Browsing by Author "Nielsen, Gunnlaugur"

Now showing items 1-4 of 4

    • Genotyping Cancer-Associated Genes in Chordoma Identifies Mutations in Oncogenes and Areas of Chromosomal Loss Involving CDKN2A, PTEN, and SMARCB1 

      Choy, Edwin; MacConaill, Laura E.; Cote, Gregory M.; Le, Long P.; Shen, Jacson K.; Nielsen, Gunnlaugur P.; Iafrate, Anthony J.; Garraway, Levi A.; Hornicek, Francis J.; Duan, Zhenfeng (Public Library of Science, 2014)
      The molecular mechanisms underlying chordoma pathogenesis are unknown. We therefore sought to identify novel mutations to better understand chordoma biology and to potentially identify therapeutic targets. Given the ...

    • Integrative genomic analyses of neurofibromatosis tumours identify SOX9 as a biomarker and survival gene 

      Miller, Shyra J; Jessen, Walter J; Mehta, Tapan; Hardiman, Atira; Sites, Emily; Kaiser, Sergio; Jegga, Anil G; Upadhyaya, Meena; Giovannini, Marco; Wallace, Margaret R; Lopez, Eva; Serra, Eduard; Lazaro, Conxi; Page, Grier; Aronow, Bruce J; Ratner, Nancy; Li, Hua; Muir, David; Nielsen, Gunnlaugur Petur; Stemmer-Rachamimov, Anat (WILEY-VCH Verlag, 2009)
      Understanding the biological pathways critical for common neurofibromatosis type 1 (NF1) peripheral nerve tumours is essential, as there is a lack of tumour biomarkers, prognostic factors and therapeutics. We used gene ...

    • Intraosseous Synovial Sarcoma of the Proximal Tibia 

      Beck, Sarah E.; Nielsen, Gunnlaugur Petur; Raskin, Kevin Andrew; Schwab, Joseph H. (Hindawi Publishing Corporation, 2011)
      Synovial Sarcoma is a malignant mesenchymal tumor that comprises 5–10% of all soft tissue sarcomas. The mean age of onset is thirty years old. Intraosseous presentation is very rare and has only been documented a few times. ...

    • Recurrent Chromosomal Copy Number Alterations in Sporadic Chordomas 

      Le, Long Phi; Nielsen, Gunnlaugur Petur; Rosenberg, Andrew Eric; Thomas, Dafydd; Batten, Julie M.; Deshpande, Vikram; Schwab, Joseph H; Duan, Zhenfeng; Xavier, Ramnik; Hornicek, Francis John; Iafrate, Anthony John (Public Library of Science, 2011)
      The molecular events in chordoma pathogenesis have not been fully delineated, particularly with respect to copy number changes. Understanding copy number alterations in chordoma may reveal critical disease mechanisms that ...