Now showing items 1-20 of 105

    • ABCB1 (MDR1) polymorphisms and ovarian cancer progression and survival: A comprehensive analysis from the Ovarian Cancer Association Consortium and The Cancer Genome Atlas 

      Johnatty, Sharon E.; Beesley, Jonathan; Gao, Bo; Chen, Xiaoqing; Lu, Yi; Law, Matthew H.; Henderson, Michelle J.; Russell, Amanda J.; Hedditch, Ellen L.; Emmanuel, Catherine; Fereday, Sian; Webb, Penelope M.; Goode, Ellen L.; Vierkant, Robert A.; Fridley, Brooke L.; Cunningham, Julie M; Fasching, Peter A.; Beckmann, Matthias W.; Ekici, Arif B.; Hogdall, Estrid; Kjaer, Susanne K.; Jensen, Allan; Hogdall, Claus; Brown, Robert; Paul, Jim; Lambrechts, Sandrina; Despierre, Evelyn; Vergote, Ignace; Lester, Jenny; Karlan, Beth Y.; Heitz, Florian; du Bois, Andreas; Harter, Philipp; Schwaab, Ira; Bean, Yukie; Pejovic, Tanja; Levine, Douglas A.; Goodman, Marc T.; Camey, Michael E.; Thompson, Pamela J.; Lurie, Galina; Shildkraut, Joellen; Berchuck, Andrew; Terry, Kathryn Lynne; Cramer, Daniel William; Norris, Murray D.; Haber, Michelle; MacGregor, Stuart; deFazio, Anna; Chenevix-Trench, Georgia (Elsevier BV, 2013)
      Objective ABCB1 encodes the multi-drug efflux pump P-glycoprotein (P-gp) and has been implicated in multi-drug resistance. We comprehensively evaluated this gene and flanking regions for an association with clinical ...
    • ABO blood group and incidence of epithelial ovarian cancer 

      Gates, Margaret A.; Wolpin, Brian M.; Cramer, Daniel William; Hankinson, Susan Elizabeth; Tworoger, Shelley Slate (Wiley-Blackwell, 2010)
      Previous studies have observed an association between ABO blood group and risk of certain malignancies, including ovarian cancer; however, no prospective studies of the association with ovarian cancer risk are available. ...
    • ABO blood group and risk of epithelial ovarian cancer within the Ovarian Cancer Association Consortium 

      Poole, Elizabeth M.; Gates, Margaret A.; High, Brigit A.; Chanock, Stephen J.; Cramer, Daniel William; Cunningham, Julie M.; Fridley, Brooke L.; Gayther, Simon A.; Goode, Ellen L.; Iversen, Edwin S.; Lissowska, Jolanta; Weber, Rachel T. Palmieri; Pharoah, Paul D. P.; Phelan, Catherine M.; Ramus, Susan J.; Schildkraut, Joellen M.; Sutphen, Rebecca; Tsai, Ya-Yu; Tyrer, Jonathan; Vierkant, Robert A.; Wentzensen, Nicolas; Yang, Hannah P.; Terry, Kathryn Lynne; Tworoger, Shelley Slate (Springer Science + Business Media, 2012)
      Purpose Previous studies have examined the association between ABO blood group and ovarian cancer risk, with inconclusive results. Methods In 8 studies participating in the Ovarian Cancer Association Consortium ...
    • Activated networking of platelet activating factor receptor and FAK/STAT1 induces malignant potential in BRCA1-mutant at-risk ovarian epithelium 

      Zhang, Lifang; Wang, Dan; Jiang, Wei; Edwards, Dale; Qiu, Weiliang; Barroilhet, Lisa M; Rho, Jung-hyun; Jin, Lianjin; Seethappan, Vanitha; Vitonis, Allison; Wang, Jianliu; Mok, Samuel C; Crum, Christopher Paul; Cramer, Daniel William; Ye, Bin (Springer Science + Business Media, 2010)
      Objectives It is essential to understand the molecular basis of ovarian cancer etiology and tumor development to provide more effective preventive and therapeutic approaches to reduce mortality. Particularly, the molecular ...
    • Analysis of Multiple-cycle Data From Couples Undergoing In Vitro Fertilization 

      Missmer, Stacey Ann; Pearson, Kimberly Hope; Ryan, Louise Marie; Meeker, John D.; Cramer, Daniel William; Hauser, Russ B. (Ovid Technologies (Wolters Kluwer Health), 2011)
      The number of in vitro fertilization (IVF) cycles in the U.S. increased from fewer than 46,000 in 1995 to more than 120,000 in 2005. IVF and other assisted reproductive technology (ART) data are routinely collected and ...
    • Analysis of Over 10,000 Cases Finds No Association between Previously Reported Candidate Polymorphisms and Ovarian Cancer Outcome 

      White, K. L.; Vierkant, R. A.; Fogarty, Z. C.; Charbonneau, B.; Block, M. S.; Pharoah, P. D. P.; Chenevix-Trench, G.; Rossing, M. A.; Cramer, Daniel William; Pearce, C. L.; Schildkraut, J. M.; Menon, U.; Kjaer, S. K.; Levine, D. A.; Gronwald, J.; Culver, H. A.; Whittemore, A. S.; Karlan, B. Y.; Lambrechts, D.; Wentzensen, N.; Kupryjanczyk, J.; Chang-Claude, J.; Bandera, E. V.; Hogdall, E.; Heitz, F.; Kaye, S. B.; Fasching, P. A.; Campbell, I.; Goodman, M. T.; Pejovic, T.; Bean, Y.; Lurie, G.; Eccles, D.; Hein, A.; Beckmann, M. W.; Ekici, A. B.; Paul, J.; Brown, R.; Flanagan, J. M.; Harter, P.; du Bois, A.; Schwaab, I.; Hogdall, C. K.; Lundvall, L.; Olson, S. H.; Orlow, I.; Paddock, L. E.; Rudolph, A.; Eilber, U.; Dansonka-Mieszkowska, A.; Rzepecka, I. K.; Ziolkowska-Seta, I.; Brinton, L.; Yang, H.; Garcia-Closas, M.; Despierre, E.; Lambrechts, S.; Vergote, I.; Walsh, C.; Lester, J.; Sieh, W.; McGuire, V.; Rothstein, J. H.; Ziogas, A.; Lubinski, J.; Cybulski, C.; Menkiszak, J.; Jensen, A.; Gayther, S. A.; Ramus, S. J.; Gentry-Maharaj, A.; Berchuck, A.; Wu, A. H.; Pike, M. C.; Van DenBerg, D.; Terry, Kathryn Lynne; Vitonis, A. F.; Doherty, J. A.; Johnatty, S. E.; deFazio, A.; Song, H.; Tyrer, J.; Sellers, T. A.; Phelan, C. M.; Kalli, K. R.; Cunningham, J. M.; Fridley, B. L.; Goode, E. L. (American Association for Cancer Research (AACR), 2013)
      Background Ovarian cancer is a leading cause of cancer-related death among women. In an effort to understand contributors to disease outcome, we evaluated single-nucleotide polymorphisms (SNPs) previously associated ...
    • Androgen Receptor Cytosine, Adenine, Guanine Repeats, and Haplotypes in Relation to Ovarian Cancer Risk 

      Terry, Kathryn Lynne; De Vivo, Immaculata; Titus-Ernstoff, Linda; Shih, Mei-Chiung; Cramer, Daniel William (American Association for Cancer Research (AACR), 2005)
      Biological and epidemiologic evidence suggest that androgen or its receptor may play a role in ovarian cancer pathogenesis. The most notable genetic factor influencing androgen receptor (AR) activity is the functional ...
    • Anti-MUC1 Antibodies and Ovarian Cancer Risk: Prospective Data from the Nurses' Health Studies 

      Pinheiro, S. P.; Hankinson, Susan Elizabeth; Tworoger, Shelley Slate; Rosner, Bernard Alfred; McKolanis, J. R.; Finn, O. J.; Cramer, Daniel William (American Association for Cancer Research (AACR), 2010)
      The surface epithelial glycoprotein MUC1 becomes overexpressed and hypoglycosylated in adenocarcinomas; similar changes occur during nonmalignant inflammatory events. Antibodies developed against tumor-like MUC1 in response ...
    • Application of Protein Microarrays for Multiplexed Detection of Antibodies to Tumor Antigens in Breast Cancer 

      Anderson, Karen S.; Ramachandran, Niroshan; Wong, Jessica; Raphael, Jacob V.; Hainsworth, Eugenie; Demirkan, Gokhan; Cramer, Daniel William; Aronzon, Dina; Hodi, Frank Stephen; Harris, Lyndsay; Logvinenko, Tanya; LaBaer, Joshua (American Chemical Society (ACS), 2008)
      There is strong preclinical evidence that cancer, including breast cancer, undergoes immune surveillance. This continual monitoring, by both the innate and the adaptive immune systems, recognizes changes in protein expression, ...
    • Assessing Ovarian Cancer Risk When Considering Elective Oophorectomy at the Time of Hysterectomy 

      Vitonis, Allison F.; Titus-Ernstoff, Linda; Cramer, Daniel William (Ovid Technologies (Wolters Kluwer Health), 2011)
      Objective To develop a risk-factor score that may provide additional guidance to women and their physicians regarding elective bilateral salpingo-oophorectomy at the time of hysterectomy. Methods From a case–control ...
    • Association Between Menopausal Estrogen-Only Therapy and Ovarian Carcinoma Risk 

      Lee, Alice W.; Ness, Roberta B.; Roman, Lynda D.; Terry, Kathryn Lynne; Schildkraut, Joellen M.; Chang-Claude, Jenny; Doherty, Jennifer A.; Menon, Usha; Cramer, Daniel William; Gayther, Simon A.; Risch, Harvey; Gentry-Maharaj, Aleksandra; Goodman, Marc T.; Modugno, Francesmary; Eilber, Ursula; Moysich, Kirsten B.; Berchuck, Andrew; Rossing, Mary Anne; Jensen, Allan; Wicklund, Kristine G.; Cushing-Haugen, Kara L.; Hogdall, Estrid; Rudolph, Anja; Thompson, Pamela J.; Wilkens, Lynne R.; Kjaer, Susanne K.; Carney, Michael E.; Stram, Daniel O.; Ramus, Susan J.; Wu, Anna H.; Pike, Malcolm C.; Pearce, Celeste Leigh (Ovid Technologies (Wolters Kluwer Health), 2016)
      OBJECTIVE: To describe the association between postmenopausal estrogen-only therapy use and risk of ovarian carcinoma, specifically with regard to disease histotype and duration and timing of use. METHODS: We conducted a ...
    • The association between socioeconomic status and tumour stage at diagnosis of ovarian cancer: A pooled analysis of 18 case-control studies 

      Præstegaard, Camilla; Kjaer, Susanne K.; Nielsen, Thor S.S.; Jensen, Signe M.; Webb, Penelope M.; Nagle, Christina M.; Høgdall, Estrid; Risch, Harvey A.; Rossing, Mary Anne; Doherty, Jennifer A.; Wicklund, Kristine G.; Goodman, Marc T.; Modugno, Francesmary; Moysich, Kirsten; Ness, Roberta B.; Edwards, Robert P.; Goode, Ellen L.; Winham, Stacey J.; Fridley, Brooke L.; Cramer, Daniel William; Terry, Kathryn Lynne; Schildkraut, Joellen M.; Berchuck, Andrew; Bandera, Elisa V.; Paddock, Lisa; Kiemeney, Lambertus A.; Massuger, Leon F.; Wentzensen, Nicolas; Pharoah, Paul; Song, Honglin; Whittemore, Alice S.; McGuire, Valerie; Sieh, Weiva; Rothstein, Joseph; Anton-Culver, Hoda; Ziogas, Argyrios; Menon, Usha; Gayther, Simon A.; Ramus, Susan J.; Gentry-Maharaj, Aleksandra; Wu, Anna H.; Pearce, Celeste L.; Pike, Malcolm C.; Lee, Alice W.; Chang-Claude, Jenny; Jensen, Allan (Elsevier BV, 2016)
      PURPOSE: Socioeconomic status (SES) is a known predictor of survival for several cancers and it has been suggested that SES differences affecting tumour stage at diagnosis may be the most important explanatory factor for ...
    • The Association Between Talc Use and Ovarian Cancer 

      Cramer, Daniel William; Vitonis, Allison F.; Terry, Kathryn Lynne; Welch, William Robert; Titus, Linda J. (Ovid Technologies (Wolters Kluwer Health), 2016)
      BACKGROUND: Multiple studies of ovarian cancer and genital talc use have led only to consensus about possible carcinogenicity. Seeking greater clarity, we examined this association in 2,041 cases with epithelial ovarian ...
    • The Association Between Talc Use and Ovarian Cancer: A Retrospective Case–Control Study in Two US States 

      Cramer, Daniel W.; Vitonis, Allison F.; Terry, Kathryn L.; Welch, William R.; Titus, Linda J. (Lippincott Williams & Wilkins, 2015)
      Background: Multiple studies of ovarian cancer and genital talc use have led only to consensus about possible carcinogenicity. Seeking greater clarity, we examined this association in 2,041 cases with epithelial ovarian ...
    • Association of Hexachlorobenzene (HCB), Dichlorodiphenyltrichloroethane (DDT), and Dichlorodiphenyldichloroethylene (DDE) with in Vitro Fertilization (IVF) Outcomes 

      Mahalingaiah, Shruthi; Maity, Arnab; Meeker, John D.; Berry, Katharine; Missmer, Stacey Ann; Williams, Paige L.; Ehrlich, Shelley; Perry, Melissa J.; Cramer, Daniel William; Hauser, Russ B. (National Institute of Environmental Health Sciences, 2012)
      Background: Hexachlorobenzene (HCB), dichlorodiphenyltrichloroethane (DDT), and dichlorodiphenyldichloroethylene (DDE) are persistent chlorinated pesticides with endocrine activity that may adversely affect the early stages ...
    • Autoantibody profiling to identify biomarkers of key pathogenic pathways in mucinous ovarian cancer 

      Tang, Liangdan; Yang, Junzheng; Ng, Shu-Kay; Rodriguez, Noah; Choi, Pui-Wah; Vitonis, Allison; Wang, Kui; McLachlan, Geoffrey J.; Caiazzo, Robert J.; Liu, Brian C.-S.; Welch, William Robert; Cramer, Daniel William; Berkowitz, Ross Stuart; Ng, Shu-Wing (Elsevier BV, 2010)
      Mucinous epithelial ovarian cancers are clinically and morphologically distinct from the other histopathologic subtypes of ovarian cancer. Unlike other ovarian subtypes, epidemiologic studies have indicated that tobacco ...
    • Autoantibody Signature for the Serologic Detection of Ovarian Cancer 

      Anderson, Karen S.; Cramer, Daniel W.; Sibani, Sahar; Wallstrom, Garrick; Wong, Jessica; Park, Jin; Qiu, Ji; Vitonis, Allison; LaBaer, Joshua (American Chemical Society, 2014)
      Sera from patients with ovarian cancer contain autoantibodies (AAb) to tumor-derived proteins that are potential biomarkers for early detection. To detect AAb, we probed high-density programmable protein microarrays (NAPPA) ...
    • Breast cancer susceptibility alleles and ovarian cancer risk in 2 study populations 

      Gates, Margaret A.; Tworoger, Shelley Slate; Terry, Kathryn Lynne; De Vivo, Immaculata; Hunter, David J.; Hankinson, Susan Elizabeth; Cramer, Daniel William (Wiley-Blackwell, 2009)
      Recent genome-wide scans identified several novel breast cancer risk alleles, including variants of the FGFR2, MAP3K1, and LSP1 genes, and a study of associations between these alleles and characteristics of breast cancer ...
    • Breast-feeding the last born child and risk of ovarian cancer 

      Titus-Ernstoff, Linda; Rees, Judy R.; Terry, Kathryn Lynne; Cramer, Daniel William (Springer Science + Business Media, 2009)
      Conflicting reports regarding the relationship between breast-feeding and ovarian cancer risk suggest a possible influence of patterns of breast-feeding. We used logistic regression to examine breast-feeding in a large ...
    • CA125 Immune Complexes in Ovarian Cancer Patients with Low CA125 Concentrations 

      Cramer, Daniel William; O'Rourke, D. J.; Vitonis, A. F.; Matulonis, Ursula Anne; DiJohnson, D. A.; Sluss, Patrick M.; Crum, Christopher Paul; Liu, B. C.- S. (American Association for Clinical Chemistry (AACC), 2010)
      BACKGROUND About 20% of women with ovarian cancer have low concentrations of serum cancer antigen 125 (CA125), and this important tumor marker cannot be used to monitor their disease. The measured concentration for mucin ...