Now showing items 1-8 of 8

    • The CCR6/CCL20 Axis Mediates Th17 Cell Migration to the Ocular Surface in Dry Eye Disease 

      Dohlman, Thomas H.; Chauhan, Sunil Kumar; Kodati, Shilpa; Hua, Jing; Chen, Yihe; Omoto, Masahiro; Sadrai, Zahra; Dana, Reza (Association for Research in Vision and Ophthalmology (ARVO), 2013)
      Purpose. Th17 cells are believed to be the primary effector cells in the pathogenesis of dry eye disease (DED). However, the mechanisms by which Th17 cells migrate from the lymphoid tissues to the ocular surface are ...
    • CCR7 Is Critical for the Induction and Maintenance of Th17 Immunity in Dry Eye Disease 

      Kodati, Shilpa; Chauhan, Sunil Kumar; Chen, Yihe; Dohlman, Thomas H.; Karimian, Parisa; Saban, Daniel; Dana, Reza (Association for Research in Vision and Ophthalmology (ARVO), 2014)
      Purpose. We characterized antigen-presenting cell (APC)–relevant chemokine receptor expression in dry eye disease (DED), and investigated the effect of topical CC chemokine receptor (CCR)-7 blockade specifically on Th17 ...
    • Chronic Dry Eye Disease is Principally Mediated by Effector Memory Th17 Cells 

      Chen, Yihe; Chauhan, Sunil K.; Lee, Hyun Soo; Saban, Daniel R.; Dana, Reza (2013)
      Recent experimental and clinical data suggest that there is a link between dry eye disease (DED) and T cell-mediated immunity. However, whether these immune responses are a consequence or cause of ocular surface inflammation ...
    • Effect of Desiccating Environmental Stress Versus Systemic Muscarinic AChR Blockade on Dry Eye Immunopathogenesis 

      Chen, Yihe; Chauhan, Sunil Kumar; Lee, Hyun Soo; Stevenson, William; Schaumburg, Chris S.; Sadrai, Zahra; Saban, Daniel R.; Kodati, Shilpa; Stern, Michael E.; Dana, Reza (Association for Research in Vision and Ophthalmology (ARVO), 2013)
      Purpose. A majority of experimental data on dry eye disease (DED) immunopathogenesis have been derived from a murine model of DED that combines desiccating environmental stress with systemic muscarinic acetylcholine ...
    • In Vivo Expansion of Regulatory T Cells by Low-Dose Interleukin-2 Treatment Increases Allograft Survival in Corneal Transplantation 

      Tahvildari, Maryam; Omoto, Masahiro; Chen, Yihe; Emami-Naeini, Parisa; Inomata, Takenori; Dohlman, Thomas H.; Kaye, Abigail E.; Chauhan, Sunil Kumar; Dana, Reza (Ovid Technologies (Wolters Kluwer Health), 2016)
      Background Corneal allograft survival dramatically decreases in hosts with inflamed or vascularized recipient beds. We have previously shown that in rejected corneal allografts regulatory T cells (Tregs) demonstrate ...
    • Ocular surface immunity: Homeostatic mechanisms and their disruption in dry eye disease 

      Barabino, Stefano; Chen, Yihe; Chauhan, Sunil Kumar; Dana, Reza (Elsevier BV, 2012)
      The tear film, lacrimal glands, corneal and conjunctival epithelia and Meibomian glands work together as a lacrimal functional unit (LFU) to preserve the integrity and function of the ocular surface. The integrity of this ...
    • PDE4 Inhibition Suppresses IL-17–Associated Immunity in Dry Eye Disease 

      Sadrai, Zahra; Stevenson, William; Okanobo, Andre; Chen, Yihe; Dohlman, Thomas H.; Hua, Jing; Amparo, Francisco; Chauhan, Sunil Kumar; Dana, Reza (Association for Research in Vision and Ophthalmology (ARVO), 2012)
      Purpose. To determine the effect of phosphodiesterase type-4 (PDE4) inhibition on IL-17–associated immunity in experimental dry eye disease (DED). Methods. Murine DED was induced, after which a PDE4 inhibitor ...
    • The Resolvin D1 Analogue Controls Maturation of Dendritic Cells and Suppresses Alloimmunity in Corneal Transplantation 

      Hua, Jing; Jin, Yiping; Chen, Yihe; Inomata, Takenori; Lee, HyunSoo; Chauhan, Sunil Kumar; Petasis, Nicos A.; Serhan, Charles Nicholas; Dana, Reza (Association for Research in Vision and Ophthalmology (ARVO), 2014)
      Purpose. To analyze the effect of a resolvin D1 (RvD1) analogue (RvD1a) on dendritic cell maturation, T-cell sensitization, and allograft rejection in corneal allotransplantation. Methods. The receptor expression ...