Now showing items 1-3 of 3

    • Distortions in Genealogies due to Purifying Selection 

      Nicolaisen, Lauren Elisabeth (2014-06-06)
      As deleterious variants continually arise in a population, they tend to be purged via purifying selection, leading to distortions in the shapes of genealogies relative to neutral expectations. In recent years, a mounting ...
    • The Structure of Allelic Diversity in the Presence of Purifying Selection 

      Desai, Michael M; Nicolaisen, Lauren Elisabeth; Walczak, Aleksandra M.; Plotkin, Joshua B. (Elsevier, 2012)
      In the absence of selection, the structure of equilibrium allelic diversity is described by the elegant sampling formula of Ewens. This formula has helped shape our expectations of empirical patterns of molecular variation. ...
    • The Structure of Genealogies in the Presence of Purifying Selection: a "Fitness-Class Coalescent" 

      Walczak, Aleksandra M.; Nicolaisen, Lauren Elisabeth; Plotkin, Joshua B.; Desai, Michael M (Genetics Society of America, 2012)
      Compared to a neutral model, purifying selection distorts the structure of genealogies and hence alters the patterns of sampled genetic variation. Although these distortions may be common in nature, our understanding of ...