Now showing items 1-19 of 19

    • The Association of a SNP Upstream of INSIG2 with Body Mass Index is Reproduced in Several but Not All Cohorts 

      Emilsson, Valur; Hinney, Anke; Heid, Iris M; Zhu, Xiaofeng; Thorleifsson, Gudmar; Gunnarsdottir, Steinunn; Walters, G. Bragi; Thorsteinsdottir, Unnur; Kong, Augustine; Gulcher, Jeffrey; Nguyen, Thuy Trang; Scherag, André; Pfeufer, Arne; Meitinger, Thomas; Brönner, Günter; Rief, Winfried; Soto-Quiros, Manuel E; Avila, Lydiana; Groop, Leif; Tuomi, Tiinamaija; Isomaa, Bo; Bengtsson, Kristina; Butler, Johannah L; Vollmert, Caren; Celedón, Juan C; Wichmann, H. Erich; Hebebrand, Johannes; Stefansson, Kari; Abecasis, Gonçalo; Lyon, Helen N; Su, Jessica Ann Lasky; Klanderman, Barbara Jordan; Raby, Benjamin Alexander; Silverman, Edwin Kepner; Weiss, Scott Tillman; Laird, Nan M.; Ding, Xiao; Cooper, Richard S; Fox, Caroline; O'Donnell, Christopher Joseph; Lange, Christoph; Hirschhorn, Joel Naom (Public Library of Science, 2007)
      A SNP upstream of the INSIG2 gene, rs7566605, was recently found to be associated with obesity as measured by body mass index (BMI) by Herbert and colleagues. The association between increased BMI and homozygosity for the ...
    • Asthma-susceptibility variants identified using probands in case-control and family-based analyses 

      Murphy, Amy J; Soto-Quiros, Manuel E; Avila, Lydiana; Celedón, Juan C; O'Connor, George T; Himes, Blanca Elena; Su, Jessica Ann Lasky; Wu, Ann Chen; Wilk, Jemma B; Hunninghake, Gary Matthew; Klanderman, Barbara Jordan; Lazarus, Ross; Lange, Christoph; Raby, Benjamin Alexander; Silverman, Edwin Kepner; Weiss, Scott Tillman (BioMed Central, 2010)
      Background: Asthma is a chronic respiratory disease whose genetic basis has been explored for over two decades, most recently via genome-wide association studies. We sought to find asthma-susceptibility variants by using ...
    • Comparison of Linkage and Association Strategies for Quantitative Traits Using the COGA Dataset 

      McQueen, Matthew B; Murphy, Amy; Kraft, Peter; Su, Jessica Ann Lasky; Lazarus, Ross; Laird, Nan M.; Lange, Christoph; Van Steen, Kristel (BioMed Central, 2005)
      Genome scans using dense single-nucleotide polymorphism (SNP) data have recently become a reality. It is thought that the increase in information content for linkage analysis as a result of the denser scans will help refine ...
    • Comprehensive Genetic Assessment of a Functional TLR9 Promoter Polymorphism: No Replicable Association with Asthma or Asthma-Related Phenotypes 

      Avila, Lydiana; Hawrylowicz, Catherine M; Lange, Nancy Elizabeth; Zhou, Xiaobo; Su, Jessica Ann Lasky; Himes, Blanca Elena; Lazarus, Ross; Raby, Benjamin Alexander; Litonjua, Augusto Ampil; Soto-Quiros, Manuel; Celedon, Juan C (BioMed Central, 2011)
      Background: Prior studies suggest a role for a variant (rs5743836) in the promoter of toll-like receptor 9 (TLR9) in asthma and other inflammatory diseases. We performed detailed genetic association studies of the functional ...
    • Effects of Endotoxin Exposure on Childhood Asthma Risk are Modified by a Genetic Polymorphism in ACAA1 

      Sordillo, Joanne; Sharma, Sunita; Poon, Audrey; Su, Jessica Ann Lasky; Belanger, Kathleen; Milton, Donald Kirby; Bracken, Michael B; Triche, Elizabeth W; Leaderer, Brian P; Gold, Diane R.; Litonjua, Augusto Ampil (BioMed Central, 2011)
      Background: Polymorphisms in the endotoxin-mediated TLR4 pathway genes have been associated with asthma and atopy. We aimed to examine how genetic polymorphisms in innate immunity pathways interact with endotoxin to influence ...
    • Genome-Wide Association Analysis in Asthma Subjects Identifies SPATS2L as a Novel Bronchodilator Response Gene 

      Himes, Blanca Elena; Jiang, Xiaofeng; Hu, Ruoxi; Wu, Ann Chen; Su, Jessica Ann Lasky; Klanderman, Barbara J.; Ziniti, John; Senter-Sylvia, Jody; Lima, John J.; Irvin, Charles G.; Peters, Stephen P.; Meyers, Deborah A.; Bleecker, Eugene R.; Kubo, Michiaki; Tamari, Mayumi; Nakamura, Yusuke; Szefler, Stanley J.; Lemanske, Robert F.; Zeiger, Robert S.; Strunk, Robert C.; Martinez, Fernando D.; Hanrahan, John P.; Koppelman, Gerard H.; Postma, Dirkje S.; Nieuwenhuis, Maartje A. E.; Vonk, Judith M.; Panettieri, Reynold A.; Markezich, Amy; Israel, Elliot; Carey, Vincent James; Tantisira, Kelan; Litonjua, Augusto Ampil; Lu, Quan; Weiss, Scott Tillman (Public Library of Science, 2012)
      Bronchodilator response (BDR) is an important asthma phenotype that measures reversibility of airway obstruction by comparing lung function (i.e. FEV1) before and after the administration of a short-acting β2-agonist, the ...
    • A genome-wide association study of bronchodilator response in asthmatics 

      Duan, Q; Lasky-Su, Jessica A. Lasky; Himes, Blanca; Qiu, Weiliang; Litonjua, Augusto Ampil; Damask, Amy; Lazarus, Richard James; Klanderman, Barbara; Irvin, Charles G.; Peters, Stephen P; Hanrahan, John P; Lima, John J.; Martinez, Fernando D.; Mauger, David; Chinchilli, Vernon M.; Soto-Quiros, Manuel; Avila, Lydiana; Celedón, Juan C.; Lange, Christoph; Weiss, Scott Tillman; Tantisira, Kelan (Nature Publishing Group, 2013)
      Reversibility of airway obstruction in response to β2-agonists is highly variable among asthmatics, which is partially attributed to genetic factors. In a genome-wide association study of acute bronchodilator response (BDR) ...
    • Genome-wide association study of the age of onset of childhood asthma 

      Forno, Erick; Lasky-Su, Jessica A. Lasky; Himes, Blanca; Howrylak, Judie; Ramsey, Clare; Brehm, John; Klanderman, Barbara; Ziniti, John; Melén, Erik; Pershagen, Goran; Wickman, Magnus; Martinez, Fernando; Mauger, Dave; Sorkness, Christine; Tantisira, Kelan; Raby, Benjamin Alexander; Weiss, Scott Tillman; Celedón, Juan C. (Elsevier BV, 2012)
      BACKGROUND: Childhood asthma is a complex disease with known heritability and phenotypic diversity. Although an earlier onset has been associated with more severe disease, there has been no genome-wide association study ...
    • Genome-wide association study reveals class I MHC–restricted T cell–associated molecule gene (CRTAM) variants interact with vitamin D levels to affect asthma exacerbations 

      Du, Rose; Litonjua, Augusto Ampil; Tantisira, Kelan; Lasky-Su, Jessica A. Lasky; Sunyaev, Shamil R.; Klanderman, Barbara; Celedón, Juan C.; Avila, Lydiana; Soto-Quiros, Manuel E.; Weiss, Scott Tillman (Elsevier BV, 2012)
      Background— It has recently been shown that vitamin D deficiency can increase asthma development and severity and that variations in vitamin D receptor genes are associated with asthma susceptibility. Objective— We sought ...
    • Genomewide association between GLCCI1 and response to glucocorticoid therapy in asthma 

      Tantisira, Kelan; Lasky-Su, Jessica A. Lasky; Harada, Michishige; Murphy, Amy; Litonjua, Augusto Ampil; Himes, Blanca; Lange, Christoph; Lazarus, Ross; Sylvia, Jody; Klanderman, Barbara; Duan, Qing Ling; Qiu, Weiliang; Hirota, Tomomitsu; Martinez, Fernando D.; Mauger, David; Sorkness, Christine; Szefler, Stanley; Lazarus, Stephen C.; Lemanske, Robert F.; Peters, Stephen P.; Lima, John J.; Nakamura, Yusuke; Tamari, Mayumi; Weiss, Scott Tillman (New England Journal of Medicine (NEJM/MMS), 2011)
      Background: The response to treatment for asthma is characterized by wide interindividual variability, with a significant number of patients who have no response. We hypothesized that a genomewide association study would ...
    • Genomic Screening in Family-Based Association Testing 

      Murphy, Amy; McQueen, Matthew B; Su, Jessica Ann Lasky; Kraft, Peter; Lazarus, Ross; Laird, Nan M.; Lange, Christoph; Van Steen, Kristel (BioMed Central, 2005)
      Due to the recent gains in the availability of single-nucleotide polymorphism data, genome-wide association testing has become feasible. It is hoped that this additional data may confirm the presence of disease susceptibility ...
    • Importin-13 genetic variation is associated with improved airway responsiveness in childhood asthma 

      Raby, Benjamin Alexander; Van Steen, Kristel; Su, Jessica Ann Lasky; Tantisira, Kelan; Kaplan, Feige; Weiss, Scott Tillman (BioMed Central, 2009)
      Background: Glucocorticoid function is dependent on efficient translocation of the glucocorticoid receptor (GR) from the cytoplasm to the nucleus of cells. Importin-13 (IPO13) is a nuclear transport receptor that mediates ...
    • Inhaled corticosteroid treatment modulates ZNF432 gene variant’s effect on bronchodilator response in asthmatics 

      Wu, Ann Chen; Himes, Blanca; Lasky-Su, Jessica A. Lasky; Litonjua, Augusto Ampil; Peters, Stephen P.; Lima, John; Kubo, Michiaki; Tamari, Mayumi; Nakamura, Yusuke; Qiu, Weiliang; Weiss, Scott Tillman; Tantisira, Kelan (Elsevier BV, 2014)
      Background: Single nucleotide polymorphisms (SNPs) influence a patient's response to inhaled corticosteroids and β2-agonists, and the effect of treatment with inhaled corticosteroids is synergistic with the effect of ...
    • Integrated genome-wide association, coexpression network, and expression single nucleotide polymorphism analysis identifies novel pathway in allergic rhinitis 

      Bunyavanich, Supinda; Schadt, Eric E; Himes, Blanca E; Lasky-Su, Jessica; Qiu, Weiliang; Lazarus, Ross; Ziniti, John P; Cohain, Ariella; Linderman, Michael; Torgerson, Dara G; Eng, Celeste S; Pino-Yanes, Maria; Padhukasahasram, Badri; Yang, James J; Mathias, Rasika A; Beaty, Terri H; Li, Xingnan; Graves, Penelope; Romieu, Isabelle; Navarro, Blanca del Rio; Salam, M Towhid; Vora, Hita; Nicolae, Dan L; Ober, Carole; Martinez, Fernando D; Bleecker, Eugene R; Meyers, Deborah A; Gauderman, W James; Gilliland, Frank; Burchard, Esteban G; Barnes, Kathleen C; Williams, L Keoki; London, Stephanie J; Zhang, Bin; Raby, Benjamin A; Weiss, Scott T (BioMed Central, 2014)
      Background: Allergic rhinitis is a common disease whose genetic basis is incompletely explained. We report an integrated genomic analysis of allergic rhinitis. Methods: We performed genome wide association studies (GWAS) ...
    • Joint GWAS Analysis: Comparing similar GWAS at different genomic resolutions identifies novel pathway associations with six complex diseases 

      McGeachie, Michael John; Clemmer, George L.; Lasky-Su, Jessica A. Lasky; Dahlin, Amber Aziza; Raby, Benjamin Alexander; Weiss, Scott Tillman (Elsevier BV, 2014)
      We show here that combining two existing genome wide association studies (GWAS) yields additional biologically relevant information, beyond that obtained by either GWAS separately. We propose Joint GWAS Analysis, a method ...
    • The metabolomics of asthma control: a promising link between genetics and disease 

      McGeachie, Michael J; Dahlin, Amber; Qiu, Weiliang; Croteau-Chonka, Damien C; Savage, Jessica; Wu, Ann Chen; Wan, Emily S; Sordillo, Joanne E; Al-Garawi, Amal; Martinez, Fernando D; Strunk, Robert C; Lemanske, Robert F; Liu, Andrew H; Raby, Benjamin A; Weiss, Scott; Clish, Clary B; Lasky-Su, Jessica A (John Wiley & Sons, Ltd, 2015)
      Short-acting β agonists (e.g., albuterol) are the most commonly used medications for asthma, a disease that affects over 300 million people in the world. Metabolomic profiling of asthmatics taking β agonists presents a new ...
    • Polymorphisms in IL12A and Cockroach Allergy in Children with Asthma 

      Pistiner, Michael; Hunninghake, Gary Matthew; Soto-Quiros, Manuel E; Avila, Lydiana; Murphy, Amy; Su, Jessica Ann Lasky; Schuemann, Brooke; Klanderman, Barbara Jordan; Raby, Benjamin Alexander; Celedón, Juan C (BioMed Central, 2008)
      Background: IL12A has been implicated in T-cell development and may thus influence the development of atopy and allergic diseases. Methods: We tested for association between four linkage disequilibrium (LD)-tagging SNPs ...
    • RNA-Seq Transcriptome Profiling Identifies CRISPLD2 as a Glucocorticoid Responsive Gene that Modulates Cytokine Function in Airway Smooth Muscle Cells 

      Himes, Blanca E.; Jiang, Xiaofeng; Wagner, Peter; Hu, Ruoxi; Wang, Qiyu; Klanderman, Barbara; Whitaker, Reid M.; Duan, Qingling; Lasky-Su, Jessica; Nikolos, Christina; Jester, William; Johnson, Martin; Panettieri, Reynold A.; Tantisira, Kelan G.; Weiss, Scott T.; Lu, Quan (Public Library of Science, 2014)
      Asthma is a chronic inflammatory respiratory disease that affects over 300 million people worldwide. Glucocorticoids are a mainstay therapy for asthma because they exert anti-inflammatory effects in multiple lung tissues, ...
    • A Twin Study of Early-Childhood Asthma in Puerto Ricans 

      Bunyavanich, Supinda; Silberg, Judy L.; Lasky-Su, Jessica; Gillespie, Nathan A.; Lange, Nancy E.; Canino, Glorisa; Celedόn, Juan C. (Public Library of Science, 2013)
      Background: The relative contributions of genetics and environment to asthma in Hispanics or to asthma in children younger than 3 years are not well understood. Objective: To examine the relative contributions of genetics ...