Now showing items 1-3 of 3

    • Mammalian E-type Cyclins Control Chromosome Pairing, Telomere Stability and CDK2 Localization in Male Meiosis 

      Martinerie, Laetitia; Manterola, Marcia; Chung, Sanny S. W.; Panigrahi, Sunil K.; Weisbach, Melissa; Vasileva, Ana; Geng, Yan; Sicinski, Peter; Wolgemuth, Debra J. (Public Library of Science, 2014)
      Loss of function of cyclin E1 or E2, important regulators of the mitotic cell cycle, yields viable mice, but E2-deficient males display reduced fertility. To elucidate the role of E-type cyclins during spermatogenesis, we ...
    • p600 Plays Essential Roles in Fetal Development 

      Nakaya, Takeo; Ishiguro, Kei-ichiro; Belzil, Camille; Rietsch, Anna M.; Yu, Qunyan; Mizuno, Shin-ichi; Bronson, Roderick T.; Geng, Yan; Nguyen, Minh Dang; Akashi, Koichi; Sicinski, Piotr; Nakatani, Yoshihiro (Public Library of Science, 2013)
      p600 is a multifunctional protein implicated in cytoskeletal organization, integrin-mediated survival signaling, calcium-calmodulin signaling and the N-end rule pathway of ubiquitin-proteasome-mediated proteolysis. While ...
    • Proteomic Landscape of Tissue-Specific Cyclin E Functions in Vivo 

      Odajima, Junko; Saini, Siddharth; Jung, Piotr; Ndassa-Colday, Yasmine; Ficaro, Scott; Geng, Yan; Marco, Eugenio; Michowski, Wojciech; Wang, Yaoyu E.; DeCaprio, James A.; Litovchick, Larisa; Marto, Jarrod; Sicinski, Piotr (Public Library of Science, 2016)
      E-type cyclins (cyclins E1 and E2) are components of the cell cycle machinery that has been conserved from yeast to humans. The major function of E-type cyclins is to drive cell division. It is unknown whether in addition ...