Now showing items 1-7 of 7

    • Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels 

      Chauhan, Vikash P.; Martin, John D.; Liu, Hao; Lacorre, Delphine A.; Jain, Saloni R.; Kozin, Sergey V.; Stylianopoulos, Triantafyllos; Mousa, Ahmed S.; Han, Xiaoxing; Adstamongkonkul, Pichet; Popović, Zoran; Huang, Peigen; Bawendi, Moungi G.; Boucher, Yves; Jain, Rakesh K. (Nature Pub. Group, 2013)
      Cancer and stromal cells actively exert physical forces (solid stress) to compress tumour blood vessels, thus reducing vascular perfusion. Tumour interstitial matrix also contributes to solid stress, with hyaluronan ...
    • Blocking the formation of radiation–induced breast cancer stem cells 

      Wang, Yangyang; Li, Wende; Patel, Shalin S.; Cong, Juan; Zhang, Nan; Sabbatino, Francesco; Liu, Xiaoyan; Qi, Yuan; Huang, Peigen; Lee, Hang; Taghian, Alphonse; Li, Jian-Jian; DeLeo, Albert B.; Ferrone, Soldano; Epperly, Michael W.; Ferrone, Cristina R.; Ly, Amy; Brachtel, Elena F.; Wang, Xinhui (Impact Journals LLC, 2014)
      The goal of adjuvant (post-surgery) radiation therapy (RT) for breast cancer (BC) is to eliminate residual cancer cells, leading to better local tumor control and thus improving patient survival. However, radioresistance ...
    • Differential Effects of Sorafenib on Liver Versus Tumor Fibrosis Mediated by Stromal-Derived Factor 1 alpha/C-X-C Receptor Type 4 Axis and Myeloid Differentiation Antigen-Positive Myeloid Cell Infiltration in Mice 

      Chen, Yunching; Huang, Yuhui; Reiberger, Thomas; Duyverman, Annique M.; Huang, Peigen; Samuel, Rekha; Hiddingh, Lotte; Roberge, Sylvie; Koppel, Christina; Lauwers, Gregory Y.; Zhu, Andrew Xiuxuan; Jain, Rakesh K.; Duda, Dan Gabriel (Wiley-Blackwell, 2014)
      Sorafenib—a broad kinase inhibitor—is a standard therapy for advanced hepatocellular carcinoma (HCC) and has been shown to exert antifibrotic effects in liver cirrhosis, a precursor of HCC. However, the effects of sorafenib ...
    • Lifetime Increased Cancer Risk in Mice Following Exposure to Clinical Proton Beam–Generated Neutrons 

      Gerweck, Leo Edward; Huang, Peigen; Lu, Hsiao-ming; Paganetti, Harald; Zhou, Yenong (Elsevier BV, 2014)
      Purpose To evaluate the lifespan and risk of cancer following whole-body exposure of mice to neutrons generated by a passively scattered clinical SOBP proton beam. Methods and Materials Three hundred young adult ...
    • An orthotopic mouse model of hepatocellular carcinoma with underlying liver cirrhosis 

      Reiberger, Thomas; Chen, Yunching; Ramjiwan, Rakesh R.; Hato, Tai; Fan, Christopher; Samuel, Rekha; Roberge, Sylvie; Huang, Peigen; Lauwers, Gregory Y.; Zhu, Andrew Xiuxuan; Bardeesy, Nabeel; Jain, Rakesh K.; Duda, Dan Gabriel (Nature Publishing Group, 2015)
      Subcutaneous xenografts have been used for decades to study hepatocellular carcinoma (HCC). These models do not reproduce the specific pathophysiological features of HCCs, which occur in cirrhotic livers showing pronounced ...
    • Solid stress in brain tumours causes neuronal loss and neurological dysfunction and can be reversed by lithium 

      Seano, Giorgio; Nia, Hadi; Emblem, Kyrre E.; Datta, Meenal; Ren, Jun; Krishnan, Shanmugarajan; Kloepper, Jonas; Pinho, Marco C.; Ho, William W.; Ghosh, Mitrajit; Askoxylakis, Vasileios; Ferraro, Gino B.; Riedemann, Lars; Gerstner, Elizabeth; Batchelor, Tracy; Wen, Patrick; Lin, Nancy; Grodzinsky, Alan J.; Fukumura, Dai; Huang, Peigen; Baish, James W.; Padera, Timothy; Munn, Lance; Jain, Rakesh (Springer Science and Business Media LLC, 2019-01-07)
      The compression of brain tissue by a tumour mass is believed to be a major cause of the clinical symptoms seen in patients with brain cancer. However, the biological consequences of these physical stresses on brain tissue ...
    • Toll-like Receptor 4 Signaling Confers Cardiac Protection against Ischemic Injury via Inducible Nitric Oxide Synthase- and Soluble Guanylate Cyclase-dependent Mechanisms 

      Wang, E; Feng, Yan; Zhang, Ming; Zou, Lin; Li, Yan; Buys, Emmanuel; Huang, Peigen; Brouckaert, Peter; Chao, Wei (Ovid Technologies (Wolters Kluwer Health), 2011)
      Background: Prior administration of a small dose of lipopolysaccharide confers a cardiac protection against ischemia-reperfusion injury. However, the signaling mechanisms that control the protection are incompletely ...