Browsing by Author "Bhan, Atul"

Now showing items 1-4 of 4

    • A combination of an anti-SLAMF6 antibody and ibrutinib efficiently abrogates expansion of chronic lymphocytic leukemia cells 

      Yigit, Burcu; Halibozek, Peter J.; Chen, Shih-Shih; O'Keeffe, Michael S.; Arnason, Jon; Avigan, David; Gattei, Valter; Bhan, Atul; Cen, Osman; Longnecker, Richard; Chiorazzi, Nicholas; Wang, Ninghai; Engel, Pablo; Terhorst, Cox (Impact Journals LLC, 2016)
      The signaling lymphocyte activation molecule family [SLAMF] of cell surface receptors partakes in both the development of several immunocyte lineages and innate and adaptive immune responses in humans and mice. For instance, ...

    • The kinase DYRK1A reciprocally regulates the differentiation of Th17 and regulatory T cells 

      Khor, Bernard; Gagnon, John D; Goel, Gautam; Roche, Marly I; Conway, Kara L; Tran, Khoa; Aldrich, Leslie N; Sundberg, Thomas B; Paterson, Alison M; Mordecai, Scott; Dombkowski, David; Schirmer, Melanie; Tan, Pauline H; Bhan, Atul K; Roychoudhuri, Rahul; Restifo, Nicholas P; O'Shea, John J; Medoff, Benjamin D; Shamji, Alykhan F; Schreiber, Stuart L; Sharpe, Arlene H; Shaw, Stanley Y; Xavier, Ramnik J (eLife Sciences Publications, Ltd, 2015)
      The balance between Th17 and T regulatory (Treg) cells critically modulates immune homeostasis, with an inadequate Treg response contributing to inflammatory disease. Using an unbiased chemical biology approach, we identified ...

    • mTORC1 in the Paneth Cell Niche Couples Intestinal Stem Cell Function to Calorie Intake 

      Katajisto, Pekka; Lamming, Dudley W.; Gültekin, Yetis; Bauer-Rowe, Khristian E.; Sengupta, Shomit; Birsoy, Kivanc; Dursun, Abdulmetin; Yilmaz, V. Onur; Selig, Martin; Nielson, G. Petur; Sabatini, David M.; Yilmaz, Omer Hidir; Mino-Kenudson, Mari; Zukerberg, Lawrence R.; Bhan, Atul Kumar; Deshpande, Vikram (Nature Publishing Group, 2012)
      How adult tissue stem and niche cells respond to the nutritional state of an organism is not well understood. Here we find that Paneth cells, a key constituent of the mammalian intestinal stem-cell (ISC) niche, augment ...

    • A unique B2 B cell subset in the intestine 

      Shimomura, Yasuyo; Ogawa, Atsuhiro; Kawada, Mayumi; Sugimoto, Ken; Mizoguchi, Atsushi; Shi, Hai-Ning; Pillai, Shiv Subramaniam; Bhan, Atul Kumar (The Rockefeller University Press, 2008)
      Over 80% of the body's activated B cells are located in mucosal sites, including the intestine. The intestine contains IgM[super]+ B cells, but these cells have not been characterized phenotypically or in terms of their ...