen, Maria Skaalum; Dalgård, Christine; Nielsen, Flemming; Weihe, Pal (Ovid Technologies (Wolters Kluwer Health), 2011)
      Background: Some persistent environmental chemicals are suspected of causing an increased risk of type 2 diabetes mellitus, a disease particularly common after the age of 70. This concern was examined in a cross-sectional ...
    • Methylmercury Exposure and Adverse Cardiovascular Effects in Faroese Whaling Men 

      Choi, Anna Lai; Weihe, Pal; Budtz-Jørgensen, Esben; Jørgensen, Poul J.; Salonen, Jukka T.; Tuomainen, Tomi-Pekka; Murata, Katsuyuki; Nielsen, Hans Petur; Petersen, Maria Skaalum; Askham, Jórun; Grandjean, Philippe (National Institute of Environmental Health Sciences, 2008)
      Background: Methylmercury (MeHg), a worldwide contaminant found in fish and seafood, has been linked to an increased risk of cardiovascular mortality. Objective: We examined 42 Faroese whaling men (30–70 years of age) to ...
    • Negative confounding by essential fatty acids in methylmercury neurotoxicity associations 

      Choi, Anna; Mogensen, Ulla B.; Bjerve, Kristian S.; Debes, Frodi; Weihe, Pal; Grandjean, Philippe; Budtz-Jørgensen, Esben (Elsevier BV, 2014)
      Background Methylmercury, a worldwide contaminant of fish and seafood, can cause adverse effects on the developing nervous system. However, long-chain n-3 polyunsaturated fatty acids in seafood provide beneficial effects ...
    • Neurotoxicity from prenatal and postnatal exposure to methylmercury 

      Grandjean, Philippe; Weihe, Pal; Debes, Frodi; Choi, Anna; Budtz-Jørgensen, Esben (Elsevier BV, 2014)
      The extent to which postnatal methylmercury exposure contributes to neurobehavioral delays is uncertain. Confounding may occur because the child's dietary exposure likely correlates with the mother's. This conundrum was ...
    • Persistent Organic Pollutants and Type 2 Diabetes: A Prospective Analysis in the Nurses’ Health Study and Meta-analysis 

      Wu, H; Bertrand, Kimberly Anne; Choi, Anna Lai; Hu, Frank B.; Laden, Francine; Grandjean, Philippe; Sun, Qi (National Institute of Environmental Health Sciences, 2013)
      BACKGROUND: Prospective data regarding persistent organic pollutants (POPs) and risk of type 2 diabetes (T2D) are limited, and the results for individual POPs are not entirely consistent across studies. OBJECTIVES: We ...
    • Plasma Levels of Persistent Organic Pollutants and Risk of Type 2 Diabetes: a Prospective Analysis in the Nurses’ Health Study and Meta-analysis 

      Wu, Hongyu; Bertrand, Kimberly Anne; Choi, Anna Lai; Hu, Frank B.; Laden, Francine; Grandjean, Philippe; Sun, Qi (National Institute of Environmental Health Sciences, 2013)
      Background: Prospective data regarding persistent organic pollutants (POPs) and risk of type 2 diabetes (T2D) are limited, and the results for individual POPs are not entirely consistent across studies. Objectives: We ...
    • Prenatal Organochlorine Exposure and Measures of Behavior in Infancy Using the Neonatal Behavioral Assessment Scale (NBAS) 

      Sagiv, Sharon; Nugent, J. Kevin; Brazelton, Thomas Berry; Choi, Anna Lai; Tolbert, Paige E.; Altshul, Larisa M.; Korrick, Susan Abigail (National Institute of Environmental Health Sciences, 2008)
      Background: Previous literature suggests an association between organochlorines and behavioral measures in childhood, including inattention. Objective: This study was designed to assess whether prenatal organochlorine ...
    • Thyroid Dysfunction as a Mediator of Organochlorine Neurotoxicity in Preschool Children 

      Julvez, Jordi; Debes, Frodi; Weihe, Pal; Choi, Anna Lai; Grandjean, Philippe (Environmental Health Perspectives, 2011)
      Background: Exposure to organochlorine compounds (OCs) can alter thyroid function in humans, and hypothyroidism during early life can adversely affect a child’s neurodevelopment. Objectives: In this study we aimed to assess ...
    • Visual evoked potentials in children prenatally exposed to methylmercury 

      Yorifuji, Takashi; Murata, Katsuyuki; Bjerve, Kristian S.; Choi, Anna Lai; Weihe, Pal; Grandjean, Philippe (Elsevier BV, 2013)
      Prenatal exposure to methylmercury can cause both neurobehavioral deficits and neurophysiological changes. However, evidence of neurotoxic effects within the visual nervous system is inconsistent, possibly due to incomplete ...
    • Which Fish Should I Eat? Perspectives Influencing Fish Consumption Choices 

      Oken, Emily; Choi, Anna Lai; Karagas, Margaret R.; Mariën, Koenraad; Rheinberger, Christoph M.; Schoeny, Rita; Sunderland, Elsie; Korrick, Susan Abigail (National Institute of Environmental Health Sciences, 2012)
      Background: Diverse perspectives have influenced fish consumption choices. Objectives: We summarized the issue of fish consumption choice from toxicological, nutritional, ecological, and economic points of view; identified ...