Now showing items 1-8 of 8

    • An Atlas of Genetic Correlations across Human Diseases and Traits 

      Bulik-Sullivan, Brendan; Finucane, Hilary K; Anttila, Verneri; Gusev, Alexander; Day, Felix R.; Loh, Po-Ru; Duncan, Laramie; Perry, John R.B.; Patterson, Nick; Robinson, Elise B.; Daly, Mark J.; Price, Alkes L.; Neale, Benjamin M. (2015)
      Identifying genetic correlations between complex traits and diseases can provide useful etiological insights and help prioritize likely causal relationships. The major challenges preventing estimation of genetic correlation ...
    • Contrasting genetic architectures of schizophrenia and other complex diseases using fast variance components analysis 

      Loh, Po-Ru; Bhatia, Gaurav; Gusev, Alexander; Finucane, Hilary K; Bulik-Sullivan, Brendan K; Pollack, Samuela J; de Candia, Teresa R; Lee, Sang Hong; Wray, Naomi R; Kendler, Kenneth S; O’Donovan, Michael C; Neale, Benjamin M; Patterson, Nick; Price, Alkes L (2015)
      Heritability analyses of GWAS cohorts have yielded important insights into complex disease architecture, and increasing sample sizes hold the promise of further discoveries. Here, we analyze the genetic architecture of ...
    • Deep targeted sequencing of 12 breast cancer susceptibility regions in 4611 women across four different ethnicities 

      Lindström, Sara; Ablorh, Akweley; Chapman, Brad; Gusev, Alexander; Chen, Gary; Turman, Constance; Eliassen, A. Heather; Price, Alkes L.; Henderson, Brian E.; Le Marchand, Loic; Hofmann, Oliver; Haiman, Christopher A.; Kraft, Peter (BioMed Central, 2016)
      Background: Although genome-wide association studies (GWASs) have identified thousands of disease susceptibility regions, the underlying causal mechanism in these regions is not fully known. It is likely that the GWAS ...
    • Extended haplotype association study in Crohn’s disease identifies a novel, Ashkenazi Jewish-specific missense mutation in the NF-κB pathway gene, HEATR3 

      Zhang, Wei; Hui, Ken Y.; Gusev, Alexander; Warner, Neil; Evelyn Ng, Sok Meng; Ferguson, John; Choi, Murim; Burberry, Aaron; Abraham, Clara; Mayer, Lloyd; Desnick, Robert J.; Cardinale, Christopher J.; Hakonarson, Hakon; Waterman, Matti; Chowers, Yehuda; Karban, Amir; Brant, Steven R.; Silverberg, Mark S.; Gregersen, Peter K.; Katz, Seymour; Lifton, Richard P.; Zhao, Hongyu; Nuñez, Gabriel; Pe’er, Itsik; Peter, Inga; Cho, Judy H. (2013)
      The Ashkenazi Jewish population has a several-fold higher prevalence of Crohn’s disease compared to non-Jewish European ancestry populations and has a unique genetic history. Haplotype association is critical to Crohn’s ...
    • Leveraging local ancestry to detect gene-gene interactions in genome-wide data 

      Aschard, Hugues; Gusev, Alexander; Brown, Robert; Pasaniuc, Bogdan (BioMed Central, 2015)
      Background: Although genome-wide association studies have successfully identified thousands of variants associated to complex traits, these variants only explain a small amount of the entire heritability of the trait. ...
    • Leveraging population admixture to explain missing heritability of complex traits 

      Zaitlen, Noah; Pasaniuc, Bogdan; Sankararaman, Sriram; Bhatia, Gaurav; Zhang, Jianqi; Gusev, Alexander; Young, Taylor; Tandon, Arti; Pollack, Samuela; Vilhjálmsson, Bjarni J.; Assimes, Themistocles L.; Berndt, Sonja I.; Blot, William J.; Chanock, Stephen; Franceschini, Nora; Goodman, Phyllis G.; He, Jing; Hennis, Anselm JM; Hsing, Ann; Ingles, Sue A.; Isaacs, William; Kittles, Rick A.; Klein, Eric A.; Lange, Leslie A.; Nemesure, Barbara; Patterson, Nick; Reich, David; Rybicki, Benjamin A.; Stanford, Janet L.; Stevens, Victoria L; Strom, Sara S.; Whitsel, Eric A; Witte, John S.; Xu, Jianfeng; Haiman, Christopher; Wilson, James G.; Kooperberg, Charles; Stram, Daniel; Reiner, Alex P.; Tang, Hua; Price, Alkes L. (2014)
      Despite recent progress on estimating the heritability explained by genotyped SNPs (hg2), a large gap between hg2 and estimates of total narrow-sense heritability (h2) remains. Explanations for this gap include rare variants, ...
    • Partitioning heritability by functional annotation using genome-wide association summary statistics 

      Finucane, Hilary K.; Bulik-Sullivan, Brendan; Gusev, Alexander; Trynka, Gosia; Reshef, Yakir; Loh, Po-Ru; Anttila, Verneri; Xu, Han; Zang, Chongzhi; Farh, Kyle; Ripke, Stephan; Day, Felix R.; Consortium, ReproGen; Purcell, Shaun; Stahl, Eli; Lindstrom, Sara; Perry, John R. B.; Okada, Yukinori; Raychaudhuri, Soumya; Daly, Mark; Patterson, Nick; Neale, Benjamin M.; Price, Alkes L. (2015)
      Recent work has demonstrated that some functional categories of the genome contribute disproportionately to the heritability of complex diseases. Here, we analyze a broad set of functional elements, including cell-type-specific ...
    • Quantifying Missing Heritability at Known GWAS Loci 

      Gusev, Alexander; Bhatia, Gaurav; Zaitlen, Noah; Vilhjalmsson, Bjarni J.; Diogo, Dorothée; Stahl, Eli A.; Gregersen, Peter K.; Worthington, Jane; Klareskog, Lars; Raychaudhuri, Soumya; Plenge, Robert M.; Pasaniuc, Bogdan; Price, Alkes L. (Public Library of Science, 2013)
      Recent work has shown that much of the missing heritability of complex traits can be resolved by estimates of heritability explained by all genotyped SNPs. However, it is currently unknown how much heritability is missing ...