Now showing items 1-4 of 4

    • Draft Genome Sequences of Two Extensively Drug-Resistant Strains of Mycobacterium tuberculosis Belonging to the Euro-American S Lineage 

      Malinga, Lesibana A.; Abeel, Thomas; Desjardins, Christopher A.; Dlamini, Talent C.; Cassell, Gail; Chapman, Sinéad B.; Birren, Bruce W.; Earl, Ashlee M.; van der Walt, Martie (American Society for Microbiology, 2016)
      We report the whole-genome sequencing of two extensively drug-resistant tuberculosis strains belonging to the Euro-American S lineage. The RSA 114 strain showed single-nucleotide polymorphisms predicted to have drug efflux ...
    • Evidence of Extensive DNA Transfer between Bacteroidales Species within the Human Gut 

      Coyne, Michael J.; Zitomersky, Naamah Levy; McGuire, Abigail Manson; Earl, Ashlee M.; Comstock, Laurie E. (American Society of Microbiology, 2014)
      ABSTRACT The genome sequences of intestinal Bacteroidales strains reveal evidence of extensive horizontal gene transfer. In vitro studies of Bacteroides and other bacteria have addressed mechanisms of conjugative transfer ...
    • Evolution of Extensively Drug-Resistant Tuberculosis over Four Decades: Whole Genome Sequencing and Dating Analysis of Mycobacterium tuberculosis Isolates from KwaZulu-Natal 

      Cohen, Keira A.; Abeel, Thomas; Manson McGuire, Abigail; Desjardins, Christopher A.; Munsamy, Vanisha; Shea, Terrance P.; Walker, Bruce J.; Bantubani, Nonkqubela; Almeida, Deepak V.; Alvarado, Lucia; Chapman, Sinéad B.; Mvelase, Nomonde R.; Duffy, Eamon Y.; Fitzgerald, Michael G.; Govender, Pamla; Gujja, Sharvari; Hamilton, Susanna; Howarth, Clinton; Larimer, Jeffrey D.; Maharaj, Kashmeel; Pearson, Matthew D.; Priest, Margaret E.; Zeng, Qiandong; Padayatchi, Nesri; Grosset, Jacques; Young, Sarah K.; Wortman, Jennifer; Mlisana, Koleka P.; O'Donnell, Max R.; Birren, Bruce W.; Bishai, William R.; Pym, Alexander S.; Earl, Ashlee M. (Public Library of Science, 2015)
      Background: The continued advance of antibiotic resistance threatens the treatment and control of many infectious diseases. This is exemplified by the largest global outbreak of extensively drug-resistant (XDR) tuberculosis ...
    • Genomic and functional analyses of Mycobacterium tuberculosis strains implicate ald in D-cycloserine resistance 

      Desjardins, Christopher A.; Cohen, Keira A.; Munsamy, Vanisha; Abeel, Thomas; Maharaj, Kashmeel; Walker, Bruce J.; Shea, Terrance P.; Almeida, Deepak V.; Manson, Abigail L.; Salazar, Alex; Padayatchi, Nesri; O’Donnell, Max R.; Mlisana, Koleka P.; Wortman, Jennifer; Birren, Bruce W.; Grosset, Jacques; Earl, Ashlee M.; Pym, Alexander S. (2016)
      A more complete understanding of the genetic basis of drug resistance in Mycobacterium tuberculosis is critical for prompt diagnosis and optimal treatment, particularly for toxic second-line drugs like D-cycloserine. Here, ...