Now showing items 1-20 of 38

    • Anaphylactic shock depends on PI3K and eNOS-derived NO 

      Cauwels, Anje; Janssen, Ben; Buys, Emmanuel; Sips, Patrick; Brouckaert, Peter (American Society for Clinical Investigation, 2006)
      Anaphylactic shock is a sudden, life-threatening allergic reaction associated with severe hypotension. Platelet-activating factor (PAF) is implicated in the cardiovascular dysfunctions occurring in various shock syndromes, ...
    • Assessing Murine Resistance Artery Function Using Pressure Myography 

      Shahid, Mohd; Buys, Emmanuel (MyJove Corporation, 2013)
      Pressure myograph systems are exquisitely useful in the functional assessment of small arteries, pressurized to a suitable transmural pressure. The near physiological condition achieved in pressure myography permits in-depth ...
    • Association of Dietary Nitrate Intake With Primary Open-Angle Glaucoma 

      Kang, Jae Hee; Willett, Walter C.; Rosner, Bernard Alfred; Buys, Emmanuel; Wiggs, Janey Lee; Pasquale, Louis (American Medical Association (AMA), 2016)
      IMPORTANCE Nitric oxide signaling alterations in outflow facility and retinal blood flow autoregulation are implicated in primary open-angle glaucoma (POAG). Nitric oxide donation has emerged as a POAG therapeutic target. ...
    • Atrial natriuretic peptide is negatively regulated by microRNA-425 

      Arora, Pankaj; Wu, Connie; Khan, Abigail May; Bloch, Donald Bendit; Davis-Dusenbery, Brandi Nicole; Ghorbani, Anahita; Spagnolli, Ester; Martinez, Andrew; Ryan, Allicia; Tainsh, Laurel T.; Kim, Samuel M; Rong, Jian; Huan, Tianxiao; Freedman, Jane E.; Levy, Daniel; Miller, Karen Klahr; Hata, Akiko; Del Monte, Federica; Vandenwijngaert, Sara; Swinnen, Melissa; Janssens, Stefan; Holmes, Tara M.; Buys, Emmanuel; Bloch, Kenneth Daniel; Newton-Cheh, Christopher Holmes; Wang, Thomas (American Society for Clinical Investigation, 2013)
      Numerous common genetic variants have been linked to blood pressure, but no underlying mechanism has been elucidated. Population studies have revealed that the variant rs5068 (A/G) in the 3′ untranslated region of NPPA, ...
    • Brown Adipose Tissue Blood Flow and Mass in Obesity: A Contrast Ultrasound Study in Mice 

      Clerte, Maëva; Baron, David William; Brouckaert, Peter; Ernande, Laura; Raher, Michael J.; Flynn, Aidan W.; Picard, Michael Howard; Bloch, Kenneth; Buys, Emmanuel; Scherrer-Crosbie, Marielle (Elsevier BV, 2013)
      Background: When activated by the sympathetic nervous system, brown adipose tissue (BAT) increases energy expenditure to produce heat. Augmenting BAT mass or increasing BAT activation could potentially be used to decrease ...
    • Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation 

      O'Rourke, Caitlin; Shelton, Georgia; Hutcheson, Joshua; Burke, Megan F.; Martyn, Trejeeve; Thayer, Timothy E.; Shakartzi, Hannah R.; Buswell, Mary D.; Tainsh, Robert; Yu, Binglan; Bagchi, Aranya; Rhee, David Kwan; Wu, Connie; Derwall, Matthias; Buys, Emmanuel; Yu, Paul B.; Bloch, Kenneth; Aikawa, Elena; Bloch, Donald Bendit; Malhotra, Rajeev (MyJove Corporation, 2016)
      Cardiovascular disease is the leading cause of morbidity and mortality in the world. Atherosclerotic plaques, consisting of lipid-laden macrophages and calcification, develop in the coronary arteries, aortic valve, aorta, ...
    • Cardiovascular and pharmacological implications of haem-deficient NO-unresponsive soluble guanylate cyclase knock-in mice 

      Thoonen, Robrecht; Cauwels, Anje; Decaluwe, Kelly; Geschka, Sandra; Tainsh, Robert; Delanghe, Joris; Hochepied, Tino; De Cauwer, Lode; Rogge, Elke; Voet, Sofie; Sips, Patrick; Karas, Richard H.; Bloch, Kenneth; Vuylsteke, Marnik; Stasch, Johannes-Peter; Van de Voorde, Johan; Buys, Emmanuel; Brouckaert, Peter (Springer Nature, 2015)
      Oxidative stress, a central mediator of cardiovascular disease, results in loss of the prosthetic haem group of soluble guanylate cyclase (sGC), preventing its activation by nitric oxide (NO). Here we introduce Apo-sGC ...
    • Decreased Soluble Guanylate Cyclase Contributes to Cardiac Dysfunction Induced by Chronic Doxorubicin Treatment in Mice 

      Vandenwijngaert, Sara; Swinnen, Melissa; Walravens, Ann-Sophie; Beerens, Manu Eddy Maria; Gillijns, Hilde; Caluwé, Ellen; Tainsh, Robert; Nathan, Daniel I.; Allen, Kaitlin; Brouckaert, Peter; Bartunek, Jozef; Scherrer-Crosbie, Marielle; Bloch, Kenneth; Bloch, Donald Bendit; Janssens, Stefan P.; Buys, Emmanuel (Mary Ann Liebert Inc, 2017)
      Aims: The use of doxorubicin, a potent chemotherapeutic agent, is limited by cardiotoxicity. We tested the hypothesis that decreased soluble guanylate cyclase (sGC) enzyme activity contributes to the development of ...
    • Effect of Phosphodiesterase Inhibition on Insulin Resistance in Obese Individuals 

      Ho, Jennifer E.; Arora, Pankaj; Walford, Geoffrey A.; Ghorbani, Anahita; Guanaga, Derek P.; Dhakal, Bishnu P.; Nathan, Daniel I.; Buys, Emmanuel S.; Florez, Jose C.; Newton‐Cheh, Christopher; Lewis, Gregory D.; Wang, Thomas J. (Blackwell Publishing Ltd, 2014)
      Background: Obesity is associated with cardiometabolic disease, including insulin resistance (IR) and diabetes. Cyclic guanosine monophosphate (cGMP) signaling affects energy balance, IR, and glucose metabolism in experimental ...
    • Effects of transdermal testosterone on natriuretic peptide levels in women: a randomized placebo-controlled pilot study 

      Lin, Eleanor; McCabe, Elizabeth; Newton-Cheh, Christopher Holmes; Bloch, Kenneth Daniel; Buys, Emmanuel; Wang, Thomas; Miller, Karen Klahr (Elsevier BV, 2012)
      Objective: To investigate whether testosterone administration alters natriuretic peptide levels in women. Design: Three-month, double-blind, randomized, placebo-controlled study. Setting: Clinical research center. Patient(s): ...
    • Functional brown adipose tissue limits cardiomyocyte injury and adverse remodeling in catecholamine-induced cardiomyopathy 

      Thoonen, Robrecht; Ernande, Laura; Cheng, Juan; Nagasaka, Yasuko; Yao, Vincent; Miranda-Bezerra, Alexandre; Chen, Chan; Chao, Wei; Panagia, Marcello; Sosnovik, David E.; Puppala, Dheeraj; Armoundas, Antonis A.; Hindle, Allyson; Bloch, Kenneth; Buys, Emmanuel; Scherrer-Crosbie, Marielle (Elsevier BV, 2015)
      Brown adipose tissue (BAT) has well recognized thermogenic properties mediated by uncoupling protein 1 (UCP1); more recently, BAT has been demonstrated to modulate cardiovascular risk factors. To investigate whether BAT ...
    • Gender-Specific Modulation of the Response to Arterial Injury by Soluble Guanylate Cyclase α1 

      Vermeersch, Pieter; Pokreisz, Peter; Marsboom, Glenn; Gillijns, Hilde; Pellens, Marijke; Dewerchin, Mieke; Brouckaert, Peter; Janssens, Stefan; Buys, Emmanuel; Sips, Patrick; Bloch, Kenneth Daniel (Bentham Open, 2009)
      Objective: Soluble guanylate cyclase (sGC), a heterodimer composed of α and β subunits, synthesizes cGMP in response to nitric oxide (NO). NO modulates vascular tone and structure but the relative contributions of ...
    • Genetic modification of hypertension by sGCa1 

      Sips, Patrick; Buys, Emmanuel (Elsevier BV, 2013)
      Hypertension is an important modifiable risk factor for coronary heart disease, congestive heart failure, stroke, end-stage renal disease, and peripheral vascular disease, but many of the molecular mechanisms and genetic ...
    • Genetic modifiers of hypertension in soluble guanylate cyclase α1–deficient mice 

      Buys, Emmanuel; Raher, Michael J.; Kirby, Andrew; Mohd, Shahid; Baron, David William; Hayton, Sarah R.; Tainsh, Laurel T.; Sips, Patrick; Rauwerdink, Kristen M.; Yan, Qingshang; Tainsh, Robert E; Shakartzi, Hannah R.; Stevens, Christine; Decaluwé, Kelly; Rodrigues-Machado, Maria da Gloria; Malhotra, Rajeev; Van de Voorde, Johan; Wang, Tong; Brouckaert, Peter; Daly, Mark Joseph; Bloch, Kenneth Daniel (American Society for Clinical Investigation, 2012)
      Nitric oxide (NO) plays an essential role in regulating hypertension and blood flow by inducing relaxation of vascular smooth muscle. Male mice deficient in a NO receptor component, the α1 subunit of soluble guanylate ...
    • Heme deficiency of soluble guanylate cyclase induces gastroparesis 

      Cosyns, S. M. R.; Dhaese, I.; Thoonen, Robrecht; Buys, Emmanuel; Vral, A.; Brouckaert, P.; Lefebvre, R. A. (Wiley-Blackwell, 2013)
      Background: Soluble guanylate cyclase (sGC) is the principal target of nitric oxide (NO) to control gastrointestinal motility. The consequence on nitrergic signaling and gut motility of inducing a heme-free status of sGC, ...
    • High level accumulation of single-chain variable fragments in the cytosol of transgenicPetunia hybrida 

      De Jaeger, Geert; Buys, Emmanuel; Eeckhout, Dominique; De Wilde, Chris; Jacobs, Anni; Kapila, Jyoti; Angenon, Geert; Van Montagu, Marc; Gerats, , Tom; Depicker, Ann (Wiley-Blackwell, 1999)
      The accumulation of five murine single-chain variable fragments, binding to dihydroflavonol 4-reductase, was analyzed in transgenic Petunia hybrida plants. The five scFv-encoding sequences were cloned in an optimized plant ...
    • In Vivo Noninvasive Characterization of Brown Adipose Tissue Blood Flow by Contrast Ultrasound in Mice 

      Baron, David M.; Clerte, Maeva; Brouckaert, Peter; Raher, Michael J.; Flynn, Aidan W.; Zhang, Haihua; Carter, Edward Albert; Picard, Michael Howard; Bloch, Kenneth Daniel; Buys, Emmanuel; Scherrer-Crosbie, Marielle (Ovid Technologies (Wolters Kluwer Health), 2012)
      Background—Interventions to increase brown adipose tissue (BAT) volume and activation are being extensively investigated as therapies to decrease the body weight in obese subjects. Noninvasive methods to monitor these ...
    • Inhaled Nitric Oxide Improves Outcomes After Successful Cardiopulmonary Resuscitation in Mice 

      Minamishima, Shizuka; Kida, Kotaro; Tokuda, Kentaro; Wang, Huifang; Sips, Patrick; Kosugi, Shizuko; Mandeville, Joseph B.; Buys, Emmanuel; Brouckaert, Peter; Liu, Philip K.; Liu, Christina; Bloch, Kenneth Daniel; Ichinose, Fumito (Ovid Technologies (Wolters Kluwer Health), 2011)
      Background—Sudden cardiac arrest (CA) is a leading cause of death worldwide. Breathing nitric oxide (NO) reduces ischemia/reperfusion injury in animal models and in patients. The objective of this study was to learn whether ...
    • Inhibition of Bone Morphogenetic Protein Signal Transduction Prevents the Medial Vascular Calcification Associated with Matrix Gla Protein Deficiency 

      Malhotra, Rajeev; Burke, Megan F.; Martyn, Trejeeve; Shakartzi, Hannah R.; Thayer, Timothy E.; O’Rourke, Caitlin; Li, Pingcheng; Derwall, Matthias; Spagnolli, Ester; Kolodziej, Starsha A.; Hoeft, Konrad; Mayeur, Claire; Jiramongkolchai, Pawina; Kumar, Ravindra; Buys, Emmanuel S.; Yu, Paul B.; Bloch, Kenneth D.; Bloch, Donald B. (Public Library of Science, 2015)
      Objective: Matrix Gla protein (MGP) is reported to inhibit bone morphogenetic protein (BMP) signal transduction. MGP deficiency is associated with medial calcification of the arterial wall, in a process that involves both ...
    • New insights into the role of soluble guanylate cyclase in blood pressure regulation 

      Buys, Emmanuel; Sips, Patrick (Ovid Technologies (Wolters Kluwer Health), 2014)
      Purpose of review: Nitric oxide (NO) – soluble guanylate cyclase (sGC)-dependent signaling mechanisms have a profound effect on the regulation of blood pressure. In this review, we will discuss recent findings in the field ...