Browsing by Author "Wen, Patrick"

Now showing items 1-14 of 14

    • AZD2171, a Pan-VEGF Receptor Tyrosine Kinase Inhibitor, Normalizes Tumor Vasculature and Alleviates Edema in Glioblastoma Patients 

      Batchelor, Tracy Todd; Sorensen, A; di Tomaso, Emmanuelle; Zhang, Wei-Ting; Duda, Dan Gabriel; Cohen, Kenneth S.; Kozak, Kevin R.; Cahill, Daniel P.; Chen, Poe-Jou; Zhu, Mingwang; Ancukiewicz, Marek; Mrugala, Maciej M.; Plotkin, Scott Randall; Drappatz, Jan; Louis, David N.; Ivy, Percy; Scadden, David Thomas; Benner, Thomas; Loeffler, Jay Steven; Wen, Patrick Yung Chih; Jain, Rakesh K. (Elsevier BV, 2007)
      Using MRI techniques, we show here that normalization of tumor vessels in recurrent glioblastoma patients by daily administration of AZD2171—an oral tyrosine kinase inhibitor of VEGF receptors—has rapid onset, is prolonged ...

    • DNA Fragmentation Simulation Method (FSM) and Fragment Size Matching Improve aCGH Performance of FFPE Tissues 

      Craig, Justin M.; Vena, Natalie; Idbaih, Ahmed; Fouse, Shaun D.; Ozek, Memet; Sav, Aydin; Margraf, Linda R.; Eberhart, Charles G.; Norden, Andrew D.; Ramkissoon, Shakti; Hill, D. Ashley; Kieran, Mark W.; Wen, Patrick Yung Chih; Loda, Massimo; Santagata, Sandro; Ligon, Keith Lloyd; Ligon, Azra Hadi (Public Library of Science, 2012)
      Whole-genome copy number analysis platforms, such as array comparative genomic hybridization (aCGH) and single nucleotide polymorphism (SNP) arrays, are transformative research discovery tools. In cancer, the identification ...

    • Glioblastoma Recurrence after Cediranib Therapy in Patients: Lack of "Rebound" Revascularization as Mode of Escape 

      di Tomaso, E.; Snuderl, M.; Kamoun, W. S.; Duda, Dan Gabriel; Auluck, P. K.; Fazlollahi, L.; Andronesi, Ovidiu C; Frosch, Matthew P.; Wen, Patrick Yung Chih; Plotkin, Scott Randall; Hedley-Whyte, E. Tessa; Sorensen, A; Batchelor, Tracy Todd; Jain, Radhika (American Association for Cancer Research (AACR), 2011)
      Recurrent glioblastomas (rGBM) invariably relapse after initial response to anti-VEGF therapy. There are two prevailing hypotheses on how these tumors escape antiangiogenic therapy: switch to VEGF-independent angiogenic ...

    • Improved Tumor Oxygenation and Survival in Glioblastoma Patients Who Show Increased Blood Perfusion After Cediranib and Chemoradiation 

      Batchelor, Tracy; Gerstner, Elizabeth; Emblem, Kyrre E.; Duda, Dan; Kalpathy-Cramer, Jayashree; Snuderl, Matija; Ancukiewicz, Marek; Polaskova, Pavlina; Pinho, Marco C.; Jennings, Dominique; Plotkin, Scott; Chi, Andrew S.; Eichler, April; Dietrich, Jorg; Hochberg, Fred H.; Lu-Emerson, Christine; Iafrate, Anthony; Ivy, S. Percy; Rosen, Bruce; Loeffler, Jay; Wen, Patrick; Sorenson, A. Greg; Jain, Rakesh (National Academy of Sciences, 2013-11-19)
      Antiangiogenic therapy has shown clear activity and improved survival benefit for certain tumor types. However, an incomplete understanding of the mechanisms of action of antiangiogenic agents has hindered optimization and ...

    • Increased Mobilisation of Circulating Endothelial Progenitors in von Hippel-Lindau Disease and Renal Cell Carcinoma 

      Zurita, A J; Norden-Zfoni, A; George, D; Heymach, J V; Bhatt, Rupal Satish; O'Neill, Allison Frances; Zhang, Liang; Wu, H.K.; Wen, Patrick Yung Chih; Sukhatme, Vikas Pandurang; Atkins, M.B. (Nature Publishing Group, 2011)
      Background: Circulating endothelial cells (CECs) are a candidate biomarker for monitoring angiogenesis in cancer. Circulating endothelial cell subsets are mobilised by angiogenic mediators. Because of the highly angiogenic ...

    • MAPK activation and HRAS mutation identified in pituitary spindle cell oncocytoma 

      Miller, Michael B.; Bi, Wenya Linda; Ramkissoon, Lori A.; Kang, Yun Jee; Abedalthagafi, Malak; Knoff, David S.; Agarwalla, Pankaj K.; Wen, Patrick Y.; Reardon, David A.; Alexander, Brian M.; Laws, Edward R.; Dunn, Ian F.; Beroukhim, Rameen; Ligon, Keith L.; Ramkissoon, Shakti H. (Impact Journals LLC, 2016)
      Pituitary spindle cell oncocytoma (SCO) is an uncommon primary pituitary neoplasm that presents with mass effect on adjacent neurovascular structures, similar to non-hormone-producing pituitary adenomas. To determine the ...

    • Morphological Characteristics of Brain Tumors Causing Seizures 

      Lee, Jong Woo; Wen, Patrick Yung Chih; Hurwitz, Shelley; Black, Peter McLaren; Kesari, Santosh; Drappatz, Jan; Golby, Alexandra Jacqueline; Wells, William Mercer; Warfield, Simon Keith; Kikinis, Ron; Bromfield, Edward B. (American Medical Association (AMA), 2010)
      Objective: To quantify size and localization differences between tumors presenting with seizures vs nonseizure neurological symptoms. Design: Retrospective imaging survey. We performed magnetic resonance imaging–based ...

    • Outcomes after discontinuation of antiepileptic drugs after surgery in patients with low grade brain tumors and meningiomas 

      Das, Rohit R.; Artsy, Elinor; Hurwitz, Shelley; Wen, Patrick Yung Chih; Black, Peter McLaren; Golby, Alexandra Jacqueline; Dworetzky, Barbara Ann; Lee, Jong Woo (Springer Nature, 2012)
      Low grade tumors are associated with a high risk of seizures. Prolonged use of antiepileptic drugs (AEDs) is associated with morbidity. Determining which patients can safely discontinue AEDs perioperatively is difficult. ...

    • Phase I trial with biomarker studies of vatalanib (PTK787) in patients with newly diagnosed glioblastoma treated with enzyme inducing anti-epileptic drugs and standard radiation and temozolomide 

      Gerstner, Elizabeth Robins; Eichler, April Fitzsimmons; Plotkin, Scott Randall; Drappatz, Jan; Doyle, Colin L.; Xu, Lei; Duda, Dan Gabriel; Wen, Patrick Yung Chih; Jain, Rakesh K.; Batchelor, Tracy Todd (Springer Nature, 2010)
      Targeting angiogenesis in glioblastoma (GBM) may improve patient outcome by normalizing tumor vasculature and improving delivery of chemotherapeutics and oxygen. Consequently, concomitant administration of small molecule ...

    • Phase II Study of Cediranib, an Oral Pan–Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor, in Patients With Recurrent Glioblastoma 

      Batchelor, Tracy Todd; Duda, Dan Gabriel; di Tomaso, Emmanuelle; Ancukiewicz, Marek; Plotkin, Scott Randall; Gerstner, Elizabeth Robins; Eichler, April Fitzsimmons; Drappatz, Jan; Hochberg, Fred; Benner, Thomas; Louis, David N.; Cohen, Kenneth S.; Chea, Houng; Exarhopoulos, Alexis; Loeffler, Jay Steven; Moses, Marsha; Ivy, Percy; Sorensen, A; Wen, Patrick Yung Chih; Jain, Rakesh K. (American Society of Clinical Oncology (ASCO), 2010)
      Purpose Glioblastoma is an incurable solid tumor characterized by increased expression of vascular endothelial growth factor (VEGF). We performed a phase II study of cediranib in patients with recurrent glioblastoma. ...

    • Phase II Study of Monthly Pasireotide LAR (SOM230C) for Recurrent or Progressive Meningioma 

      Norden, A. D.; Ligon, Keith Lloyd; Hammond, Samantha N.; Muzikansky, A.; Reardon, David Allen; Kaley, Thomas J.; Batchelor, Tracy Todd; Plotkin, Scott; Raizer, Jeffrey J.; Wong, Eric T.; Drappatz, Jan; Lesser, Glenn J.; Haidar, Sam; Beroukhim, Rameen; Lee, Eudocia Quant; Doherty, Lisa; Lafrankie, Debra; Gaffey, S. C.; Gerard, Mary; Smith, Katrina H.; McCluskey, C.; Phuphanich, Surasak; Wen, Patrick Yung Chih (Ovid Technologies (Wolters Kluwer Health), 2014)
      Objective: A subset of meningiomas recur after surgery and radiation therapy, but no medical therapy for recurrent meningioma has proven effective. Methods: Pasireotide LAR is a long-acting somatostatin analog that may ...

    • Rapid Intraoperative Molecular Characterization of Glioma 

      Shankar, Ganesh Mani; Francis, Joshua M.; Rinne, Mikael Lee; Ramkissoon, Shakti; Huang, Franklin W; Venteicher, Andrew S; Akama-Garren, Elliot H.; Kang, Yun Jee; Lelic, Nina; Kim, James C.; Brown, Loreal E.; Charbonneau, Sarah K; Golby, Alexandra Jacqueline; Sekhar Pedamallu, Chandra; Hoang, Mai P; Sullivan, Ryan Joseph; Cherniack, Andrew D.; Garraway, Levi Alexander; Stemmer-Rachamimov, Anat; Reardon, David Allen; Wen, Patrick Yung Chih; Brastianos, Priscilla Kalliope; Curry, William Thomas; Barker, Frederick George; Hahn, William Chun; Nahed, Brian Vala; Ligon, Keith Lloyd; Louis, David N.; Cahill, Daniel P.; Meyerson, Matthew Langer (American Medical Association (AMA), 2015)
      IMPORTANCE: Conclusive intraoperative pathologic confirmation of diffuse infiltrative glioma guides the decision to pursue definitive neurosurgical resection. Establishing the intraoperative diagnosis by histologic analysis ...

    • Solid stress in brain tumours causes neuronal loss and neurological dysfunction and can be reversed by lithium 

      Seano, Giorgio; Nia, Hadi; Emblem, Kyrre E.; Datta, Meenal; Ren, Jun; Krishnan, Shanmugarajan; Kloepper, Jonas; Pinho, Marco C.; Ho, William W.; Ghosh, Mitrajit; Askoxylakis, Vasileios; Ferraro, Gino B.; Riedemann, Lars; Gerstner, Elizabeth; Batchelor, Tracy; Wen, Patrick; Lin, Nancy; Grodzinsky, Alan J.; Fukumura, Dai; Huang, Peigen; Baish, James W.; Padera, Timothy; Munn, Lance; Jain, Rakesh (Springer Science and Business Media LLC, 2019-01-07)
      The compression of brain tissue by a tumour mass is believed to be a major cause of the clinical symptoms seen in patients with brain cancer. However, the biological consequences of these physical stresses on brain tissue ...

    • Vessel Architectural Imaging Identifies Cancer Patient Responders to Anti-angiogenic Therapy 

      Emblem, Kyrre E.; Mouridsen, Kim; Bjornerud, Atle; Farrar, Christian T.; Jennings, Dominique; Borra, Ronald J. H.; Wen, Patrick Y.; Ivy, Percy; Batchelor, Tracy T.; Rosen, Bruce R.; Jain, Rakesh K.; Sorensen, A. Gregory (2013)
      Measurement of vessel caliber by Magnetic Resonance Imaging (MRI) is a valuable technique for in vivo monitoring of hemodynamic status and vascular development, especially in the brain. Here, we introduce a new paradigm ...