Now showing items 1-6 of 6

    • Direct Recruitment of Polycomb Repressive Complex 1 to Chromatin by Core Binding Transcription Factors 

      Yu, Ming; Mazor, Tali; Huang, Hui; Huang, Hsuan-Ting; Kathrein, Katie L.; Woo, Andrew; Chouinard, Candace R.; Labadorf, Adam; Akie, Thomas E.; Moran, Tyler B.; Xie, Huafeng; Zacharek, Sima; Taniuchi, Ichiro; Roeder, Robert G.; Kim, Carla; Zon, Leonard Ira; Fraenkel, Ernest; Cantor, Alan B. (Elsevier BV, 2012)
      Polycomb repressive complexes (PRCs) play key roles in developmental epigenetic regulation. Yet the mechanisms that target PRCs to specific loci in mammalian cells remain incompletely understood. In this study we show that ...
    • Epigenetic Regulation of Hematopoiesis in Zebrafish 

      Huang, Hsuan-Ting (2012-11-02)
      The initiation of the hematopoietic program is orchestrated by key transcription factors that recruit chromatin regulators in order to activate or inhibit blood target gene expression. To generate a complete compendium of ...
    • Identification of Distal cis-Regulatory Elements at Mouse Mitoferrin Loci Using Zebrafish Transgenesis 

      Amigo, J. D.; Yu, M.; Troadec, M.-B.; Gwynn, B.; Cooney, J. D.; Lambert, A. J.; Chi, N. C.; Weiss, M. J.; Peters, L. L.; Kaplan, J.; Cantor, Alan B.; Paw, Barry Htin (American Society for Microbiology, 2011)
      Mitoferrin 1 (Mfrn1; Slc25a37) and mitoferrin 2 (Mfrn2; Slc25a28) function as essential mitochondrial iron importers for heme and Fe/S cluster biogenesis. A genetic deficiency of Mfrn1 results in a profound hypochromic ...
    • The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability 

      Chung, Jacky; Bauer, Daniel Evan; Ghamari, Alireza; Nizzi, C. P.; Deck, K. M.; Kingsley, P. D.; Yien, Yvette Yee; Huston, N. C.; Chen, C.; Schultz, I. J.; Dalton, Arthur J.; Wittig, Johannes; Palis, J.; Orkin, Stuart Holland; Lodish, H. F.; Eisenstein, R. S.; Cantor, Alan B.; Paw, Barry Htin (American Association for the Advancement of Science (AAAS), 2015)
      In multicellular organisms, the mechanisms by which diverse cell types acquire distinct amino acids and how cellular function adapts to their availability are fundamental questions in biology. We found that increased neutral ...
    • TIF1γ Controls Erythroid Cell Fate by Regulating Transcription Elongation 

      Bai, Xiaoying; Kim, Jonghwan; Yang, Zhongan; Jurynec, Michael J.; Akie, Thomas E.; Lee, Joseph; LeBlanc, Jocelyn; Sessa, Anna; Jiang, Hong; DiBiase, Anthony; Zhou, Yi; Grunwald, David J.; Lin, Shuo; Cantor, Alan B.; Orkin, Stuart Holland; Zon, Leonard Ira (Elsevier BV, 2010)
      Recent genome-wide studies have demonstrated that pausing of RNA polymerase II (Pol II) occurred on many vertebrate genes. By genetic studies in the zebrafish tif1γ mutant moonshine we found that loss of function of Pol ...
    • TMEM14C is required for erythroid mitochondrial heme metabolism 

      Yien, Yvette Yee; Robledo, Raymond F.; Schultz, Iman J.; Takahashi-Makise, Naoko; Gwynn, Babette; Bauer, Daniel Evan; Dass, Abhishek; Yi, Gloria; Li, Liangtao; Hildick-Smith, Gordon J.; Cooney, Jeffrey D.; Pierce, Eric Adam; Mohler, Kyla; Dailey, Tamara A.; Miyata, Non; Kingsley, Paul D.; Garone, Caterina; Hattangadi, Shilpa M.; Huang, Hui; Chen, Wen; Keenan, Ellen M.; Shah, Dhvanit I; Schlaeger, Thorsten M.; DiMauro, Salvatore; Orkin, Stuart Holland; Cantor, Alan B.; Palis, James; Koehler, Carla M.; Lodish, Harvey F.; Kaplan, Jerry B.; Ward, Diane M.; Dailey, Harry A.; Phillips, John Gary; Peters, Luanne L.; Paw, Barry Htin (American Society for Clinical Investigation, 2014)
      The transport and intracellular trafficking of heme biosynthesis intermediates are crucial for hemoglobin production, which is a critical process in developing red cells. Here, we profiled gene expression in terminally ...