Now showing items 1-6 of 6

    • CD39 and Control of Cellular Immune Responses 

      Dwyer, Karen M.; Deaglio, Silvia; Gao, Wenda; Friedman, David J.; Strom, Terry Barton; Robson, Simon Christopher (Springer Verlag, 2007)
      CD39 is the cell surface-located prototypic member of the ecto-nucleoside triphosphate diphosphohydrolase (E-NTPDase) family. Biological actions of CD39 are a consequence (at least in part) of the regulated phosphohydrolytic ...
    • Contrasting Roles of Islet Resident Immunoregulatory Macrophages and Dendritic Cells in Experimental Autoimmune Type 1 Diabetes 

      Thornley, Thomas B.; Agarwal, Krishna A.; Kyriazis, Periklis; Ma, Lingzhi; Chipashvili, Vaja; Aker, Jonathan E.; Korniotis, Sarantis; Csizmadia, Eva; Strom, Terry B.; Koulmanda, Maria (Public Library of Science, 2016)
      The innate immune system critically shapes diabetogenic adaptive immunity during type 1 diabetes (T1D) pathogenesis. While the role of tissue-infiltrating monocyte-derived macrophages in T1D is well established, the role ...
    • Exogenous IFN-γ Ex Vivo Shapes the Alloreactive T-Cell Repertoire by Inhibition of Th17 Responses and Generation of Functional Foxp3+ Regulatory T Cells 

      Feng, Gang; Gao, Wenda; Strom, Terry Barton; Oukka, Mohamed; Francis, Ross S; Wood, Kathryn J; Bushell, Andrew (WILEY-VCH Verlag, 2008)
      Interferon (IFN)-γ was originally characterized as a pro-inflammatory cytokine with T helper type 1-inducing activity, but subsequent work has demonstrated that mice deficient in IFN-γ or IFN-γ receptor show exacerbated ...
    • Human CD4+ Memory T Cells Can Become CD4+IL-9+ T Cells 

      Putheti, Prabhakar; Awasthi, Amit; Popoola, Joyce; Gao, Wenda; Strom, Terry Barton (Public Library of Science, 2010)
      Background: IL-9 is a growth factor for T- and mast-cells that is secreted by human Th2 cells. We recently reported that IL-4+TGF-β directs mouse CD4+CD25−CD62L+ T cells to commit to inflammatory IL-9 producing CD4+ T ...
    • The Role of TNF-\(\alpha\) in Mice with Type 1- and 2- Diabetes 

      Bhasin, Manoj; Awdeh, Zuheir; Qipo, Andi; Putheti, Prabhakar; Shi, Hang; Csizuadia, Eva; Koulmanda, Maria; Fan, Zhigang; Hanidziar, Dusan; Libermann, Towia Aron; Strom, Terry Barton (Public Library of Science, 2012)
      Background: Previously, we have demonstrated that short-term treatment of new onset diabetic Non-obese diabetic (NOD) mice, mice that are afflicted with both type 1 (T1D) and type 2 (T2D) diabetes with either Power Mix ...
    • Tracking Single Cells in Live Animals Using a Photoconvertible Near-Infrared Cell Membrane Label 

      Carlson, Alicia L.; Fujisaki, Joji; Wu, Juwell; Runnels, Judith M.; Turcotte, Raphaël; Celso, Cristina Lo; Scadden, David T.; Strom, Terry B.; Lin, Charles P. (Public Library of Science, 2013)
      We describe a novel photoconversion technique to track individual cells in vivo using a commercial lipophilic membrane dye, DiR. We show that DiR exhibits a permanent fluorescence emission shift (photoconversion) after ...