Browsing by Author "Hooker, Christine"
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Adults with high social anhedonia have altered neural connectivity with ventral lateral prefrontal cortex when processing positive social signals
Yin, Hong; Tully, Laura M.; Lincoln, Sarah Hope; Hooker, Christine I. (Frontiers Media S.A., 2015)Social anhedonia (SA) is a debilitating characteristic of schizophrenia, a common feature in individuals at psychosis-risk, and a vulnerability for developing schizophrenia-spectrum disorders. Prior work (Hooker et al., ... -
Amygdala Response to Facial Expressions Reflects Emotional Learning
Hooker, Christine; Germine, Laura; Knight, Robert T.; D'Esposito, Mark (Society for Neuroscience, 2006)The functional role of the human amygdala in the evaluation of emotional facial expressions is unclear. Previous animal and human research shows that the amygdala participates in processing positive and negative reinforcement ... -
Attentional control mediates the relationship between social anhedonia and social impairment
Tully, Laura M.; Lincoln, Sarah Hope; Hooker, Christine I. (Frontiers Media S.A., 2014)Social anhedonia (SA), a trait-like disinterest in social contact and diminished capacity to experience pleasure from social interactions, is consistently associated with social impairments in both healthy and clinical ... -
Brain Networks for Analyzing Eye Gaze
Hooker, Christine; Paller, Ken A.; Gitelman, Darren R.; Parrish, Todd B.; Mesulam, M.-Marsel; Reber, Paul J. (Elsevier, 2003)The eyes convey a wealth of information in social interactions. This information is analyzed by multiple brain networks, which we identified using functional magnetic resonance imaging (MRI). Subjects attempted to detect ... -
Can I Trust You? Negative Affective Priming Influences Social Judgments in Schizophrenia
Hooker, Christine; Tully, Laura Magdalen; Verosky, Sara C.; Fisher, Melissa; Holland, Christine; Vinogradov, Sophia (American Psychological Association, 2011)Successful social interactions rely on the ability to make accurate judgments based on social cues as well as the ability to control the influence of internal or external affective information on those judgments. Prior ... -
Cognitive Control of Emotional Information in Schizophrenia: Understanding the Mechanisms of Social Functioning Impairments
Tully, Laura Magdalen (2013-10-18)Social functioning impairments are a core, debilitating, and treatment refractory feature of schizophrenia. The mechanisms contributing to these impairments are unknown. Cognitive control mechanisms, mediated by the lateral ... -
Emotion Processing and its Relationship to Social Functioning in Schizophrenia Patients
Hooker, Christine; Park, Sohee (Elsevier, 2002)Schizophrenia patients have demonstrated deficits in affect recognition. Whether this deficit is part of a general difficulty in face perception or a specific problem in affect recognition is debatable. However, there is ... -
Emotion Recognition and Psychosis-Proneness: Neural and Behavioral Perspectives
Germine, Laura Thi (2012-09-14)Schizophrenia is associated with deficits in social cognition and emotion processing, but it is not known how these deficits relate to other domains of neurocognition and whether they might contribute to psychosis development. ... -
Face Emotion Recognition is Related to Individual Differences in Psychosis-proneness
Germine, Laura Thi; Hooker, Christine (Cambridge University Press, 2010)Background Deficits in face emotion recognition (FER) in schizophrenia are well documented, and have been proposed as a potential intermediate phenotype for schizophrenia liability. However, research on the relationship ... -
The Influence of Personality on Neural Mechanisms of Observational Fear and Reward Learning
Hooker, Christine; D'Esposito, Mark; Knight, Robert T.; Miyakawa, Asako; Verosky, Sara C. (Elsevier, 2008)Fear and reward learning can occur through direct experience or observation. Both channels can enhance survival or create maladaptive behavior. We used fMRI to isolate neural mechanisms of observational fear and reward ... -
Lateral prefrontal cortex activity during cognitive control of emotion predicts response to social stress in schizophrenia
Tully, Laura M.; Lincoln, Sarah Hope; Hooker, Christine I. (Elsevier, 2014)LPFC dysfunction is a well-established neural impairment in schizophrenia and is associated with worse symptoms. However, how LPFC activation influences symptoms is unclear. Previous findings in healthy individuals demonstrate ... -
Mentalizing About Emotion and its Relationship to Empathy
Hooker, Christine; Verosky, Sara C.; Germine, Laura; Knight, Robert T.; D'Esposito, Mark (Oxford University Press, 2008)Mentalizing involves the ability to predict someone elses behavior based on their belief state. More advanced mentalizing skills involve integrating knowledge about beliefs with knowledge about the emotional impact of those ... -
Neural Activity During Social Signal Perception Correlates With Self-reported Empathy
Hooker, Christine; Verosky, Sara C.; Germine, Laura Thi; Knight, Robert T.; D'Esposito, Mark (Elsevier, 2010)Empathy is an important component of human relationships, yet the neural mechanisms that facilitate empathy are unclear. The broad construct of empathy incorporates both cognitive and affective components. Cognitive empathy ... -
Neural Activity to a Partner's Facial Expression Predicts Self-Regulation After Conflict
Hooker, Christine; Gyurak, Anett; Verosky, Sara; Miyakawa, Asako; Ayduk, Ozlem (Elsevier BV, 2010)Introduction: Failure to self-regulate after an interpersonal conflict can result in persistent negative mood and maladaptive behaviors. Research indicates that lateral prefrontal cortex (LPFC) activity is related to ... -
The Neural Basis of Social Cognition and Its Relationship to Social Functioning in Young People at Risk for Schizophrenia
Lincoln, Sarah Hope (2015-08-12)These three studies seek to contribute to the neurological characterization of the development of schizophrenia as well as begin to branch into understanding how neuroanatomical structure and function may relate to specific ... -
The neural basis of theory of mind and its relationship to social functioning and social anhedonia in individuals with schizophrenia☆
Dodell-Feder, David; Tully, Laura M.; Lincoln, Sarah Hope; Hooker, Christine I. (Elsevier, 2013)Theory of mind (ToM), the ability to attribute and reason about the mental states of others, is a strong determinant of social functioning among individuals with schizophrenia. Identifying the neural bases of ToM and their ... -
Neural Effects of the Social Environment
Krabbendam, Lydia; Hooker, Christine I.; Aleman, André (Oxford University Press, 2014)Epidemiological studies have suggested that the association between city upbringing and minority status with risk for schizophrenia can be explained by social mechanisms. Neuroimaging approaches hold promise for investigating ... -
Neural signal during immediate reward anticipation in schizophrenia: Relationship to real-world motivation and function
Subramaniam, Karuna; Hooker, Christine I.; Biagianti, Bruno; Fisher, Melissa; Nagarajan, Srikantan; Vinogradov, Sophia (Elsevier, 2015)Amotivation in schizophrenia is a central predictor of poor functioning, and is thought to occur due to deficits in anticipating future rewards, suggesting that impairments in anticipating pleasure can contribute to ... -
Randomized controlled trial of computer-based treatment of social cognition in schizophrenia: the TRuSST trial protocol
Rose, Annika; Vinogradov, Sophia; Fisher, Melissa; Green, Michael F.; Ventura, Joseph; Hooker, Christine; Merzenich, Michael; Nahum, Mor (BioMed Central, 2015)Background: Schizophrenia is a severe and chronic medical condition, characterized by positive and negative symptoms, as well as pervasive social cognitive deficits. Despite the functional significance of the social cognition ... -
Using Fiction to Assess Mental State Understanding: A New Task for Assessing Theory of Mind in Adults
Dodell-Feder, David; Lincoln, Sarah Hope; Coulson, Joseph P.; Hooker, Christine I. (Public Library of Science, 2013)Social functioning depends on the ability to attribute and reason about the mental states of others – an ability known as theory of mind (ToM). Research in this field is limited by the use of tasks in which ceiling effects ...