Browsing by Author "Tchaicha, Jeremy"

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    • Loss of Lkb1 and Pten Leads to Lung Squamous Cell Carcinoma with Elevated PD-L1 Expression 

      Xu, Chunxiao; Fillmore, Christine M.; Koyama, Shohei; Hongbo, Wu; Zhao, Yanqiu; Chen, Zhao; Herter Sprie, Grit; Akbay, Esra A.; Tchaicha, Jeremy; Altabef, Abigail; Reibel, Jacob; Walton, Zandra; Ji, Hongbin; Watanabe, Hideo; Janne, Pasi; Castrillon, Diego H.; Rustgi, Anil K.; Bass, Adam; Freeman, Gordon; Padera, Robert; Dranoff, Glenn; Hammerman, Peter S.; Kim, Carla F.; Wong, Kwok-Kin; Hammerman (Elsevier BV, 2014-05)
      Lung squamous cell carcinoma (SCC) is a deadly disease for which current treatments are inadequate. We demonstrate that biallelic inactivation of Lkb1 and Pten in the mouse lung leads to SCC that recapitulates the histology, ...