Now showing items 1-6 of 6

    • Immunomodulation by Mesenchymal Stem Cells A Potential Therapeutic Strategy for Type 1 Diabetes 

      Abdi, Reza; Fiorina, Paolo; Adra, Chaker N.; Atkinson, Mark; Sayegh, Mohamed Hassan (American Diabetes Association, 2008)
      Mesenchymal stem cells (MSCs) are pluripotent stromal cells that have the potential to give rise to cells of diverse lineages. Interestingly, MSCs can be found in virtually all postnatal tissues. The main criteria currently ...
    • Immunosuppressive Activity of Size-Controlled PEG-PLGA Nanoparticles Containing Encapsulated Cyclosporine A 

      Kwon, Mincheol; Fan, Timothy M.; Cheng, Jianjun; Tang, Li; Azzi, Jamil; Mounayar, Marwan; Yin, Qian; Moore, Robert; Skartsis, Nikolaos; Abdi, Reza; Tong, Rong (Hindawi Publishing Corporation, 2012)
      We encapsulated cyclosporine A (CsA) in poly(ethylene glycol)-b-poly(d,l-lactide-co-glycolide) (PEG-PLGA) nanoparticles (NPs) by nanoprecipitation of CsA and PEG-PLGA. The resulting CsA/PEG-PLGA-NPs were <100 nm in diameter ...
    • Live Images of Donor Dendritic Cells Trafficking via CX3CR1 Pathway 

      Ueno, Takuya; Kim, Pilhan; McGrath, Martina M.; Yeung, Melissa Y.; Shimizu, Tetsunosuke; Jung, Keehoon; Sayegh, Mohamed H.; Chandraker, Anil K.; Abdi, Reza; Yun, Seok H. (Frontiers Media S.A., 2016)
      Background: A number of studies have demonstrated the role of CX3CR1 in regulating the migration of monocytes into peripheral tissue and their transformation into dendritic cell (DC). No data are yet available on the ...
    • The Novel Therapeutic Effect of Phosphoinositide 3-Kinase-γ Inhibitor AS605240 in Autoimmune Diabetes 

      Azzi, Jamil; Moore, Robert F.; Elyaman, Wassim; Mounayar, Marwan; El Haddad, Najib; Yang, Sunmi; Jurewicz, Mollie; Takakura, Ayumi; Petrelli, Alessandra; Fiorina, Paolo; Ruckle, Thomas; Abdi, Reza (American Diabetes Association, 2012)
      Type 1 diabetes (T1D) remains a major health problem worldwide, with a steadily rising incidence yet no cure. Phosphoinositide 3-kinase-γ (PI3Kγ), a member of a family of lipid kinases expressed primarily in leukocytes, ...
    • PI3Kγ Deficient NOD-Mice Are Protected from Diabetes by Restoring the Balance of Regulatory to Effector-T-Cells 

      Azzi, Jamil; Thueson, Lindsay; Moore, Robert; Abdoli, Rozita; Reijonen, Helena; Abdi, Reza (Public Library of Science, 2017)
      With a steady increase in its incidence and lack of curative treatment, type 1 diabetes (T1D) has emerged as a major health problem worldwide. To design novel effective therapies, there is a pressing need to identify ...
    • Targeting CD22 Reprograms B-Cells and Reverses Autoimmune Diabetes 

      Dada, Shirine; Wong, Masie; Law, Kenneth; Wu, Erxi; Dunussi-Joannopoulos, Kyri; Bluestone, Jeffrey; Fiorina, Paolo; Vergani, Andrea; Jurewicz, Mollie; Tian, Ze; Abdi, Reza; Guleria, Indira; Rodig, Scott J.; Sayegh, Mohamed Hassan (American Diabetes Association, 2008)
      OBJECTIVES—To investigate a B-cell–depleting strategy to reverse diabetes in naïve NOD mice. RESEARCH DESIGN AND METHODS—We targeted the CD22 receptor on B-cells of naïve NOD mice to deplete and reprogram B-cells to ...