Browsing by Author "Douda, David N."

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Aspirin-triggered resolvin D1 is produced during self-resolving gram-negative bacterial pneumonia and regulates host immune responses for the resolution of lung inflammation

Abdulnour, Raja Elie E.; Sham, Ho Pan; Douda, David N.; Colas, Romain A.; Dalli, Jesmond; Bai, Yan; Ai, Xingbin; Serhan, Charles N.; Levy, Bruce D. (2016)

Bacterial pneumonia is a leading cause of morbidity and mortality worldwide. Host responses to contain infection and mitigate pathogen-mediated lung inflammation are critical for pneumonia resolution. Aspirin-triggered ...
Effect of Arginase Inhibition on Pulmonary L-Arginine Metabolism in Murine Pseudomonas Pneumonia

Mehl, Anne; Ghorbani, Peyman; Douda, David; Huang, Hailu; Palaniyar, Nades; Ratjen, Felix; Grasemann, Hartmut (Public Library of Science, 2014)

Rationale: Infection of the lung with Pseudomonas aeruginosa results in upregulation of nitric oxide synthases (NOS) and arginase expression, and both enzymes compete for L-arginine as substrate. Nitric oxide (NO) production ...
A Lipid Mediator Hepoxilin A3 Is a Natural Inducer of Neutrophil Extracellular Traps in Human Neutrophils

Douda, David N.; Grasemann, Hartmut; Pace-Asciak, Cecil; Palaniyar, Nades (Hindawi Publishing Corporation, 2015)

Pulmonary exacerbations in cystic fibrosis airways are accompanied by inflammation, neutrophilia, and mucous thickening. Cystic fibrosis sputum contains a large amount of uncleared DNA contributed by neutrophil extracellular ...