Now showing items 1-2 of 2

    • Species-Specific Activity of HIV-1 Vpu and Positive Selection of Tetherin Transmembrane Domain Variants 

      McNatt, Matthew W.; Zang, Trinity; Hatziioannou, Theodora; Bartlett, Mackenzie; Fofana, Ismael Farouck; Johnson, Welkin Eric; Neil, Stuart J. D.; Bieniasz, Paul D. (Public Library of Science, 2009)
      Tetherin/BST-2/CD317 is a recently identified antiviral protein that blocks the release of nascent retrovirus, and other virus, particles from infected cells. An HIV-1 accessory protein, Vpu, acts as an antagonist of ...
    • Species-Specific Activity of SIV Nef and HIV-1 Vpu in Overcoming Restriction by Tetherin/BST2 

      Jia, Bin; Serra-Moreno, Ruth; Neidermyer, William James; Rahmberg, Andrew; Mackey, John J.; Fofana, Ismael Farouck; Johnson, Welkin Eric; Westmoreland, Susan V.; Evans, David T. (Public Library of Science, 2009)
      Tetherin, also known as BST2, CD317 or HM1.24, was recently identified as an interferon-inducible host–cell factor that interferes with the detachment of virus particles from infected cells. HIV-1 overcomes this restriction ...