Now showing items 1-9 of 9

    • The Cdc42 inhibitor secramine B prevents cAMP-induced K+ conductance in intestinal epithelial cells 

      Pelish, Henry Efrem; Ciesla, William; Tanaka, Nori; Reddy, Krishna Podditur; Shair, Matthew David; Kirchhausen, Tomas Leopold; Lencer, Wayne Isaac (Elsevier BV, 2006)
      Cyclic AMP- (cAMP) and calcium-dependent agonists stimulate chloride secretion through the coordinated activation of distinct apical and basolateral membrane channels and ion transporters in mucosal epithelial cells. Defects ...
    • Formation of the Postmitotic Nuclear Envelope from Extended ER Cisternae Precedes Nuclear Pore Assembly 

      Lu, Lei; Ladinsky, Mark S.; Kirchhausen, Tomas Leopold (The Rockefeller University Press, 2011)
      During mitosis, the nuclear envelope merges with the endoplasmic reticulum (ER), and nuclear pore complexes are disassembled. In a current model for reassembly after mitosis, the nuclear envelope forms by a reshaping of ...
    • Regulation of ligand-independent notch signal through intracellular trafficking 

      Hori, Kazuya; Sen, Anindya Kumar; Kirchhausen, Tomas Leopold; Artavanis-Tsakonas, Spyros (Landes Bioscience, 2012)
      Notch signaling is an evolutionarily conserved mechanism that defines a key cell fate control mechanism in metazoans. Notch signaling relies on the surface interaction between the Notch receptor and membrane bound ligands ...
    • Release of cellular tension signals self-restorative ventral lamellipodia to heal barrier micro-wounds 

      Martinelli, Roberta; Kamei, Masataka; Sage, Peter T.; Massol, Ramiro; Varghese, Laya; Sciuto, Tracey; Toporsian, Mourad; Dvorak, Ann M.; Kirchhausen, Tomas; Springer, Timothy A.; Carman, Christopher V. (The Rockefeller University Press, 2013)
      Basic mechanisms by which cellular barriers sense and respond to integrity disruptions remain poorly understood. Despite its tenuous structure and constitutive exposure to disruptive strains, the vascular endothelium ...
    • The Small Molecule Dispergo Tubulates the Endoplasmic Reticulum and Inhibits Export 

      Lu, Lei; Hannoush, Rami N.; Goess, Brian C.; Varadarajan, Shankar; Shair, Matthew David; Kirchhausen, Tomas Leopold (American Society for Cell Biology, 2013)
      The mammalian endoplasmic reticulum (ER) is an organelle that maintains a complex, compartmentalized organization of interconnected cisternae and tubules while supporting a continuous flow of newly synthesized proteins and ...
    • Structural Correlates of Rotavirus Cell Entry 

      Abdelhakim, Aliaa H.; Salgado, Eric N.; Fu, Xiaofeng; Pasham, Mithun; Nicastro, Daniela; Kirchhausen, Tomas; Harrison, Stephen C. (Public Library of Science, 2014)
      Cell entry by non-enveloped viruses requires translocation into the cytosol of a macromolecular complex—for double-strand RNA viruses, a complete subviral particle. We have used live-cell fluorescence imaging to follow ...
    • Structure of Clathrin Coat with Bound Hsc70 and Auxilin: Mechanism of Hsc70-Facilitated Disassembly 

      Xing, Yi; Böcking, Till; Wolf, Matthias; Grigorieff, Nikolaus; Kirchhausen, Tomas Leopold; Harrison, Stephen C. (Nature Publishing Group, 2010)
      The chaperone Hsc70 drives the clathrin assembly–disassembly cycle forward by stimulating dissociation of a clathrin lattice. A J-domain containing co-chaperone, auxilin, associates with a freshly budded clathrin-coated ...
    • Superinfection exclusion is absent during acute Junin virus infection of Vero and A549 cells 

      Gaudin, Raphaël; Kirchhausen, Tomas (Nature Publishing Group, 2015)
      Many viruses have evolved strategies of so-called “superinfection exclusion” to prevent re-infection of a cell that the same virus has already infected. Although Old World arenavirus infection results in down-regulation ...
    • Synergy Between the ESCRT-III Complex and Deltex Defines a Ligand-Independent Notch Signal 

      Hori, Kazuya; Sen, Anindya Kumar; Kirchhausen, Tomas Leopold; Artavanis-Tsakonas, Spyros (The Rockefeller University Press, 2011)
      The Notch signaling pathway defines a conserved mechanism that regulates cell fate decisions in metazoans. Signaling is modulated by a broad and multifaceted genetic circuitry, including members of the endocytic machinery. ...