Now showing items 1-10 of 10

    • Combination inhibition of PI3K and mTORC1 yields durable remissions in orthotopic patient-derived xenografts of HER2-positive breast cancer brain metastases 

      Ni, Jing; Ramkissoon, Shakti H.; Xie, Shaozhen; Goel, Shom; Stover, Daniel G.; Guo, Hanbing; Luu, Victor; Marco, Eugenio; Ramkissoon, Lori A.; Kang, Yun Jee; Hayashi, Marika; Nguyen, Quang-De; Ligon, Azra H.; Du, Rose; Claus, Elizabeth B.; Alexander, Brian M.; Yuan, Guo-Cheng; Wang, Zhigang C.; Iglehart, J. Dirk; Krop, Ian E.; Roberts, Thomas M.; Winer, Eric P.; Lin, Nancy U.; Ligon, Keith L.; Zhao, Jean J. (2016)
      Brain metastases represent the greatest clinical challenge in treating HER2-positive breast cancer. We report the development of orthotopic patient-derived xenografts (PDXs) of HER2-expressing breast cancer brain metastases ...
    • Effective use of PI3K inhibitor BKM120 and PARP inhibitor Olaparib to treat PIK3CA mutant ovarian cancer 

      Wang, Dong; Wang, Min; Jiang, Nan; Zhang, Yuan; Bian, Xing; Wang, Xiaoqing; Roberts, Thomas M.; Zhao, Jean J.; Liu, Pixu; Cheng, Hailing (Impact Journals LLC, 2016)
      Recent preclinical studies revealed the efficacy of combined use of PI3K inhibitor BKM120 and PARP inhibitor Olaparib in breast and prostate cancers. The current study investigated the effect of such drug combination on ...
    • In Vivo and in Vitro Characterization of the Tumor Suppressive Function of INPP4B 

      Chew, Chen Li (2015-05-16)
      The phosphatases PTEN and INPP4B are frequently deregulated in human cancer and have been proposed to act as tumor suppressor genes by coordinately antagonizing PI3K/AKT signaling. While the function of PTEN has been ...
    • MELK is an oncogenic kinase essential for mitotic progression in basal-like breast cancer cells 

      Wang, Yubao; Lee, Young-Mi; Baitsch, Lukas; Huang, Alan; Xiang, Yi; Tong, Haoxuan; Lako, Ana; Von, Thanh; Choi, Christine; Lim, Elgene; Min, Junxia; Li, Li; Stegmeier, Frank; Schlegel, Robert; Eck, Michael J; Gray, Nathanael S; Mitchison, Timothy J; Zhao, Jean J (eLife Sciences Publications, Ltd, 2014)
      Despite marked advances in breast cancer therapy, basal-like breast cancer (BBC), an aggressive subtype of breast cancer usually lacking estrogen and progesterone receptors, remains difficult to treat. In this study, we ...
    • NTRK2 activation cooperates with PTEN deficiency in T-ALL through activation of both the PI3K–AKT and JAK–STAT3 pathways 

      Yuzugullu, Haluk; Von, Thanh; Thorpe, Lauren M; Walker, Sarah R; Roberts, Thomas M; Frank, David A; Zhao, Jean J (Nature Publishing Group, 2016)
      Loss of PTEN, a negative regulator of the phosphoinositide 3-kinase signaling pathway, is a frequent event in T-cell acute lymphoblastic leukemia, suggesting the importance of phosphoinositide 3-kinase activity in this ...
    • PAK1 is a Breast Cancer Oncogene that Coordinately Activates MAPK and MET Signaling 

      Shrestha, Yashaswi; Schafer, Eric J.; Boehm, Jesse S.; He, Frank; Wang, Shumei; Barretina, Jordi; Thomas, Sapana Rachael; Du, Jinyan; Weir, Barbara Ann; Zhao, Jean J.; Golub, Todd R.; Beroukhim, Rameen; Hahn, William C.; Polyak, Kornelia (Nature Publishing Group, 2012)
      Activating mutations in the RAS family or BRAF frequently occur in many types of human cancers but are rarely detected in breast tumors. However, activation of the RAS-RAF-MEK-ERK Mitogen-Activated Protein Kinase (MAPK) ...
    • PI3K in the ventromedial hypothalamic nucleus mediates estrogenic actions on energy expenditure in female mice 

      Saito, Kenji; He, Yanlin; Yang, Yongjie; Zhu, Liangru; Wang, Chunmei; Xu, Pingwen; Hinton, Antentor Othrell; Yan, Xiaofeng; Zhao, Jean; Fukuda, Makoto; Tong, Qingchun; Clegg, Deborah J.; Xu, Yong (Nature Publishing Group, 2016)
      Estrogens act in the ventromedial hypothalamic nucleus (VMH) to regulate body weight homeostasis. However, the molecular mechanisms underlying these estrogenic effects are unknown. We show that activation of estrogen ...
    • A PI3K p110β–Rac signalling loop mediates Pten-loss-induced perturbation of haematopoiesis and leukaemogenesis 

      Yuzugullu, Haluk; Baitsch, Lukas; Von, Thanh; Steiner, Allison; Tong, Haoxuan; Ni, Jing; Clayton, Linda K.; Bronson, Roderick; Roberts, Thomas M.; Gritsman, Kira; Zhao, Jean J. (Nature Pub. Group, 2015)
      The tumour suppressor PTEN, which antagonizes PI3K signalling, is frequently inactivated in haematologic malignancies. In mice, deletion of PTEN in haematopoietic stem cells (HSCs) causes perturbed haematopoiesis, ...
    • Rac1-mediated membrane raft localization of PI3K/p110β is required for its activation by GPCRs or PTEN loss 

      Cizmecioglu, Onur; Ni, Jing; Xie, Shaozhen; Zhao, Jean J; Roberts, Thomas M (eLife Sciences Publications, Ltd, 2016)
      We aimed to understand how spatial compartmentalization in the plasma membrane might contribute to the functions of the ubiquitous class IA phosphoinositide 3-kinase (PI3K) isoforms, p110α and p110β. We found that p110β ...
    • Therapeutic Implications of GIPC1 Silencing in Cancer 

      Chittenden, Thomas W.; Pak, Jane; Rubio, Renee; Holton, Kristina; Prendergast, Niall; Glinskii, Vladimir; Schwede, Mathew; Howe, Eleanor A.; Aryee, Martin; Sultana, Razvan; Lanahan, Anthony A.; Holmes, Chris; Cheng, Hailing; Cai, Yi; Culhane, Aedin; Bentink, Stefan; Mar, Jessica Cara; Taylor, Jennifer; Hahn, William C.; Zhao, Jean J.; Iglehart, James Dirk; Quackenbush, John (Public Library of Science, 2010)
      GIPC1 is a cytoplasmic scaffold protein that interacts with numerous receptor signaling complexes, and emerging evidence suggests that it plays a role in tumorigenesis. GIPC1 is highly expressed in a number of human ...