Now showing items 1-5 of 5

    • The Behaviour of 5-Hydroxymethylcytosine in Bisulfite Sequencing 

      Huang, Yun; Pastor, William Abraham; Shen, Yinghua; Tahiliani, Mamta V.; Liu, David Ruchien; Rao, Anjana; Liu, Jun (Public Library of Science, 2010)
      Background: We recently showed that enzymes of the TET family convert 5-mC to 5-hydroxymethylcytosine (5-hmC) in DNA. 5-hmC is present at high levels in embryonic stem cells and Purkinje neurons. The methylation status of ...
    • Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by the MLL Partner TET1 

      Tahiliani, Mamta V.; Koh, Kian Peng; Shen, Yinghua; Pastor, William Abraham; Bandukwala, Hozefa S; Brudno, Yevgeny; Agarwal, Suneet; Iyer, Lakshminarayan M.; Liu, David Ruchien; Aravind, L; Rao, Anjana (American Association for the Advancement of Science, 2009)
      DNA cytosine methylation is crucial for retrotransposon silencing and mammalian development. In a computational search for enzymes that could modify 5-methylcytosine (5mC), we identified TET proteins as mammalian homologs ...
    • Runx3 and T-box Proteins Cooperate to Establish the Transcriptional Program of Effector CTLs 

      Cruz-Guilloty, Fernando; Pipkin, Matthew E.; Djuretic, Ivana M.; Levanon, Ditsa; Lotem, Joseph; Lichtenheld, Mathias G.; Groner, Yoram; Rao, Anjana (The Rockefeller University Press, 2009)
      Activation of naive CD8+ T cells with antigen induces their differentiation into effector cytolytic T lymphocytes (CTLs). CTLs lyse infected or aberrant target cells by exocytosis of lytic granules containing the pore-forming ...
    • The Transcription Factor NFAT5 Is Required for Cyclin Expression and Cell Cycle Progression in Cells Exposed to Hypertonic Stress 

      Drews-Elger, Katherine; Ortells, M. Carmen; Rao, Anjana; López-Rodriguez, Cristina; Aramburu, Jose (Public Library of Science, 2009)
      Background: Hypertonicity can perturb cellular functions, induce DNA damage-like responses and inhibit proliferation. The transcription factor NFAT5 induces osmoprotective gene products that allow cells to adapt to sustained ...
    • Transcriptional Complexes Formed by NFAT Dimers Regulate the Induction of T Cell Tolerance 

      Soto-Nieves, Noemi; Puga, Irene; Abe, Brian T.; Bandyopadhyay, Sanmay; Baine, Ian; Rao, Anjana; Macian, Fernando (The Rockefeller University Press, 2009)
      In T cells, anergy can be induced after T cell receptor engagement in the absence of costimulation. Under these conditions, the expression of a specific set of anergy-associated genes is activated. Several lines of evidence ...