Now showing items 1-8 of 8

    • Control of signaling-mediated clearance of apoptotic cells by the tumor suppressor p53 

      Yoon, K. W.; Byun, S.; Kwon, Eunjeong; Hwang, So-Young; Chu, Kiki; Hiraki, Masatsugu; Jo, Seung-Hee; Weins, Astrid; Hakroush, Samy; Cebulla, Angelika; Sykes, David Brian; Greka, Anna; Mundel, Peter; Fisher, David E.; Mandinova, Anna; Lee, Sam Whan (American Association for the Advancement of Science (AAAS), 2015)
      The inefficient clearance of dying cells can lead to abnormal immune responses, such as unresolved inflammation and autoimmune conditions. We show that tumor suppressor p53 controls signaling-mediated phagocytosis of ...
    • Deep Sequencing Analysis of Phage Libraries using Illumina Platform 

      Matochko, Wadim L.; Chu, Kiki; Jin, Bingjie; Lee, Sam Whan; Whitesides, George McClelland; Derda, Ratmir (Elsevier BV, 2012)
      This paper presents an analysis of phage-displayed libraries of peptides using Illumina. We describe steps for the preparation of short DNA fragments for deep sequencing and MatLab software for the analysis of the results. ...
    • Discovery of a Potent and Selective DDR1 Receptor Tyrosine Kinase Inhibitor 

      Kim, Hyung-Gu; Tan, Li; Weisberg, Ellen L.; Liu, Feiyang; Canning, Peter; Choi, Hwan Geun; Ezell, Scott A.; Wu, Hong; Zhao, Zheng; Wang, Jinhua; Mandinova, Anna; Griffin, James D.; Bullock, Alex N.; Liu, Qingsong; Lee, Sam W.; Gray, Nathanael S. (American Chemical Society, 2013)
      The DDR1 receptor tyrosine kinase is activated by matrix collagens and has been implicated in numerous cellular functions such as proliferation, differentiation, adhesion, migration, and invasion. Here we report the discovery ...
    • Identification of ROCK1 kinase as a critical regulator of Beclin1 mediated autophagy during metabolic stress 

      Gurkar, Aditi U.; Chu, Kiki; Raj, Lakshmi; Bouley, Richard; Lee, Seung-Hwan; Kim, Young-Bum; Dunn, Sandra E.; Mandinova, Anna; Lee, Sam W. (2013)
      The Ser/Thr Rho kinase 1 (ROCK1) is known to play major roles in a wide range of cellular activities, including those involved in tumor metastasis and apoptosis. Here we identify an indispensable function of ROCK1 in ...
    • Induced cancer stem-like cells as a model for biological screening and discovery of agents targeting phenotypic traits of cancer stem cell 

      Nishi, Mayuko; Akutsu, Hidenori; Kudoh, Ayumi; Kimura, Hirokazu; Yamamoto, Naoki; Umezawa, Akihiro; Lee, Sam W.; Ryo, Akihide (Impact Journals LLC, 2014)
      Cancer stem cells (CSCs) retain the capacity to propagate themselves through self-renewal and to produce heterogeneous lineages of cancer cells constituting the tumor. Novel drugs that target CSCs can potentially eliminate ...
    • Loss of p53 enhances the function of the endoplasmic reticulum through activation of the IRE1α/XBP1 pathway 

      Namba, Takushi; Chu, Kiki; Kodama, Rika; Byun, Sanguine; Yoon, Kyoung Wan; Hiraki, Masatsugu; Mandinova, Anna; Lee, Sam W. (Impact Journals LLC, 2015)
      Altered regulation of ER stress response has been implicated in a variety of human diseases, such as cancer and metabolic diseases. Excessive ER function contributes to malignant phenotypes, such as chemoresistance and ...
    • Rho-kinase Regulates Energy Balance by Targeting Hypothalamic Leptin Receptor Signaling 

      Huang, Hu; Kong, Dong; Byun, Kyung Hee; Ye, Chianping; Koda, Shuichi; Lee, Dae Ho; Oh, Byung-Chul; Lee, Sam Whan; Lee, Bonghee; Zabolotny, Janice M.; Kim, Min Seon; Bjørbæk, Christian; Lowell, Bradford Barr; Kim, Young-Bum (2012)
      Leptin regulates energy balance. However, knowledge of the critical intracellular transducers of leptin signaling remains incomplete. Here we report that Rho-kinase 1 (ROCK1) regulates leptin action on body weight homeostasis ...
    • Transcriptional Role of p53 in Interferon-Mediated Antiviral Immunity 

      Muñoz-Fontela, César; Macip, Salvador; Martínez-Sobrido, Luis; Brown, Lauren; Ashour, Joseph; García-Sastre, Adolfo; Lee, Sam Whan; Aaronson, Stuart A. (Rockefeller University Press, 2008)
      Tumor suppressor p53 is activated by several stimuli, including DNA damage and oncogenic stress. Previous studies (Takaoka, A., S. Hayakawa, H. Yanai, D. Stoiber, H. Negishi, H. Kikuchi, S. Sasaki, K. Imai, T. Shibue, K. ...