Now showing items 1-4 of 4

    • The Differentiation and Stress Response Factor XBP-1 Drives Multiple Myeloma Pathogenesis 

      Carrasco, Daniel R.; Sukhdeo, Kumar; Protopopova, Marina; Enos, Miriam; Zheng, Mei; Mani, Mala; Ivanova, Elena V.; Tonon, Giovanni; Sinha, Raktim; Carrasco, Daniel E.; Henderson, Joel Michael; Pinkus, Geraldine Sowinski; Munshi, Nikhil C; Horner, James W.; Protopopov, Alexei; Anderson, Kenneth Carl; DePinho, Ronald A. (Cell Press, 2007)
      Multiple myeloma (MM) evolves from a highly prevalent premalignant condition termed MGUS. The factors underlying the malignant transformation of MGUS are unknown. We report a MGUS/MM phenotype in transgenic mice with ...
    • Feedback Circuit among INK4 Tumor Suppressors Constrains Human Glioblastoma Development 

      Wiedemeyer, Ruprecht; Brennan, Cameron; Heffernan, Timothy P.; Xiao, Yonghong; Mahoney, John T.; Protopopov, Alexei; Zheng, Hongwu; Bignell, Graham; Furnari, Frank; Cavenee, Webster K.; Hahn, William C.; Ichimura, Koichi; Collins, Peter V.; Chu, Gerald C.; Stratton, Michael R.; Ligon, Keith Lloyd; Futreal, Andrew P.; Chin, Lynda (Cell Press, 2008)
      We have developed a nonheuristic genome topography scan (GTS) algorithm to characterize the patterns of genomic alterations in human glioblastoma (GBM), identifying frequent p18^{INK4C} and p16^{INK4A} codeletion. Functional ...
    • Oncogenesis of T-ALL and Nonmalignant Consequences of Overexpressing Intracellular NOTCH1 

      Li, Xiaoyu; Gounari, Fotini; Protopopov, Alexei; Khazaie, Khashayarsha; von Boehmer, Harald (Rockefeller University Press, 2008)
      Mutations resulting in overexpression of intracellular Notch1 (ICN1) are frequently observed in human T cell acute lymphoblastic leukemia (T-ALL). We have determined the consequences of ICN1 overexpression from retroviral ...
    • Telomerase Inhibition by siRNA Causes Senescence and Apoptosis in Barrett's Adenocarcinoma Cells: Mechanism and Therapeutic Potential 

      Shammas, Masood A.; Koley, Hemanta; Batchu, Ramesh B.; Bertheau, Robert C.; Protopopov, Alexei; Munshi, Nikhil C; Goyal, Raj K. (BioMed Central, 2005)
      Background: In cancer cells, telomerase induction helps maintain telomere length and thereby bypasses senescence and provides enhanced replicative potential. Chemical inhibitors of telomerase have been shown to reactivate ...