Browsing by Author "Hogle, James"
Now showing items 1-10 of 10
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Biometric Navigation with Ultrasound
Schwartz, Benjamin Matthew (2013-04-16)We have designed and demonstrated a new class of medical navigation methods that use the fingerprint-like biometrically distinct ultrasound echo patterns produced by different locations in tissue. As an example of this new ... -
Capsid Protein VP4 of Human Rhinovirus Induces Membrane Permeability by the Formation of a Size-Selective Multimeric Pore
Panjwani, Anusha; Strauss, Mike; Gold, Sarah; Wenham, Hannah; Jackson, Terry; Chou, James J.; Rowlands, David J.; Stonehouse, Nicola J.; Hogle, James M.; Tuthill, Tobias J. (Public Library of Science, 2014)Non-enveloped viruses must deliver their viral genome across a cell membrane without the advantage of membrane fusion. The mechanisms used to achieve this remain poorly understood. Human rhinovirus, a frequent cause of the ... -
DNA Polymerase Exchange and Lesion Bypass in Escherichia Coli
Kath, James Evon (2015-11-13)Translesion synthesis (TLS) alleviates replication stalling at DNA lesions. Bypass of lesions by specialized translesion DNA polymerases involves exchange with high-fidelity replicative polymerases. As a consequence of ... -
Engineered Biofilms for Materials Production and Patterning
Chen, Yuyin (2016-04-22)Natural materials, such as bone, integrate living cells composed of organic molecules together with inorganic components. This enables combinations of functionalities, such as mechanical strength and the ability to regenerate ... -
Improved PET Data Quantification in Simultaneous PET/MR Neuroimaging
Chonde, Daniel B. (2015-05-16)Recently, systems that integrate positron emission tomography and magnetic resonance imaging (PET/MR) have become available for clinical use. This new technology, which combines the high spatial resolution and superior ... -
An Interaction between Glutathione and the Capsid Is Required for the Morphogenesis of C-Cluster Enteroviruses
Ma, Hsin-Chieh; Liu, Ying; Wang, Chunling; Strauss, Michael; Rehage, Nina; Chen, Ying-Han; Altan-Bonnet, Nihal; Hogle, James; Wimmer, Eckard; Mueller, Steffen; Paul, Aniko V.; Jiang, Ping (Public Library of Science, 2014)Glutathione (GSH) is the most abundant cellular thiol playing an essential role in preserving a reduced cellular environment. Cellular GSH levels can be efficiently reduced by the GSH biosynthesis inhibitor, L-buthionine ... -
Investigating Host Protein Function and Developing Assays for Influenza Virus Infection
Sun, Eileen (2015-04-08)With eight genomic segments encoding at least thirteen proteins, influenza virus can subvert a cell into a virus-producing factory. To study influenza infection, I utilize versatile fluorescent-based technologies to ... -
Nanoscale Organization and Optical Observation of Biomolecules With DNA Nanotechnology
Dai, Mingjie (2016-05-19)Understanding biomolecular information at the single-molecule level requires tools for manipulating and observing individual biomolecules at the nanoscale. Programmable DNA nanotechnology provides an ideal interface to ... -
Optogenetics and Computer Vision for C. elegans Neuroscience and Other Biophysical Applications
Leifer, Andrew (2012-07-19)This work presents optogenetics and real-time computer vision techniques to non-invasively manipulate and monitor neural activity with high spatiotemporal resolution in awake behaving Caenorhabditis elegans. These methods ... -
Predicting the Effects of Missense Variation on Protein Structure, Function, and Evolution
Jordan, Daniel Michael (2015-05-08)Estimating the effects of missense mutations is a problem with many important applications in a variety of fields, including medical genetics, evolutionary theory, population genetics, and protein structure and design. ...