Browsing by Author "Shi, Yujiang"
Now showing items 1-4 of 4
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Genome-wide comparison of DNA hydroxymethylation in mouse embryonic stem cells and neural progenitor cells by a new comparative hMeDIP-seq method
Tan, Li; Xiong, Lijun; Xu, Wenqi; Wu, Feizhen; Huang, Ning; Xu, Yufei; Kong, Lingchun; Zheng, Lijuan; Schwartz, Lisa; Shi, Yang; Shi, Yujiang (Oxford University Press, 2013)The genome-wide distribution patterns of the ‘6th base’ 5-hydroxymethylcytosine (5hmC) in many tissues and cells have recently been revealed by hydroxymethylated DNA immunoprecipitation (hMeDIP) followed by high throughput ... -
Loss of 5-hydroxymethylcytosine correlates with increasing morphologic dysplasia in melanocytic tumors
Larson, Allison R.; Dresser, Karen; Zhan, Qian; Lezcano, Cecilia; Woda, Bruce A.; Yosufi, Benafsha; Thompson, John F.; Scolyer, Richard A.; Mihm, Martin C.; Shi, Yujiang G.; Murphy, George F.; Lian, Christine Guo (2013)DNA methylation is the most well studied epigenetic modification in cancer biology. 5-hydroxymethylcytosine is an epigenetic mark that can be converted from 5-methylcytosine by the ten-eleven translocation gene family. We ... -
New Mechanisms of Activation by Histone Demethylases in Gene Regulation
Clark, Erin Amelia (2013-10-15)The epigenetic mechanisms that connect hormone signaling to chromatin remain largely unknown. Here we show that LSD1/KDM1A is a critical glucocorticoid receptor (GR) coactivator and report a previously unexplored mechanism ... -
A primary role of TET proteins in establishment and maintenance of De Novo bivalency at CpG islands
Kong, Lingchun; Tan, Li; Lv, Ruitu; Shi, Zhennan; Xiong, Lijun; Wu, Feizhen; Rabidou, Kimberlie; Smith, Michael; He, Celestine; Zhang, Lei; Qian, Yanyan; Ma, Duan; Lan, Fei; Shi, Yang; Shi, Yujiang Geno (Oxford University Press, 2016)Ten Eleven Translocation (TET) protein-catalyzed 5mC oxidation not only creates novel DNA modifications, such as 5hmC, but also initiates active or passive DNA demethylation. TETs’ role in the crosstalk with specific histone ...