Now showing items 1-18 of 18

    • Blunted Response to Combination Antiretroviral Therapy in HIV Elite Controllers: An International HIV Controller Collaboration 

      Boufassa, Faroudy; Lechenadec, Jérome; Meyer, Laurence; Costagliola, Dominique; Hunt, Peter W.; Pereyra, Florencia; Deeks, Steve; Pancino, Gianfranco; Taulera, Olivier; Lichterfeld, Mathias; Delobel, Pierre; Saez-Cirion, Asier; Lambotte, Olivier (Public Library of Science, 2014)
      Objective: HIV “elite controllers” (ECs) spontaneously control viral load, but some eventually require combination antiretroviral treatment (cART), due to a loss of viral control or a decline in CD4 T-cell counts. Here we ...
    • Broad activation of latent HIV-1 in vivo 

      Barton, Kirston; Hiener, Bonnie; Winckelmann, Anni; Rasmussen, Thomas Aagaard; Shao, Wei; Byth, Karen; Lanfear, Robert; Solomon, Ajantha; McMahon, James; Harrington, Sean; Buzon, Maria; Lichterfeld, Mathias; Denton, Paul W.; Olesen, Rikke; Østergaard, Lars; Tolstrup, Martin; Lewin, Sharon R.; Søgaard, Ole Schmeltz; Palmer, Sarah (Nature Publishing Group, 2016)
      The ‘shock and kill' approach to cure human immunodeficiency virus (HIV) includes transcriptional induction of latent HIV-1 proviruses using latency-reversing agents (LRAs) with targeted immunotherapy to purge infected ...
    • Functional Characterization of HLA-G+ Regulatory T Cells in HIV-1 Infection 

      Li, Chun; Toth, Ilona; Schulze zur Wiesch, Julian; Pereyra, Florencia; Rychert, Jennifer Ann; Rosenberg, Eric Scott; van Lunzen, Jan; Lichterfeld, Mathias; Yu, Xu (Public Library of Science, 2013)
      Regulatory T cells represent a specialized subpopulation of T lymphocytes that may modulate spontaneous HIV-1 disease progression by suppressing immune activation or inhibiting antiviral T cell immune responses. While the ...
    • Histone Deacetylase Inhibitors Impair the Elimination of HIV-Infected Cells by Cytotoxic T-Lymphocytes 

      Jones, Richard Brad; O'Connor, Rachel; Mueller, Stefanie; Foley, Maria; Szeto, Gregory L.; Karel, Dan; Lichterfeld, Mathias; Kovacs, Colin; Ostrowski, Mario A.; Trocha, Alicja; Irvine, Darrell J.; Walker, Bruce D. (Public Library of Science, 2014)
      Resting memory CD4+ T-cells harboring latent HIV proviruses represent a critical barrier to viral eradication. Histone deacetylase inhibitors (HDACis), such as suberanilohydroxamic acid (SAHA), romidepsin, and panobinostat ...
    • HIV-1 persistence in CD4+ T cells with stem cell-like properties 

      Buzon, Maria J.; Sun, Hong; Li, Chun; Shaw, Amy; Seiss, Katherine; Ouyang, Zhengyu; Martin-Gayo, Enrique; Leng, Jin; Henrich, Timothy J.; Li, Jonathan Z.; Pereyra, Florencia; Zurakowski, Ryan; Walker, Bruce D.; Rosenberg, Eric S.; Yu, Xu G.; Lichterfeld, Mathias (2014)
      Cellular HIV-1 reservoirs that persist despite antiretroviral treatment are incompletely defined. We show that during suppressive antiretroviral therapy, CD4+ T memory stem cells (TSCM) harbor high per-cell levels of HIV-1 ...
    • HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1 

      Kalife, Elizabeth T; Qi, Ying; Johnston, Mary N; Burgett, Nicole; Swartz, Martha E; Yang, Amy; Rockstroh, Juergen K; Jessen, Heiko; Carrington, Mary; Altfeld, Marcus; Streeck, Hendrik; Lichterfeld, Mathias; Alter, Galit; Yu, Xu; Meier, Angela; Allen, Todd; Rosenberg, Eric Scott; Walker, Bruce David (Public Library of Science, 2006)
      Background: Very little is known about the immunodominance patterns of HIV-1-specific T cell responses during primary HIV-1 infection and the reasons for human lymphocyte antigen (HLA) modulation of disease progression. ...
    • HLA-B*35-Px–mediated Acceleration of HIV-1 Infection by Increased Inhibitory Immunoregulatory Impulses 

      Goedert, James J.; Sundberg, Eric J.; Cung, Thai Duong Hong; Burke, Patrick S.; Preiss, Liliana; Lifson, Jeffrey; Carrington, Mary; Huang, Jinghe; Martin, Maureen P.; Lichterfeld, Mathias; Yu, Xu (The Rockefeller University Press, 2009)
      A subset of HLA-B*35 alleles, B*35-Px, are strongly associated with accelerated HIV-1 disease progression for reasons that are not understood. Interestingly, the alternative set of B*35 subtypes, B*35-PY, have no detectable ...
    • Identification of CD8+ T Cell Host Factors Involved in HIV Control 

      Gaiha, Gaurav Das; McKim, K; Woods, M; Lichterfeld, Mathias; Brass, A; Wallker, B (BioMed Central, 2012)
    • Integrated and Total HIV-1 DNA Predict Ex Vivo Viral Outgrowth 

      Kiselinova, Maja; De Spiegelaere, Ward; Buzon, Maria Jose; Malatinkova, Eva; Lichterfeld, Mathias; Vandekerckhove, Linos (Public Library of Science, 2016)
      The persistence of a reservoir of latently infected CD4 T cells remains one of the major obstacles to cure HIV. Numerous strategies are being explored to eliminate this reservoir. To translate these efforts into clinical ...
    • Interactions between HLA-B and Leukocyte Immunoglobulin like Receptors B2 (LILRB2) Correlate with HIV-1 Disease Outcomes 

      Martin Gayo, Enrique; Jones, D.; Pereyra, Florencia M.; Lichterfeld, Mathias; Allen, R. L.; Yu, X. G. (BioMed Central, 2012)
    • LILRB2 Interaction with HLA Class I Correlates with Control of HIV-1 Infection 

      Bashirova, Arman A.; Martin-Gayo, Enrique; Jones, Des C.; Qi, Ying; Apps, Richard; Gao, Xiaojiang; Burke, Patrick S.; Taylor, Craig J.; Rogich, Jerome; Wolinsky, Steven; Bream, Jay H.; Duggal, Priya; Hussain, Shehnaz; Martinson, Jeremy; Weintrob, Amy; Kirk, Gregory D.; Fellay, Jacques; Buchbinder, Susan P.; Goedert, James J.; Deeks, Steven G.; Pereyra, Florencia; Trowsdale, John; Lichterfeld, Mathias; Telenti, Amalio; Walker, Bruce D.; Allen, Rachel L.; Carrington, Mary; Yu, Xu G. (Public Library of Science, 2014)
      Natural progression of HIV-1 infection depends on genetic variation in the human major histocompatibility complex (MHC) class I locus, and the CD8+ T cell response is thought to be a primary mechanism of this effect. ...
    • Mutational Escape in HIV-1 CTL Epitopes Leads to Increased Binding to Inhibitory Myelomonocytic MHC Class I Receptors 

      Yang, Yue; Huang, Jinghe; Toth, Ildiko; Lichterfeld, Mathias; Yu, Xu (Public Library of Science, 2010)
      Escape mutations in HIV-1 cytotoxic T cell (CTL) epitopes can abrogate recognition by the TCR of HIV-1-specific CD8+ T cells, but may also change interactions with alternative MHC class I receptors. Here, we show that ...
    • Potent Cell-Intrinsic Immune Responses in Dendritic Cells Facilitate HIV-1-Specific T Cell Immunity in HIV-1 Elite Controllers 

      Martin-Gayo, Enrique; Buzon, Maria Jose; Ouyang, Zhengyu; Hickman, Taylor; Cronin, Jacqueline; Pimenova, Dina; Walker, Bruce D.; Lichterfeld, Mathias; Yu, Xu G. (Public Library of Science, 2015)
      The majority of HIV-1 elite controllers (EC) restrict HIV-1 replication through highly functional HIV-1-specific T cell responses, but mechanisms supporting the evolution of effective HIV-1-specific T cell immunity in these ...
    • Reactivation of latent HIV-1 in central memory CD4+ T cells through TLR-1/2 stimulation 

      Novis, Camille L; Archin, Nancie M; Buzon, Maria J; Verdin, Eric; Round, June L; Lichterfeld, Mathias; Margolis, David M; Planelles, Vicente; Bosque, Alberto (BioMed Central, 2013)
      Background: Toll-like receptors (TLRs) are crucial for recognition of pathogen-associated molecular patterns by cells of the innate immune system. TLRs are present and functional in CD4+ T cells. Memory CD4+ T cells, ...
    • Second European Round Table on the Future Management of HIV: 10–11 October 2014, Barcelona, Spain 

      Rokx, Casper; Richman, Douglas D; Müller-Trutwin, Michaela; Silvestri, Guido; Lunzen, Jan; Khoo, Saye; Lichterfeld, Mathias; Altfeld, Marcus; Perno, Carlo Federico; Hunt, Peter W; Mallon, Paddy; Rockstroh, Jürgen K; Pozniak, Anton L; Clotet, Bonaventura; Boucher, Charles AB (Mediscript Ltd, 2015)
      Abstract The Second European Round Table on the Future Management of HIV took place in Barcelona, 10–11 October 2014 and focused on the HIV-1 reservoir, strategies for HIV cure and primary HIV infection (PHI). Important ...
    • A Subset of Latency-Reversing Agents Expose HIV-Infected Resting CD4+ T-Cells to Recognition by Cytotoxic T-Lymphocytes 

      Jones, R. Brad; Mueller, Stefanie; O’Connor, Rachel; Rimpel, Katherine; Sloan, Derek D.; Karel, Dan; Wong, Hing C.; Jeng, Emily K.; Thomas, Allison S.; Whitney, James B.; Lim, So-Yon; Kovacs, Colin; Benko, Erika; Karandish, Sara; Huang, Szu-Han; Buzon, Maria J.; Lichterfeld, Mathias; Irrinki, Alivelu; Murry, Jeffrey P.; Tsai, Angela; Yu, Helen; Geleziunas, Romas; Trocha, Alicja; Ostrowski, Mario A.; Irvine, Darrell J.; Walker, Bruce D. (Public Library of Science, 2016)
      Resting CD4+ T-cells harboring inducible HIV proviruses are a critical reservoir in antiretroviral therapy (ART)-treated subjects. These cells express little to no viral protein, and thus neither die by viral cytopathic ...
    • Systemic Inhibition of Myeloid Dendritic Cells by Circulating HLA Class I Molecules in HIV-1 Infection 

      Huang, Jinghe; Al-Mozaini, Maha Ahmed; Rogich, Jerome; Carrington, Mary F.; Seiss, Katherine; Pereyra, Florencia M.; Lichterfeld, Mathias; Yu, Xu (BioMed Central, 2012)
      Background: HIV-1 infection is associated with profound dysfunction of myeloid dendritic cells, for reasons that remain ill-defined. Soluble HLA class I molecules can have important inhibitory effects on T cells and NK ...
    • Transcriptional Changes in CD8+ T Cells During Antiretroviral Therapy Intensified With Raltegravir 

      Ouyang, Zhengyu; Buzon, Maria J.; Zheng, Lu; Sun, Hong; Yu, Xu G.; Bosch, Ronald J.; Mellors, John W.; Eron, Joseph J.; Gandhi, Rajesh T.; Lichterfeld, Mathias (Oxford University Press, 2015)
      Background. Intensification of antiretroviral therapy with raltegravir does not affect levels of residual human immunodeficiency virus (HIV)-1 viremia, but it has led to increased levels of episomal HIV-1 DNA in some ...