Now showing items 1-6 of 6

    • Eosinophil Secretion of Granule-Derived Cytokines 

      Spencer, Lisa A.; Bonjour, Kennedy; Melo, Rossana C. N.; Weller, Peter F. (Frontiers Media S.A., 2014)
      Eosinophils are tissue-dwelling leukocytes, present in the thymus, and gastrointestinal and genitourinary tracts of healthy individuals at baseline, and recruited, often in large numbers, to allergic inflammatory foci and ...
    • Eosinophils and Th2 immunity: contemporary insights 

      Spencer, Lisa Ann; Weller, Peter Fahey (Nature Publishing Group, 2010)
      Eosinophils, innate immune leukocytes elicited by Th2 cells, have long been associated with the effector arm of Th2 immune responses. However, accumulating data over the past decade reveal a much more dynamic picture of ...
    • A Gel-Based Dual Antibody Capture and Detection Method for Assaying of Extracellular Cytokine Secretion: EliCell 

      Spencer, Lisa Ann; Melo, Rossana; Perez, Sandra A. C.; Weller, Peter Fahey (2005)
      A distinguishing feature of eosinophils is their ability to rapidly release preformed cytokines from intracellular pools. Cytokines are delivered to the cell surface from granule stores by transport vesicles and are released ...
    • Subcellular fractionation of human eosinophils: Isolation of functional specific granules on isoosmotic density gradients 

      Neves, Josiane S.; Perez, Sandra A.C.; Spencer, Lisa Ann; Melo, Rossana; Weller, Peter Fahey (Elsevier BV, 2009)
      Subcellular fractionation has been an important tool in investigating human eosinophil structure and function, including localizing of cytokine/chemokines within granules, investigating granule protein translocation and ...
    • The transcription factor XBP1 is selectively required for eosinophil differentiation 

      Bettigole, Sarah Elizabeth; Lis, Raphael; Adoro, Stanley; Lee, Ann-Hwee; Spencer, Lisa Ann; Weller, Peter Fahey; Glimcher, Laurie Hollis (Nature Publishing Group, 2015)
      The transcription factor XBP1 has been linked to the development of highly secretory tissues such as plasma cells and Paneth cells, yet its function in granulocyte maturation has remained unknown. Here we discovered an ...
    • Vesicle-mediated secretion of human eosinophil granule-derived major basic protein 

      Melo, Rossana; Spencer, Lisa Ann; Perez, Sandra A C; Neves, Josiane S; Bafford, Staci P; Morgan, Ellen S; Dvorak, Ann Marie; Weller, Peter Fahey (Nature Publishing Group, 2009)
      Major basic protein (MBP), the predominant cationic protein of human eosinophil specific granules, is stored within crystalloid cores of these granules. Secretion of MBP contributes to the immunopathogenesis of varied ...