Now showing items 1-7 of 7

    • Altered ratios of pro‐ and anti‐angiogenic VEGF‐A variants and pericyte expression of DLL4 disrupt vascular maturation in infantile haemangioma 

      Ye, Xi; Abou‐Rayyah, Yassir; Bischoff, Joyce; Ritchie, Alison; Sebire, Neil J; Watts, Patrick; Churchill, Amanda J; Bates, David O (John Wiley & Sons, Ltd, 2016)
      Abstract Infantile haemangioma (IH), the most common neoplasm in infants, is a slowly resolving vascular tumour. Vascular endothelial growth factor A (VEGF‐A), which consists of both the pro‐ and anti‐angiogenic variants, ...
    • Cellular Targets of Propranolol in Infantile Hemangioma 

      Lee, Daniel K (2014-02-25)
      Infantile hemangioma (IH) is a vascular neoplasm that affects 4-10 percent of infants. Propranolol, a non-selective beta-adrenergic receptor (AR) antagonist, was serendipitously discovered to accelerate regression of IH ...
    • Cyclic Strain Induces Dual-Mode Endothelial-Mesenchymal Transformation of the Cardiac Valve 

      Balachandran, Kartik; Alford, Patrick W.; Wylie-Sears, Jill; Goss, Josue; Grosberg, Anna; Bischoff, Joyce E.; Aikawa, Elena; Levine, Robert A.; Parker, Kevin Kit (Proceedings of the National Academy of Sciences, 2011)
      Endothelial-mesenchymal transformation (EMT) is a critical event for the embryonic morphogenesis of cardiac valves. Inducers of EMT during valvulogenesis include VEGF, TGF-β1, and wnt/β-catenin (where wnt refers to the ...
    • Endoglin regulates mural cell adhesion in the circulatory system 

      Rossi, Elisa; Smadja, David M.; Boscolo, Elisa; Langa, Carmen; Arevalo, Miguel A.; Pericacho, Miguel; Gamella-Pozuelo, Luis; Kauskot, Alexandre; Botella, Luisa M.; Gaussem, Pascale; Bischoff, Joyce; Lopez-Novoa, José M.; Bernabeu, Carmelo (Springer International Publishing, 2015)
      The circulatory system is walled off by different cell types, including vascular mural cells and podocytes. The interaction and interplay between endothelial cells (ECs) and mural cells, such as vascular smooth muscle cells ...
    • The GPR 55 agonist, L-α-lysophosphatidylinositol, mediates ovarian carcinoma cell-induced angiogenesis 

      Hofmann, Nicole A; Yang, Jiang; Trauger, Sunia A; Nakayama, Hironao; Huang, Lan; Strunk, Dirk; Moses, Marsha A; Klagsbrun, Michael; Bischoff, Joyce; Graier, Wolfgang F (John Wiley & Sons, Ltd, 2015)
      Background and Purpose Highly vascularized ovarian carcinoma secretes the putative endocannabinoid and GPR55 agonist, L-α-lysophosphatidylinositol (LPI), into the circulation. We aimed to assess the involvement of this ...
    • Neuropilin-1 functions as a VEGFR2 co-receptor to guide developmental angiogenesis independent of ligand binding 

      Gelfand, Maria V; Hagan, Nellwyn; Tata, Aleksandra; Oh, Won-Jong; Lacoste, Baptiste; Kang, Kyu-Tae; Kopycinska, Justyna; Bischoff, Joyce; Wang, Jia-Huai; Gu, Chenghua (eLife Sciences Publications, Ltd, 2014)
      During development, tissue repair, and tumor growth, most blood vessel networks are generated through angiogenesis. Vascular endothelial growth factor (VEGF) is a key regulator of this process and currently both VEGF and ...
    • Propranolol treatment of infantile hemangioma endothelial cells: A molecular analysis 

      STILES, JESSICA; AMAYA, CLARISSA; PHAM, ROBERT; ROWNTREE, REBECCA K.; LACAZE, MARY; MULNE, ARLYNN; BISCHOFF, JOYCE; KOKTA, VICTOR; BOUCHERON, LAURA E.; MITCHELL, DIANNE C.; BRYAN, BRAD A. (D.A. Spandidos, 2012)
      Infantile hemangiomas (IHs) are non-malignant, largely cutaneous vascular tumors affecting approximately 5–10% of children to varying degrees. During the first year of life, these tumors are strongly proliferative, reaching ...