Now showing items 1-20 of 29

    • Born Normalization for Fluorescence Optical Projection Tomography for Whole Heart Imaging 

      Vinegoni, Claudio; Razansky, Daniel; Figueiredo, Jose-Luiz; Fexon, Lyuba; Pivovarov, Misha; Nahrendorf, Matthias; Ntziachristos, Vasilis; Weissleder, Ralph (MyJove Corporation, 2009)
      Optical projection tomography is a three-dimensional imaging technique that has been recently introduced as an imaging tool primarily in developmental biology and gene expression studies. The technique renders biological ...
    • Chronic variable stress activates hematopoietic stem cells 

      Heidt, Timo; Sager, Hendrik B.; Courties, Gabriel; Dutta, Partha; Iwamoto, Yoshiko; Zaltsman, Alex; von zur Muhlen, Constantin; Bode, Christoph; Fricchione, Gregory L.; Denninger, John; Lin, Charles P.; Vinegoni, Claudio; Libby, Peter; Swirski, Filip K.; Weissleder, Ralph; Nahrendorf, Matthias (2014)
      Exposure to psychosocial stress is a risk factor for many diseases, including atherosclerosis1,2. While incompletely understood, interaction between the psyche and the immune system provides one potential mechanism linking ...
    • Complete genome of Staphylococcus aureus Tager 104 provides evidence of its relation to modern systemic hospital-acquired strains 

      Davis, Richard W.; Brannen, Andrew D.; Hossain, Mohammad J.; Monsma, Scott; Bock, Paul E.; Nahrendorf, Matthias; Mead, David; Lodes, Michael; Liles, Mark R.; Panizzi, Peter (BioMed Central, 2016)
      Background: Staphylococcus aureus (S. aureus) infections range in severity due to expression of certain virulence factors encoded on mobile genetic elements (MGE). As such, characterization of these MGE, as well as single ...
    • Direct Imaging of Cerebral Thromboemboli Using Computed Tomography and Fibrin-targeted Gold Nanoparticles 

      Kim, Jeong-Yeon; Ryu, Ju Hee; Schellingerhout, Dawid; Sun, In-Cheol; Lee, Su-Kyoung; Jeon, Sangmin; Kim, Jiwon; Kwon, Ick Chan; Nahrendorf, Matthias; Ahn, Cheol-Hee; Kim, Kwangmeyung; Kim, Dong-Eog (Ivyspring International Publisher, 2015)
      Computed tomography (CT) is the current standard for time-critical decision-making in stroke patients, informing decisions on thrombolytic therapy with tissue plasminogen activator (tPA), which has a narrow therapeutic ...
    • Direct Thrombus Imaging in Stroke 

      Kim, Jongseong; Park, Jung E.; Nahrendorf, Matthias; Kim, Dong-Eog (Korean Stroke Society, 2016)
      There is an emergent need for imaging methods to better triage patients with acute stroke for tissue-plasminogen activator (tPA)-mediated thrombolysis or endovascular clot retrieval by directly visualizing the size and ...
    • Does FXIII Deficiency Impair Wound Healing after Myocardial Infarction? 

      Nahrendorf, Matthias; Weissleder, Ralph; Ertl, Georg (Public Library of Science, 2006)
      Inadequate healing of myocardial infarction may contribute to local expansion of the infarct, frequently leading to chamber dilation, heart failure, or myocardial rupture. Experimental evidence in mouse models suggests ...
    • Flow Perturbation Mediates Neutrophil Recruitment and Potentiates Endothelial Injury via TLR2 in MiceNovelty and Significance 

      Franck, Grégory; Mawson, Thomas L.; Sausen, Grasiele; Salinas, Manuel; Masson, Gustavo Santos; Cole, Andrew James; Beltrami-Moreira, Marina; Chatzizisis, Yiannis; Quillard, Thibault; Tesmenitsky, Yevgenia; Shvartz, Eugenia; Sukhova, Galina K.; Swirski, Filip K.; Nahrendorf, Matthias; Aikawa, Elena; Croce, Kevin James; Libby, Peter (Ovid Technologies (Wolters Kluwer Health), 2017)
    • Imaging of the unstable plaque: how far have we got? 

      Matter, Christian M.; Stuber, Matthias; Nahrendorf, Matthias (Oxford University Press, 2009)
      Rupture of unstable plaques may lead to myocardial infarction or stroke and is the leading cause of morbidity and mortality in western countries. Thus, there is a clear need for identifying these vulnerable plaques before ...
    • IRF3 and type I interferons fuel a fatal response to myocardial infarction 

      King, Kevin R; Aguirre, Aaron Dominic; Ye, Yu-Xiang; Sun, Yuan; Roh, Jason David; Ng, Richard Patrick; Kohler, Rainer H.; Arlauckas, Sean Philip; Iwamoto, Yoshiko; Savol, Andrej J; Sadreyev, Ruslan; Kelly, Mark; Fitzgibbons, Timothy P; Fitzgerald, Katherine A; Mitchison, Timothy J.; Libby, Peter; Nahrendorf, Matthias; Weissleder, Ralph (Springer Nature, 2017)
      Interferon regulatory factor 3 (IRF3) and type I interferons (IFNs) protect against infections and cancer, but excessive IRF3 activation and type I IFN production cause autoinflammatory conditions such as Aicardi–Goutières ...
    • Late Na+ current and protracted electrical recovery are critical determinants of the aging myopathy 

      Signore, Sergio; Sorrentino, Andrea; Borghetti, Giulia; Cannata, Antonio; Meo, Marianna; Zhou, Yu; Kannappan, Ramaswamy; Pasqualini, Francesco; O'Malley, Heather; Sundman, Mark; Tsigkas, Nikolaos; Zhang, Eric; Arranto, Christian; Mangiaracina, Chiara; Isobe, Kazuya; Sena, Brena F.; Kim, Junghyun; Goichberg, Polina; Nahrendorf, Matthias; Isom, Lori L.; Leri, Annarosa; Anversa, Piero; Rota, Marcello (Nature Pub. Group, 2015)
      The aging myopathy manifests itself with diastolic dysfunction and preserved ejection fraction. We raised the possibility that, in a mouse model of physiological aging, defects in electromechanical properties of cardiomyocytes ...
    • Leukocytes Link Local and Systemic Inflammation in Ischemic Cardiovascular Disease 

      Libby, Peter; Nahrendorf, Matthias; Swirski, Filip K. (Elsevier BV, 2016)
      Physicians have traditionally viewed ischemic heart disease in a cardiocentric manner: plaques grow in arteries until they block blood flow, causing acute coronary and other ischemic syndromes. Recent research provides new ...
    • Local proliferation dominates lesional macrophage accumulation in atherosclerosis 

      Robbins, Clinton S.; Hilgendorf, Ingo; Weber, Georg F.; Theurl, Igor; Iwamoto, Yoshiko; Figueiredo, Jose-Luiz; Gorbatov, Rostic; Sukhova, Galina K.; Gerhardt, Louisa M.S.; Smyth, David; Zavitz, Caleb C. J.; Shikatani, Eric A.; Parsons, Michael; van Rooijen, Nico; Lin, Herbert Y.; Husain, Mansoor; Libby, Peter; Nahrendorf, Matthias; Weissleder, Ralph; Swirski, Filip K. (2013)
      During the inflammatory response that drives atherogenesis, macrophages accumulate progressively in the expanding arterial wall1,2. The observation that circulating monocytes give rise to lesional macrophages3–9 has ...
    • Lp-PLA 2 Antagonizes Left Ventricular Healing After Myocardial Infarction by Impairing the Appearance of Reparative MacrophagesCLINICAL PERSPECTIVE 

      He, Shun; Chousterman, Benjamin; Fenn, Ashley Margaret; Anzai, Atsushi; Nairz, Manfred; Brandt, Martin; Hilgendorf, Ingo; Sun, Yuan; Ye, Yu-Xiang; Iwamoto, Yoshiko; Tricot, Benoit; Weissleder, Ralph; Macphee, Colin; Libby, Peter; Nahrendorf, Matthias; Swirski, Filip K. (Ovid Technologies (Wolters Kluwer Health), 2015)
      Background—Healing after myocardial infarction (MI) involves the biphasic accumulation of inflammatory Ly-6Chigh and reparative Ly-6Clow monocytes/macrophages. Excessive inflammation disrupts the balance between the 2 ...
    • Lp-PLA2 Antagonizes Left Ventricular Healing After Myocardial Infarction by Impairing the Appearance of Reparative Macrophages 

      He, Shun; Chousterman, Benjamin G.; Fenn, Ashley; Anzai, Atsushi; Nairz, Manfred; Brandt, Martin; Hilgendorf, Ingo; Sun, Yuan; Ye, Yu-Xiang; Iwamoto, Yoshiko; Tricot, Benoit; Weissleder, Ralph; Macphee, Colin; Libby, Peter; Nahrendorf, Matthias; Swirski, Filip K. (Lippincott Williams & Wilkins, 2015)
      Background— Healing after myocardial infarction (MI) involves the biphasic accumulation of inflammatory Ly-6Chigh and reparative Ly-6Clow monocytes/macrophages. Excessive inflammation disrupts the balance between the 2 ...
    • Macrophages retain hematopoietic stem cells in the spleen via VCAM-1 

      Dutta, Partha; Hoyer, Friedrich Felix; Grigoryeva, Lubov S.; Sager, Hendrik B.; Leuschner, Florian; Courties, Gabriel; Borodovsky, Anna; Novobrantseva, Tatiana; Ruda, Vera M.; Fitzgerald, Kevin; Iwamoto, Yoshiko; Wojtkiewicz, Gregory; Sun, Yuan; Da Silva, Nicolas; Libby, Peter; Anderson, Daniel G.; Swirski, Filip K.; Weissleder, Ralph; Nahrendorf, Matthias (The Rockefeller University Press, 2015)
      Splenic myelopoiesis provides a steady flow of leukocytes to inflamed tissues, and leukocytosis correlates with cardiovascular mortality. Yet regulation of hematopoietic stem cell (HSC) activity in the spleen is incompletely ...
    • Mapping Molecular Agents Distributions in Whole Mice Hearts Using Born-Normalized Optical Projection Tomography 

      Vinegoni, Claudio; Feruglio, Paolo Fumene; Razansky, Daniel; Gorbatov, Rostic; Ntziachristos, Vasilis; Sbarbati, Andrea; Nahrendorf, Matthias; Weissleder, Ralph (Public Library of Science, 2012)
      To date there is a lack of tools to map the spatio-temporal dynamics of diverse cells in experimental heart models. Conventional histology is labor intensive with limited coverage, whereas many imaging techniques do not ...
    • Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction 

      Zangi, Lior; Lui, Kathy O; von Gise, Alexander; Ma, Qing; Ebina, Wataru; Ptaszek, Leon M.; Später, Daniela; Xu, Huansheng; Tabebordbar, Mohammadsharif; Gorbatov, Rostic; Sena, Brena; Nahrendorf, Matthias; Briscoe, David Michael; Li, Ronald A; Wagers, Amy Jo; Rossi, Derrick J; Pu, William T.; Chien, Kenneth R (Nature Publishing Group, 2013)
      In a cell-free approach to regenerative therapeutics, transient application of paracrine factors in vivo could be used to alter the behavior and fate of progenitor cells to achieve sustained clinical benefits. Here we show ...
    • Molecularly Self-Assembled Nucleic Acid Nanoparticles for Targeted In Vivo siRNA Delivery 

      Lee, Hyukjin; Lytton-Jean, Abigail K. R.; Chen, Yi; Love, Kevin T.; Park, Angela I.; Karagiannis, Emmanouil D.; Sehgal, Alfica; Querbes, William; Zurenko, Christopher S.; Jayaraman, Muthusamy; Peng, Chang G.; Charisse, Klaus; Borodovsky, Anna; Manoharan, Muthiah; Donahoe, Jessica S.; Truelove, Jessica; Nahrendorf, Matthias; Langer, Robert; Anderson, Daniel G. (2013)
      Nanoparticles are employed for delivering therapeutics into cells1,2. However, size, shape, surface chemistry and the presentation of targeting ligands on the surface of nanoparticles can affect circulation half-life and ...
    • Monocyte Subset Dynamics in Human Atherosclerosis Can Be Profiled with Magnetic Nano-Sensors 

      Wildgruber, Moritz; Chudnovskiy, Aleksey; Yoon, Tae-Jong; Etzrodt, Martin; Lee, Hakho; Pittet, Mikael J.; Nahrendorf, Matthias; Croce, Kevin James; Libby, Peter; Weissleder, Ralph; Swirski, Filip K. (Public Library of Science, 2009)
      Monocytes are circulating macrophage and dendritic cell precursors that populate healthy and diseased tissue. In humans, monocytes consist of at least two subsets whose proportions in the blood fluctuate in response to ...
    • Myocardial Infarction Accelerates Atherosclerosis 

      Leuschner, Florian; Robbins, Clinton; Iwamoto, Yoshiko; Thompson, Brian; Carlson, Alicia L.; Heidt, Timo; Lasitschka, Felix; Etzrodt, Martin; Waterman, Peter; Waring, Michael T.; Chicoine, Adam T.; van der Laan, Anja M.; Niessen, Hans W.M.; Piek, Jan J.; Rubin, Barry B.; Butany, Jagdish; Katus, Hugo A.; Murphy, Sabina A.; Pittet, Mikael J.; Lin, Charles P.; Dutta, Partha; Courties, Gabriel P; Wei, Ying; Gorbatov, Rostic; Majmudar, Maulik D; Stone, James Robert; Morrow, David Andrew; Sabatine, Marc Steven; Vinegoni, Claudio; Moskowitz, Michael Arthur; Libby, Peter; Swirski, Filip K.; Weissleder, Ralph; Nahrendorf, Matthias (Nature Publishing Group, 2012)
      During progression of atherosclerosis, myeloid cells destabilize lipid-rich plaque in the arterial wall and cause its rupture, thus triggering myocardial infarction and stroke. Survivors of acute coronary syndromes have a ...