Browsing by Author "Madara, Joseph"

Now showing items 1-4 of 4

    • Appetite controlled by a cholecystokinin nucleus of the solitary tract to hypothalamus neurocircuit 

      D'Agostino, Giuseppe; Lyons, David J; Cristiano, Claudia; Burke, Luke K; Madara, Joseph C; Campbell, John N; Garcia, Ana Paula; Land, Benjamin B; Lowell, Bradford B; Dileone, Ralph J; Heisler, Lora K (eLife Sciences Publications, Ltd, 2016)
      The nucleus of the solitary tract (NTS) is a key gateway for meal-related signals entering the brain from the periphery. However, the chemical mediators crucial to this process have not been fully elucidated. We reveal ...

    • Excitatory transmission onto AgRP neurons is regulated by cJun NH2-terminal kinase 3 in response to metabolic stress 

      Vernia, Santiago; Morel, Caroline; Madara, Joseph C; Cavanagh-Kyros, Julie; Barrett, Tamera; Chase, Kathryn; Kennedy, Norman J; Jung, Dae Young; Kim, Jason K; Aronin, Neil; Flavell, Richard A; Lowell, Bradford B; Davis, Roger J (eLife Sciences Publications, Ltd, 2016)
      The cJun NH2-terminal kinase (JNK) signaling pathway is implicated in the response to metabolic stress. Indeed, it is established that the ubiquitously expressed JNK1 and JNK2 isoforms regulate energy expenditure and insulin ...

    • A neural basis for melanocortin-4 receptor regulated appetite 

      Garfield, Alastair S.; Li, Chia; Madara, Joseph C.; Shah, Bhavik P.; Webber, Emily; Steger, Jennifer S.; Campbell, John N.; Gavrilova, Oksana; Lee, Charlotte E.; Olson, David P.; Elmquist, Joel K.; Tannous, Bakhos A.; Krashes, Michael J.; Lowell, Bradford B. (2015)
      Pro-opiomelanocortin (POMC)- and agouti-related peptide (AgRP)-expressing neurons are oppositely regulated by caloric depletion and co-ordinately stimulate and inhibit homeostatic satiety, respectively. This bimodality is ...

    • A Novel Excitatory Paraventricular Nucleus to AgRP Neuron Circuit that Drives Hunger 

      Krashes, Michael J.; Shah, Bhavik P.; Madara, Joseph C.; Olson, David P.; Strochlic, David E.; Garfield, Alastair S.; Vong, Linh; Pei, Hongjuan; Watabe-Uchida, Mitsuko; Uchida, Naoshige; Liberles, Stephen D.; Lowel, Bradford B. (2014)
      Summary Hunger is a hard-wired motivational state essential for survival. Agouti-related peptide (AgRP)-expressing neurons in the arcuate nucleus (ARC) at the base of the hypothalamus are crucial to its control. They are ...