Browsing by Author "Greenberg, Steven"

Now showing items 1-6 of 6

    • Combining Gene Expression Data from Different Generations of Oligonucleotide Arrays 

      Hwang, Kyu-Baek; Kong, Sek Won; Greenberg, Steven A.; Park, Peter J. (BioMed Central, 2004)
      Background: One of the important challenges in microarray analysis is to take full advantage of previously accumulated data, both from one's own laboratory and from public repositories. Through a comparative analysis on a ...

    • Fludarabine add-on therapy in interferon-beta-treated patients with multiple sclerosis experiencing breakthrough disease 

      Greenberg, Steven A.; Zivadinov, R.; Lee-Kwen, P.; Sharma, Jitendra; Planter, M.; Umhauer, M.; Glenister, N.; Bakshi, Rohit (SAGE Publications, 2016)
      Background: Patients with relapsing–remitting multiple sclerosis (RRMS) may experience breakthrough disease despite effective interferon beta (IFNβ) therapy. Fludarabine (FLU) is a chemotherapeutic agent used in ...

    • Genomic Signatures Characterize Leukocyte Infiltration in Myositis Muscles 

      Zhu, Wei; Streicher, Katie; Shen, Nan; Higgs, Brandon W; Morehouse, Chris; Greenlees, Lydia; Amato, Anthony A.; Ranade, Koustubh; Richman, Laura; Fiorentino, David; Jallal, Bahija; Greenberg, Steven A.; Yao, Yihong (BioMed Central, 2012)
      Background: Leukocyte infiltration plays an important role in the pathogenesis and progression of myositis, and is highly associated with disease severity. Currently, there is a lack of: efficacious therapies for myositis; ...

    • A phase 1b clinical trial evaluating sifalimumab, an anti-IFN-α monoclonal antibody, shows target neutralisation of a type I IFN signature in blood of dermatomyositis and polymyositis patients 

      Higgs, Brandon W; Zhu, Wei; Morehouse, Chris; White, Wendy I; Brohawn, Philip; Guo, Xiang; Rebelatto, Marlon; Le, Chenxiong; Amato, Anthony; Fiorentino, David; Greenberg, Steven A; Drappa, Jorn; Richman, Laura; Greth, Warren; Jallal, Bahija; Yao, Yihong (BMJ Publishing Group, 2014)
      Objective: To assess the pharmacodynamic effects of sifalimumab, an investigational anti-IFN-α monoclonal antibody, in the blood and muscle of adult dermatomyositis and polymyositis patients by measuring neutralisation of ...

    • Prion-like domain mutations in hnRNPs cause multisystem proteinopathy and ALS 

      Kim, Hong Joo; Kim, Nam Chul; Wang, Yong-Dong; Scarborough, Emily A.; Moore, Jennifer; Diaz, Zamia; MacLea, Kyle S.; Freibaum, Brian; Li, Songqing; Molliex, Amandine; Kanagaraj, Anderson P.; Carter, Robert; Boylan, Kevin B.; Wojtas, Aleksandra M.; Rademakers, Rosa; Pinkus, Jack L.; Greenberg, Steven A.; Trojanowski, John Q.; Traynor, Bryan J.; Smith, Bradley N.; Topp, Simon; Gkazi, Athina-Soragia; Miller, Jack; Shaw, Christopher E.; Kottlors, Michael; Kirschner, Janbernd; Pestronk, Alan; Li, Yun R.; Ford, Alice Flynn; Gitler, Aaron D.; Benatar, Michael; King, Oliver D.; Kimonis, Virginia E.; Ross, Eric D.; Weihl, Conrad C.; Shorter, James; Taylor, J. Paul (2013)
      Summary Algorithms designed to identify canonical yeast prions predict that ~250 human proteins, including several RNA-binding proteins associated with neurodegenerative disease, harbor a distinctive prion-like domain ...

    • Type 1 Interferons Inhibit Myotube Formation Independently of Upregulation of Interferon-Stimulated Gene 15 

      Franzi, Sara; Salajegheh, Mohammad; Nazareno, Remedios; Greenberg, Steven A. (Public Library of Science, 2013)
      Introduction: Type 1 interferon (IFN)-inducible genes and their inducible products are upregulated in dermatomyositis muscle. Of these, IFN-stimulated gene 15 (ISG15) is one of the most upregulated, suggesting its possible ...