Now showing items 1-10 of 10

    • Chemical Substructures That Enrich for Biological Activity 

      Klekota, Justin; Roth, Frederick Phillip (Oxford University Press, 2008)
      Motivation: Certain chemical substructures are present in many drugs. This has led to the claim of ‘privileged’ substructures which are predisposed to bioactivity. Because bias in screening library construction could explain ...
    • An en masse Phenotype and Function Prediction System for Mus musculus 

      Taşan, Murat; Tian, Weidong; Hill, David; Gibbons, Francis D; Blake, Judith A; Roth, Frederick Phillip (BioMed Central, 2008)
      Background: Individual researchers are struggling to keep up with the accelerating emergence of high-throughput biological data, and to extract information that relates to their specific questions. Integration of accumulated ...
    • Interpreting Cancer Genomes Using Systematic Host Perturbations by Tumour Virus Proteins 

      Rozenblatt-Rosen, Orit; Deo, Rahul C.; Dricot, Amélie; Askenazi, Manor; Tavares, Maria; Abderazzaq, Fieda; Byrdsong, Danielle; Correll, Mick; Fan, Changyu; Feltkamp, Mariet C.; Franchi, Rachel; Garg, Brijesh K.; Gulbahce, Natali; Hao, Tong; Korkhin, Anna; Litovchick, Larisa; Mar, Jessica C.; Pak, Theodore R.; Rabello, Sabrina; Rubio, Renee; Shen, Yun; Tasan, Murat; Wanamaker, Shelly; Roecklein-Canfield, Jennifer; Johannsen, Eric; Barabási, Albert-László; Padi, Megha; Adelmant, Guillaume; Calderwood, Michael A; Rolland, Thomas; Grace, Miranda; Pevzner, Samuel; Carvunis, Anne-Ruxandra; Chen, Alyce Aura; Cheng, Jingwei; Duarte, Melissa; Ficarro, Scott; Holthaus, Amy Marie; James, Robert; Singh, Saurav; Spangle, Jennifer Marie; Webber, James T.; Beroukhim, Rameen; Kieff, Elliott D.; Cusick, Michael; Hill, David E.; Munger, Karl; Marto, Jarrod; Quackenbush, John; Roth, Frederick Phillip; DeCaprio, James A.; Vidal, Marc (Nature Publishing Group, 2012)
      Genotypic differences greatly influence susceptibility and resistance to disease. Understanding genotype-phenotype relationships requires that phenotypes be viewed as manifestations of network properties, rather than simply ...
    • Interpreting Metabolomic Profiles using Unbiased Pathway Models 

      Hunter, Luke; Pare, Guillaume; Vasan, Ramachandran S.; Lewis, Gregory D; Wang, Thomas Jue-Fuu; Chasman, Daniel Ian; Gerszten, Robert Edgardo; Deo, Rahul Chandrakant; Roth, Frederick Phillip (Public Library of Science, 2010)
      Human disease is heterogeneous, with similar disease phenotypes resulting from distinct combinations of genetic and environmental factors. Small-molecule profiling can address disease heterogeneity by evaluating the ...
    • Q&A: Epistasis 

      Roth, Frederick Phillip; Lipshitz, Howard D; Andrews, Brenda J (BioMed Central, 2009)
    • A Race through the Maze of Genomic Evidence 

      Hughes, Timothy R; Roth, Frederick Phillip (BioMed Central, 2008)
    • RanBP2/Nup358 Potentiates the Translation of a Subset of mRNAs Encoding Secretory Proteins 

      Mahadevan, Kohila; Zhang, Hui; Akef, Abdalla; Cui, Xianying A.; Gueroussov, Serge; Cenik, Can; Roth, Frederick; Palazzo, Alexander F. (Public Library of Science, 2013)
      In higher eukaryotes, most mRNAs that encode secreted or membrane-bound proteins contain elements that promote an alternative mRNA nuclear export (ALREX) pathway. Here we report that ALREX-promoting elements also potentiate ...
    • Studies on the Evolution and Function of Introns in 5' Untranslated Regions 

      Cenik, Can (2013-02-06)
      The function and evolution of introns have been topics of great interest since introns were discovered in the 1970s. Introns that interrupt protein-coding regions have the most obvious potential to affect coding sequences; ...
    • Systematic Exploration of Synergistic Drug Pairs 

      Cokol, Murat; Tasan, Murat; Weinstein, Zohar B; Suzuki, Yo; Nergiz, Mehmet E; Costanzo, Michael; Baryshnikova, Anastasia; Giaever, Guri; Nislow, Corey; Myers, Chad L; Andrews, Brenda J; Boone, Charles; Chua, Hon Nian; Mutlu, Beste; Roth, Frederick Phillip (Nature Publishing Group, 2011)
      Drug synergy allows a therapeutic effect to be achieved with lower doses of component drugs. Drug synergy can result when drugs target the products of genes that act in parallel pathways (‘specific synergy’). Such cases of ...
    • Viral Perturbations of Host Networks Reflect Disease Etiology 

      Gulbahce, Natali; Yan, Han; Dricot, Amélie; Padi, Megha; Byrdsong, Danielle; Franchi, Rachel; Lee, Deok-Sun; Rozenblatt-Rosen, Orit; Mar, Jessica C.; Calderwood, Michael A; Baldwin, Amy; Zhao, Bo; Santhanam, Balaji; Braun, Pascal; Simonis, Nicolas; Huh, Kyung-Won; Hellner, Karin; Grace, Miranda; Chen, Alyce Aura; Rubio, Renee; Marto, Jarrod; Christakis, Nicholas Alexander; Kieff, Elliott D.; Roth, Frederick Phillip; Roecklein-Canfield, Jennifer; DeCaprio, James A.; Cusick, Michael; Quackenbush, John; Hill, David E.; Münger, Karl; Vidal, Marc; Barabási, Albert-László (Public Library of Science, 2012)
      Many human diseases, arising from mutations of disease susceptibility genes (genetic diseases), are also associated with viral infections (virally implicated diseases), either in a directly causal manner or by indirect ...