Now showing items 1-6 of 6

    • Cystic Papillary Pattern in Pancreatic Ductal Adenocarcinoma 

      Kelly, Paul J.; Shinagare, Shweta; Sainani, Nisha I.; Hong, Xiao; Ferrone, Cristina Rosa; Yilmaz, Omer Hidir; Fernandez-Del Castillo, Carlos F.; Lauwers, Gregory Y.; Deshpande, Vikram (Ovid Technologies (Wolters Kluwer Health), 2012)
      INTRODUCTION: The prototypic pancreatic ductal adenocarcinoma shows small-caliber glands that are placed within an exuberant desmoplastic stromal reaction. A number of histologic patterns have been described, and the ...
    • Depletion of Rictor, an essential protein component of mTORC2, decreases male lifespan 

      Lamming, Dudley W; Mihaylova, Maria M; Katajisto, Pekka; Baar, Emma L; Yilmaz, Omer H; Hutchins, Amanda; Gultekin, Yetis; Gaither, Rachel; Sabatini, David M (BlackWell Publishing Ltd, 2014)
      Rapamycin, an inhibitor of the mechanistic target of rapamycin (mTOR), robustly extends the lifespan of model organisms including mice. We recently found that chronic treatment with rapamycin not only inhibits mTOR complex ...
    • High fat diet enhances stemness and tumorigenicity of intestinal progenitors 

      Beyaz, Semir; Mana, Miyeko D.; Roper, Jatin; Kedrin, Dmitriy; Saadatpour, Assieh; Hong, Sue-Jean; Bauer-Rowe, Khristian E.; Xifaras, Michael E.; Akkad, Adam; Arias, Erika; Pinello, Luca; Katz, Yarden; Shinagare, Shweta; Abu-Remaileh, Monther; Mihaylova, Maria M.; Lamming, Dudley W.; Dogum, Rizkullah; Guo, Guoji; Bell, George W.; Selig, Martin; Nielsen, G. Petur; Gupta, Nitin; Ferrone, Cristina R.; Deshpande, Vikram; Yuan, Guo-Cheng; Orkin, Stuart H.; Sabatini, David M.; Yilmaz, Ömer H. (2016)
      Little is known about how pro-obesity diets regulate tissue stem and progenitor cell function. Here we find that high fat diet (HFD)-induced obesity augments the numbers and function of Lgr5+ intestinal stem-cells (ISCs) ...
    • The histone demethylase UTX regulates the lineage-specific epigenetic program of invariant natural killer T cells 

      Beyaz, Semir; Kim, Ji Hyung; Pinello, Luca; Xifaras, Michael E; Hu, Yu; Huang, Jialiang; Kerenyi, Marc A; Das, Partha Pratim; Barnitz, R Anthony; Herault, Aurelie; Dogum, Rizkullah; Haining, William Nicholas; Yilmaz, Omer Hidir; Passegue, Emmanuelle; Yuan, Guo-Cheng; Orkin, Stuart Holland; Winau, Florian (Springer Nature, 2016)
    • mTORC1 in the Paneth Cell Niche Couples Intestinal Stem Cell Function to Calorie Intake 

      Katajisto, Pekka; Lamming, Dudley W.; Gültekin, Yetis; Bauer-Rowe, Khristian E.; Sengupta, Shomit; Birsoy, Kivanc; Dursun, Abdulmetin; Yilmaz, V. Onur; Selig, Martin; Nielson, G. Petur; Sabatini, David M.; Yilmaz, Omer Hidir; Mino-Kenudson, Mari; Zukerberg, Lawrence R.; Bhan, Atul Kumar; Deshpande, Vikram (Nature Publishing Group, 2012)
      How adult tissue stem and niche cells respond to the nutritional state of an organism is not well understood. Here we find that Paneth cells, a key constituent of the mammalian intestinal stem-cell (ISC) niche, augment ...
    • Peutz-Jeghers syndrome: a critical look at colonic Peutz-Jeghers polyps 

      Tse, Julie Yi; Wu, Shulin; Shinagare, Shweta A; Lauwers, Gregory Y.; Yilmaz, Omer Hidir; Wu, Chin-Lee; Deshpande, Vikram (Springer Nature, 2013)
      Peutz-Jeghers syndrome is an autosomal dominant condition characterized by gastrointestinal hamartomatous polyps. The pathologic identification of a Peutz-Jeghers polyp is integral to the diagnosis of this syndrome that ...